Evaluation of the Freshman Seminar Program at Eastern Illinois University and Its Perceived Impact on First-Year Student Development

This study examined the development of first-year college students at Eastern Illinois University in order to determine if student development was strengthened with the assistance of an eight-week Freshman Seminar course. Additionally, this study evaluated the fall semester, 1999 Freshman Seminar course in order to determine students\u27 perceptions of the course and its content both at the start and completion of the course. The research population consisted of first-year students who were enrolled in Freshman Seminar (N = 303) and first-year students who were enrolled in an Introductory Speech Communications (SPC 1310) course, but not enrolled in Freshman Seminar (N = 215). This study incorporated both quantitative and qualitative methodologies. The locally-developed, quantitative First-Year Student Development Survey (FYSDS) and qualitative Freshman Seminar Survey (FSS), along with the confirmation of a Freshman Focus Group, supported the following results: 1) Based on scores from the FYSDS, student development took place among first-year students during the first eight weeks of college regardless of their enrollment in Freshman Seminar. 2) There was no significant difference in the initial perceived level of student development between Freshman Seminar students and Non-Freshman Seminar students on the FYSDS. 3) At the end of the first eight weeks of college, there was a higher level of student development reported by first-year students who took Freshman Seminar on the FYSDS than first-year students who did not take Freshman Seminar. 4) Students who took Freshman Seminar reported the course to have positively assisted them in their initial transition to college. 5) First-year students who took Freshman Seminar recommended that other incoming first-year students take the course in subsequent years

Wee Women\u27s Work : Women and Peacebuilding in Northern Ireland

International norms on intrastate conflicts, such as United Nations Security Council Resolution 1325, call for women to participate in peace processes in countries emerging from conflict and civil strife, including those divided by identity-based conflict. However, scholars of post-war recovery in international relations and comparative politics have raised questions about the extent and effect of women’s participation in peace processes, and in politics more generally, in divided societies given underlying social, economic, and political barriers that impeded access to decisive or authoritative political decision-making. A critical question in the literature on women’s participation in post-conflict reconciliation-related dialogue and joint action relates to whether intragroup “community development” focusing principally on social and economic concerns can contribute to fostering women’s participation in intergroup reconciliation and peacebuilding. This study explores the experiences of community development in Northern Ireland with the research question: How and under what conditions do women contribute to peacebuilding? The research represents formal interviews with experts in the community and voluntary sector and the women’s sector, informal focus groups, and six months of ethnographic field research based primarily in Belfast. Northern Ireland is a case of protracted social conflict in which the society is still deeply divided, despite successful implementation of the Good Friday Agreement. Women played a significant role in the peace process by forming their own political party—the Northern Ireland Women’s Coalition—and yet are poorly represented in political institutions today. Instead, women dominate the field of community development contributing to peace through capacity-building and other bottom-up practices. Women pursue community development in this case for two broad reasons: first, because it is not political in the formal institutional sense; second, in an environment where women are expected to play traditional roles, community development is interpreted as an extension of these roles allowing women to navigate through the constraints of a gendered public space and employ their roles as women to seek change that does not threaten the political status quo

Evaluation of the Freshman Seminar Program at Eastern Illinois University and Its Perceived Impact on First-Year Student Development

This study examined the development of first-year college students at Eastern Illinois University in order to determine if student development was strengthened with the assistance of an eight-week Freshman Seminar course. Additionally, this study evaluated the fall semester, 1999 Freshman Seminar course in order to determine students\u27 perceptions of the course and its content both at the start and completion of the course. The research population consisted of first-year students who were enrolled in Freshman Seminar (N = 303) and first-year students who were enrolled in an Introductory Speech Communications (SPC 1310) course, but not enrolled in Freshman Seminar (N = 215). This study incorporated both quantitative and qualitative methodologies. The locally-developed, quantitative First-Year Student Development Survey (FYSDS) and qualitative Freshman Seminar Survey (FSS), along with the confirmation of a Freshman Focus Group, supported the following results: 1) Based on scores from the FYSDS, student development took place among first-year students during the first eight weeks of college regardless of their enrollment in Freshman Seminar. 2) There was no significant difference in the initial perceived level of student development between Freshman Seminar students and Non-Freshman Seminar students on the FYSDS. 3) At the end of the first eight weeks of college, there was a higher level of student development reported by first-year students who took Freshman Seminar on the FYSDS than first-year students who did not take Freshman Seminar. 4) Students who took Freshman Seminar reported the course to have positively assisted them in their initial transition to college. 5) First-year students who took Freshman Seminar recommended that other incoming first-year students take the course in subsequent years

AMH/MIS as a contraceptive that protects the ovarian reserve during chemotherapy

The ovarian reserve represents the stock of quiescent primordial follicles in the ovary which is gradually depleted during a woman\u27s reproductive lifespan, resulting in menopause. Mullerian inhibiting substance (MIS) (or anti-Mullerian hormone/AMH), which is produced by granulosa cells of growing follicles, has been proposed as a negative regulator of primordial follicle activation. Here we show that long-term parenteral administration of superphysiological doses of MIS, using either an adeno-associated virus serotype 9 (AAV9) gene therapy vector or recombinant protein, resulted in a complete arrest of folliculogenesis in mice. The ovaries of MIS-treated mice were smaller than those in controls and did not contain growing follicles but retained a normal ovarian reserve. When mice treated with AAV9/MIS were paired with male breeders, they exhibited complete and permanent contraception for their entire reproductive lifespan, disrupted vaginal cycling, and hypergonadotropic hypogonadism. However, when ovaries from AAV9-MIS-treated mice were transplanted orthotopically into normal recipient mice, or when treatment with the protein was discontinued, folliculogenesis resumed, suggesting reversibility. One of the important causes of primary ovarian insufficiency is chemotherapy-induced primordial follicle depletion, which has been proposed to be mediated in part by increased activation. To test the hypothesis that MIS could prevent chemotherapy-induced overactivation, mice were given carboplatin, doxorubicin, or cyclophosphamide and were cotreated with AAV9-MIS, recombinant MIS protein, or vehicle controls. We found significantly more primordial follicles in MIS-treated animals than in controls. Thus treatment with MIS may provide a method of contraception with the unique characteristic of blocking primordial follicle activation that could be exploited to prevent the primary ovarian insufficiency often associated with chemotherapy

Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer

© 2016 The Author(s)Anti-Müllerian hormone (AMH) and its type II receptor AMHR2, both previously thought to primarily function in gonadal tissue, were unexpectedly identified as potent regulators of transforming growth factor (TGF-β)/bone morphogenetic protein (BMP) signaling and epithelial-mesenchymal transition (EMT) in lung cancer. AMH is a TGF-β/BMP superfamily member, and AMHR2 heterodimerizes with type I receptors (ALK2, ALK3) also used by the type II receptor for BMP (BMPR2). AMH signaling regulates expression of BMPR2, ALK2, and ALK3, supports protein kinase B-nuclear factor κB (AKT-NF-κB) and SMAD survival signaling, and influences BMP-dependent signaling in non-small cell lung cancer (NSCLC). AMH and AMHR2 are selectively expressed in epithelial versus mesenchymal cells, and loss of AMH/AMHR2 induces EMT. Independent induction of EMT reduces expression of AMH and AMHR2. Importantly, EMT associated with depletion of AMH or AMHR2 results in chemoresistance but sensitizes cells to the heat shock protein 90 (HSP90) inhibitor ganetespib. Recognition of this AMH/AMHR2 axis helps to further elucidate TGF-β/BMP resistance-associated signaling and suggests new strategies for therapeutic targeting of EMT

Seroprevalence of Toxoplasma gondii infection in arthritis patients in eastern China

Background: There is accumulating evidence for an increased susceptibility to infection in patients with arthritis. We sought to understand the epidemiology of Toxoplasma gondii infection in arthritis patients in eastern China, given the paucity of data on the magnitude of T. gondii infection in these patients. Methods: Seroprevalence of T. gondii infection was assessed by enzyme-linked immunosorbent assay using a crude antigen of the parasite in 820 arthritic patients, and an equal number of healthy controls, from Qingdao and Weihai cities, eastern China. Sociodemographic, clinical and lifestyle information on the study participants were also obtained. Results: The prevalence of anti-T. gondii IgG was significantly higher in arthritic patients (18.8%) compared with 12% in healthy controls (P < 0.001). Twelve patients with arthritis had anti-T. gondii IgM antibodies comparable with 10 control patients (1.5% vs 1.2%). Demographic factors did not significantly influence these seroprevalence frequencies. The highest T. gondii infection seropositivity rate was detected in patients with rheumatoid arthritis (24.8%), followed by reactive arthritis (23.8%), osteoarthritis (19%), infectious arthritis (18.4%) and gouty arthritis (14.8%). Seroprevalence rates of rheumatoid arthritis and reactive arthritis were significantly higher when compared with controls (P < 0.001 and P = 0.002, respectively). A significant association was detected between T. gondii infection and cats being present in the home in arthritic patients (odds ratio [OR], 1.68; 95% confidence interval [CI]: 1.24 – 2.28; P = 0.001). Conclusions: These findings are consistent with and extend previous results, providing further evidence to support a link between contact with cats and an increased risk of T. gondii infection. Our study is also the first to confirm an association between T. gondii infection and arthritis patients in China. Implications for better prevention and control of T. gondii infection in arthritis patients are discussed. Trial registration: This is an epidemiological survey, therefore trial registration was not required

Burnout syndrome in Cypriot physiotherapists: a national survey

Background. Burnout in the healthcare workers is formally defined as a state of physical, emotional and mental exhaustion caused by long-term involvement in situations that are emotionally demanding. Methods. Using a random stratified sampling method and taking into account geographical location, specialty and type of employment, 172 physiotherapists working both in the private and public sectors completed an anonymous questionnaire that included several aspects related to burnout; the MBI scale, questions related to occupational stress, and questions pertaining to self image. Results. Almost half (46%) of the 172 participants believed that their job is stressful. Approximately 57% of the physiotherapists who worked in the public sector and 40% of those who worked in the private sector (p = 0.038) reported that their job is stressful. In total, 21.1% of participants met Maslach's criteria for burnout. The point prevalence of burnout was as follows: (1) 13.8% of those who worked in the public sector and 25.5% of those in the private sector (2) 22.2% of males and 20% of females (3) 21.6% who were married, 18% who were single and 33.3% who were separated. Gender was found to be associated with the level of personal accomplishment (chi-squared test; p = 0.049), as 17.8% of men compared with 24.3% of women reported high personal accomplishment. The number of years of working as a physiotherapist correlated negatively (r = -0.229, p = 0.004) with the total depersonalization score. Regression analysis showed that the perception that the job is stressful (p < 0.001) and the low salary (p = 0.016) were significant predictors of high emotional exhaustion scores, while age group (p = 0.027) predicted high scores of depersonalization and the employment sector (p = 0.050) as well as the low salary predicted high personal accomplishment scores. Conclusions. Burnout levels in physiotherapists in Cyprus ranged from low to moderate

Type IV collagen drives alveolar epithelial-endothelial association and the morphogenetic movements of septation

Background: Type IV collagen is the main component of the basement membrane that gives strength to the blood-gas barrier (BGB). In mammals, the formation of a mature BGB occurs primarily after birth during alveologenesis and requires the formation of septa from the walls of the saccule. In contrast, in avians, the formation of the BGB occurs rapidly and prior to hatching. Mutation in basement membrane components results in an abnormal alveolar phenotype; however, the specific role of type IV collagen in regulating alveologenesis remains unknown. Results: We have performed a microarray expression analysis in late chick lung development and found that COL4A1 and COL4A2 were among the most significantly upregulated genes during the formation of the avian BGB. Using mouse models, we discovered that mutations in murine Col4a1 and Col4a2 genes affected the balance between lung epithelial progenitors and differentiated cells. Mutations in Col4a1 derived from the vascular component were sufficient to cause defects in vascular development and the BGB. We also show that Col4a1 and Col4a2 mutants displayed disrupted myofibroblast proliferation, differentiation and migration. Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. Conclusions: Our study showed that type IV collagen and, therefore the basement membrane, play fundamental roles in coordinating alveolar morphogenesis. In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum

Synchronizing Allelic Effects of Opposing Quantitative Trait Loci Confirmed a Major Epistatic Interaction Affecting Acute Lung Injury Survival in Mice

Increased oxygen (O2) levels help manage severely injured patients, but too much for too long can cause acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and even death. In fact, continuous hyperoxia has become a prototype in rodents to mimic salient clinical and pathological characteristics of ALI/ARDS. To identify genes affecting hyperoxia-induced ALI (HALI), we previously established a mouse model of differential susceptibility. Genetic analysis of backcross and F2 populations derived from sensitive (C57BL/6J; B) and resistant (129X1/SvJ; X1) inbred strains identified five quantitative trait loci (QTLs; Shali1-5) linked to HALI survival time. Interestingly, analysis of these recombinant populations supported opposite within-strain effects on survival for the two major-effect QTLs. Whereas Shali1 alleles imparted the expected survival time effects (i.e., X1 alleles increased HALI resistance and B alleles increased sensitivity), the allelic effects of Shali2 were reversed (i.e., X1 alleles increased HALI sensitivity and B alleles increased resistance). For in vivo validation of these inverse allelic effects, we constructed reciprocal congenic lines to synchronize the sensitivity or resistance alleles of Shali1 and Shali2 within the same strain. Specifically, B-derived Shali1 or Shali2 QTL regions were transferred to X1 mice and X1-derived QTL segments were transferred to B mice. Our previous QTL results predicted that substituting Shali1 B alleles onto the resistant X1 background would add sensitivity. Surprisingly, not only were these mice more sensitive than the resistant X1 strain, they were more sensitive than the sensitive B strain. In stark contrast, substituting the Shali2 interval from the sensitive B strain onto the X1 background markedly increased the survival time. Reciprocal congenic lines confirmed the opposing allelic effects of Shali1 and Shali2 on HALI survival time and provide unique models to identify their respective quantitative trait genes and to critically assess the apparent bidirectional epistatic interactions between these major-effect loci