Obstetrics‐based clinical immersion of a multinational team of biomedical engineering students in Ghana

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135577/1/ijgo218.pd

Effectiveness of interventions to support the early detection of skin cancer through skin self-examination: a systematic review and meta-analysis.

BACKGROUND: As skin cancer incidence rises, there is a need to evaluate early detection interventions by the public using skin self-examination (SSE); however, the literature focuses on primary prevention. No systematic reviews have evaluated the effectiveness of such SSE interventions. OBJECTIVES: To systematically examine, map, appraise and synthesize, qualitatively and quantitatively, studies evaluating the early detection of skin cancer, using SSE interventions. METHODS: This is a systematic review (narrative synthesis and meta-analysis) examining randomized controlled trials (RCTs) and quasiexperimental, observational and qualitative studies, published in English, using PRISMA and National Institute for Health and Care Excellence guidance. The MEDLINE, Embase and PsycINFO databases were searched through to April 2015 (updated in April 2018 using MEDLINE). Risk-of-bias assessment was conducted. RESULTS: Included studies (n = 18), totalling 6836 participants, were derived from 22 papers; these included 12 RCTs and five quasiexperiments and one complex-intervention development. More studies (n = 10) focused on targeting high-risk groups (surveillance) than those at no higher risk (screening) (n = 8). Ten (45%) study interventions were theoretically underpinned. All of the study outcomes were self-reported, behaviour related and nonclinical in nature. Meta-analysis demonstrated the impact of the intervention on the degree of SSE activity from five studies, especially in the short term (up to 4 months) (odds ratio 2·31, 95% confidence interval 1·90-2·82), but with small effect sizes. Risk-of-bias assessment indicated that 61% of the studies (n = 11) were of weak quality. CONCLUSIONS: Four RCTs and a quasiexperimental study indicate that some interventions can enhance SSE activity and so are more likely to aid early detection of skin cancer. However, the actual clinical impact remains unclear, and this is based on overall weak study (evidence) quality

Dynamic Changes in the Endocannabinoid System during the Aging Process: Focus on the Middle-Age Crisis

Endocannabinoid (eCB) signaling is markedly decreased in the hippocampus (Hip) of aged mice, and the genetic deletion of the cannabinoid receptor type 1 (CB1) leads to an early onset of cognitive decline and age-related histological changes in the brain. Thus, it is hypothesized that cognitive aging is modulated by eCB signaling through CB1. In the present study, we detailed the changes in the eCB system during the aging process using different complementary techniques in mouse brains of five different age groups, ranging from adolescence to old age. Our findings indicate that the eCB system is most strongly affected in middle-aged mice (between 9 and 12 months of age) in a brain region-specific manner. We show that 2-arachidonoylglycerol (2-AG) was prominently decreased in the Hip and moderately in caudate putamen (CPu), whereas anandamide (AEA) was decreased in both CPu and medial prefrontal cortex along with cingulate cortex (mPFC+Cg), starting from 6 months until 12 months. Consistent with the changes in 2-AG, the 2-AG synthesizing enzyme diacylglycerol lipase α (DAGLα) was also prominently decreased across the sub-regions of the Hip. Interestingly, we found a transient increase in CB1 immunoreactivity across the sub-regions of the Hip at 9 months, a plausible compensation for reduced 2-AG, which ultimately decreased strongly at 12 months. Furthermore, quantitative autoradiography of CB1 revealed that [3H]CP55940 binding markedly increased in the Hip at 9 months. However, unlike the protein levels, CB1 binding density did not drop strongly at 12 months and at old age. Furthermore, [3H]CP55940 binding was significantly increased in the lateral entorhinal cortex (LEnt), starting from the middle age until the old age. Altogether, our findings clearly indicate a middle-age crisis in the eCB system, which could be a potential time window for therapeutic interventions to abrogate the course of cognitive aging

Red-Black Balanced Trie Hashing

Trie hashing is a scheme, proposed by Litwin, for indexing records with very long alphanumeric keys. The records are grouped into buckets of capacity b records per bucket and maintained on secondary storage. To retrieve a record, the memory resident trie is traversed from the root to a leaf node where the address of the target bucket is found. Using the address found, the data bucket is read into memory and searched to determine the presence or absence of the record. The scheme, for all practical purposes, locates a record in one or two disk accesses. Unlike a trie, the scheme suffers from: i) potential degeneracy when the keys inserted are ordered, ii) expensive reconstruction cost if a system failure occurs during a session. We present a new approach to implementing Trie Hashing that resolves the problem of potential degeneracy. Our approach combines the basic trie hashing algorithm with the balancing techniques of the Red-Black Binary Search Tree, to produce a relatively balanced tr..

Exploring decision-making performance in young adults with mental health disorders: a comparative study using the Cambridge Gambling Task

Background: decision-making deficits, assessed cognitively, are often associated with mental health symptoms, however, this relationship is not fully understood. This paper explores the relationship between mental health disorders and decision-making, using the Cambridge Gambling Task (CGT).Methods: our study investigated how decision-making varied across 20 different mental health conditions compared to controls in a sample of 572 young adults from the Minneapolis and Chicago metropolitan areas, using a computerised laboratory-based task.Results: almost all mental health conditions were associated with at least mild (i.e., at least small effect size) impairment in all three studied parameters of the CGT (risk adjustment, quality of decision-making and overall proportion of bet). Notably, binge eating disorder had the largest cognitive impairment and gambling disorder had moderate impairment. Post-traumatic stress disorder (PTSD) was associated with impaired decision-making while obsessive-compulsive disorder (OCD) and depression showed moderate impairment. Additionally, half of the disorders assessed had moderate to large impairment in risk adjustment.Conclusion: these findings suggest that mental health conditions may have a more complex cognitive profile than previously thought, and a better understanding of these impairments may aid in risk assessment and targeted clinical interventions. This study underscores the need for further research to determine the causal pathways between mental health conditions and cognition, as well as to better understand the day-to-day impact of such deficits.<br/

Effects of Two Invasive Weeds on Arthropod Community Structure on the Central Plateau of New Zealand

Publishe

Seasonal and environmental variation in volatile emissions of the New Zealand native plant Leptospermum scoparium in weed-invaded and non-invaded sites

Publishe

Evaluating the effectiveness of strategies for extirpating corrupt practices in infrastructure project procurement

This study examined the efficacy of anticorruption measures for extirpating the prevalence of corrupt practices in infrastructure procurement in developing countries. The study employed the fuzzy synthetic evaluation (FSE) technique to assess 62 responses from practitioners involved in the procurement and delivery of infrastructure projects. The probing measures were identified to be the highest-ranked construct, followed by the managerial measures. The remaining constructs with their variables were revealed to be moderately effective. The study has revealed the level of effectiveness of existing anticorruption measures that are widely applied to check, thwart, and extirpate corrupt practices in the procurement and delivery of infrastructure projects. This study theoretically contributes to the body of knowledge on corruption in infrastructure procurement by evaluating the effectiveness of anticorruption measures. Practically, this study provides useful information for project parties, policy makers, anticorruption institutions, and researchers toward the reinforcement of the existing measures for the expurgation of corrupt practices in infrastructure projects’ procurement, delivery, and management