On the importance of initial conditions for simulations of the Mid-Holocene climate.

Three simulations of the Mid-Holocene (6 ka) climate were performed with the ECBilt-CLIO-VECODE coupled atmosphere-ocean-vegetation model to study the impact of initial conditions. These experiments were forced with identical 6 ka forcings (orbital parameters and atmospheric greenhouse gas concentrations) and differed only in initial conditions. Two simulations were designed as equilibrium experiments, with one being initialized with preindustrial conditions as required by the protocol of the Paleoclimate Modelling Intercomparison Project (PMIP), while in a second experiment early Holocene (9 ka) initial conditions were used. These equilibrium simulations were run for 2100 years with 6 ka forcings. The third experiment was set up as a transient simulation, also starting from early Holocene conditions, but forced with annually changing orbital parameters and greenhouse gas levels. The results of the last 100 years are compared and reveal no statistically significant differences, showing that in this model the initial conditions have no discernible impact on the 6 ka climate. This suggests that the PMIP set-up for 6 ka simulations is valid, with the condition that spin-up phase should be long enough (at least 550 years) to allow the deep ocean to adjust to the change in forcings

Modelling the climate of the last millennium: what causes the differences between simulations?

An ensemble of simulations performed with a coarse resolution 3-D climate model driven by various combinations of external forcing is used to investigate possible causes for differences noticed in two recent simulations of the climate of the past millennium using General Circulation Models (GCMs). Our results strongly suggest that differences in sensitivity (equilibrium and transient climate response) could be responsible for temperature changes that differ by more than a factor of two between two models. In addition, the spin-up procedure could explain some differences between the simulations during the first centuries of the second millennium. The choice of the forcing reconstruction is found to play a smaller role for the differences in the simulated climate, in the model configurations analyzed here. Furthermore, at decadal scale, internal climate variability can mask the differences associated with different forcing reconstructrions. Copyright 2005 by the American Geophysical Union

The Eurasian ice sheet reinforces the East Asian summer monsoon during the interglacial 500 000 years ago

Deep-sea and ice-core records show that interglacial periods were overall less "warm" before about 420 000 years ago than after, with relatively higher ice volume and lower greenhouse gases concentration. This is particularly the case for the interglacial Marine Isotope Stage 13 which occurred about 500 000 years ago. However, by contrast, the loess and other proxy records from China suggest an exceptionally active East Asian summer monsoon during this interglacial. A three-dimension Earth system Model of Intermediate complexity was used to understand this seeming paradox. The astronomical forcing and the remnant ice sheets present in Eurasia and North America were taken into account in a series of sensitivity experiments. Expectedly, the seasonal contrast is larger and the East Asian summer monsoon is reinforced compared to Pre-Industrial time when Northern Hemisphere summer is at perihelion. Surprisingly, the presence of the Eurasian ice sheet was found to reinforce monsoon, too, through a south-eastwards perturbation planetary wave. The trajectory of this wave is influenced by the Tibetan plateau

Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression

Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters such as oxygen (pO2), extracellular acidosis (pHe), and concentration of interstitial inorganic phosphate (Pi) may provide unique insights into biological processes in solid tumors. In this work, we employ a recently developed multifunctional trityl paramagnetic probe and electron paramagnetic resonance (EPR) technique for in vivo concurrent assessment of these TME parameters in various mouse models of cancer. While the data support the existence of hypoxic and acidic regions in TME, the most dramatic differences, about 2-fold higher concentrations in tumors vs. normal tissues, were observed for interstitial Pi - the only parameter that also allowed for discrimination between non-metastatic and highly metastatic tumors. Correlation analysis between [Pi], pO2, pHe and tumor volumes reveal an association of high [Pi] with changes in tumor metabolism and supports different mechanisms of protons and Pi accumulation in TME. Our data identifies interstitial inorganic phosphate as a new TME marker for tumor progression. Pi association with tumor metabolism, buffer-mediated proton transport, and a requirement of high phosphorus content for the rapid growth in the “growth rate hypothesis” may underline its potential role in tumorigenesis and tumor progression

Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression

Noninvasive in vivo assessment of chemical tumor microenvironment (TME) parameters such as oxygen (pO2), extracellular acidosis (pHe), and concentration of interstitial inorganic phosphate (Pi) may provide unique insights into biological processes in solid tumors. In this work, we employ a recently developed multifunctional trityl paramagnetic probe and electron paramagnetic resonance (EPR) technique for in vivoconcurrent assessment of these TME parameters in various mouse models of cancer. While the data support the existence of hypoxic and acidic regions in TME, the most dramatic differences, about 2-fold higher concentrations in tumors vs. normal tissues, were observed for interstitial Pi - the only parameter that also allowed for discrimination between non-metastatic and highly metastatic tumors. Correlation analysis between [Pi], pO2, pHe and tumor volumes reveal an association of high [Pi] with changes in tumor metabolism and supports different mechanisms of protons and Pi accumulation in TME. Our data identifies interstitial inorganic phosphate as a new TME marker for tumor progression. Pi association with tumor metabolism, buffer-mediated proton transport, and a requirement of high phosphorus content for the rapid growth in the “growth rate hypothesis” may underline its potential role in tumorigenesis and tumor progression

Modeling the influence of Greenland ice sheet melting on the Atlantic meridional overturning circulation during the next millennia

A three-dimensional Earth system model of intermediate complexity including a dynamic ice sheet component has been used to investigate the long-term evolution of the Greenland ice sheet and its effects on the Atlantic meridional overturning circulation (AMOC) in response to a range of stabilized anthropogenic forcings. Our results suggest that the Greenland ice sheet volume should experience a significant decrease in the future. For a radiative forcing exceeding 7.5 W m-2, the modeled ice sheet melts away within 3000 years. A number of feedbacks operate during this deglaciation, implying a strong nonlinear relationship between the radiative forcing and the melting rate. Only in the most extreme scenarios considered, the freshwater flux from Greenland into the surrounding oceans (of ca. 0.1 Sv during a few centuries) induces a noticeable weakening of the AMOC in the model

Information on the early Holocene climate constrains the summer sea ice projections for the 21st century

International audienceThe summer sea ice extent strongly decreased in the Arctic over the last decades. This decline is very likely to continue in the future but uncertainty on projections is very large. An ensemble of experiments with the climate model LOVECLIM using 5 different parameter sets has been performed to show that summer sea ice changes for the early Holocene and for the 21st century are strongly linked, allowing to reduce this uncertainty. Using the limited information presently available for the early Holocene, simulations presenting very large changes for the 21st century could reasonably be rejected. On the other hand, simulations displaying low to moderate changes during the second half of the 20th century are not consistent with recent observations. Using this evidence based on observations during both the early Holocene and the last decades, the most realistic projection indicates a nearly disappearance of the sea ice at the end of the 21st century for a moderate increase in atmospheric greenhouse gas concentrations. For a faster increase in those concentrations, the Arctic Ocean would become almost ice-free in summer as early as 2060 AD

The effect of dynamic-thermodynamic icebergs on the Southern Ocean climate in a three-dimentional model

Melting icebergs are a mobile source of fresh water as well as a sink of latent heat. In most global climate models, the spatio-temporal redistribution of fresh water and latent heat fluxes related to icebergs is parameterized by an instantaneous more or less arbitrary flux distribution over some parts of the oceans. It is uncertain if such a parameterization provides a realistic representation of the role of icebergs in the coupled climate system. However, icebergs could have a significant climate role, in particular during past abrupt climate change events which have been associated with armada’s of icebergs. We therefore present the interactive coupling of a global climate model to a dynamic thermodynamic iceberg model, leading to a more plausible spatio-temporal redistribution of fresh water and heat fluxes. We show first that our model is able to reproduce a reasonable iceberg distribution in both hemispheres when compared to recent data. Second, in a series of sensitivity experiments we explore cooling and freshening effects of dynamical icebergs on the upper Southern Ocean and we compare these dynamic iceberg results to the effects of an equivalent parameterized iceberg flux. In our model without interactive icebergs, the parameterized fluxes are distributed homogeneously South of 55°S, whereas dynamic icebergs are found to be concentrated closer to shore except for a plume of icebergs floating North–East from the tip of the Antarctic Peninsula. Compared to homogeneous fluxes, the dynamic icebergs lead to a 10% greater net production of Antarctic bottom water (AABW). This increased bottom water production involves open ocean convection, which is enhanced by a less efficient stratification of the ocean when comparing to a homogeneous flux distribution. Icebergs facilitate the formation of sea-ice. In the sensitivity experiments, both the fresh water and the cooling flux lead to a significant increase in sea-ice area of 12% and 6%, respectively, directly affecting the highly coupled and interactive air/sea/ice system. The consequences are most pronounced along the sea-ice edge, where this sea-ice facilitation has the greatest potential to affect ocean stratification, for example by heat insulation and wind shielding, which further amplifies the cooling and freshening of the surface waters