Fiducia inmobiliaria

El fideicomiso es una figura legal que tiene su origen en el Derecho Romano. Su significado etimológico es el de esperanza cierta y confianza; mientras que en la práctica es tomado como “ fe de encargo “ , mediante el cual una persona transfiere la propiedad de bienes muebles, inmuebles o derechos a una fiduciaria para que ésta los administre de acuerdo a las instrucciones establecidas por el fideicomitente en beneficio de él o de terceros. Existen actualmente proyectos inmobiliarios ya en construcción que pueden dar fe de que el fideicomiso funciona eficientemente, ofreciendo elementos estupendos para atraer la inversión local o extranjera así como fuente generadora de trabajo para amplios sectores de la economía. Estos proyectos atienden demandas en el sector turístico, condominios vacacionales de tiempo compartido en la playa y hoteles; en el sector de la vivienda, complejos urbanísticos en Guayaquil y en Portoviejo; edificios de oficinas, World Trade Center en la Av. Fco. de Orellana en el norte de la ciudad de Guayaquil; Malecón 2000, proyecto que rescata el potencial turístico de nuestra ciudad, entre otros. El éxito de la realización de estos proyectos radica en alcanzar un punto de equilibrio de pre-venta del proyecto, ya que con estos flujos de efectivo el proyecto se viabiliza. Para lograr este cometido son necesarios dos canales de distribución: las Relaciones Públicas y la Venta Directa

Can Valproic Acid be an Inducer of Clozapine Metabolism?

Introduction: Prior clozapine studies indicated no effects, mild inhibition or induction of valproic acid (VPA) on clozapine metabolism. The hypotheses that (i) VPA is a net inducer of clozapine metabolism, and (ii) smoking modifies this inductive effect were tested in a therapeutic drug monitoring study. Methods: After excluding strong inhibitors and inducers, 353 steady-state total clozapine (clozapine plus norclozapine) concentrations provided by 151 patients were analyzed using a random intercept linear model. Results: VPA appeared to be an inducer of clozapine metabolism since total plasma clozapine concentrations in subjects taking VPA were significantly lower (27% lower; 95% confidence interval, 14-39%) after controlling for confounding variables including smoking (35% lower, 28-56%). Discussion: Prospective studies are needed to definitively establish that VPA may (i) be an inducer of clozapine metabolism when induction prevails over competitive inhibition, and (ii) be an inducer even in smokers who are under the influence of smoking inductive effects on clozapine metabolism

Cysteine-proteases and cystatins from barley: molecular and functional characterization in housekeeping and defense processes

Plant cysteine-proteases (CysProt) represent a well-characterized type of proteolytic enzymes that fulfill tightly regulated physiological functions (senescence and seed germination among others) and defense roles. This article is focused on the group of papain-proteases C1A (family C1, clan CA) and their inhibitors, phytocystatins (PhyCys). In particular, the protease–inhibitor interaction and their mutual participation in specific pathways throughout the plant's life are reviewed. C1A CysProt and PhyCys have been molecularly characterized, and comparative sequence analyses have identified consensus functional motifs. A correlation can be established between the number of identified CysProt and PhyCys in angiosperms. Thus, evolutionary forces may have determined a control role of cystatins on both endogenous and pest-exogenous proteases in these species. Tagging the proteases and inhibitors with fluorescence proteins revealed common patterns of subcellular localization in the endoplasmic reticulum–Golgi network in transiently transformed onion epidermal cells. Further in vivo interactions were demonstrated by bimolecular fluorescent complementation, suggesting their participation in the same physiological processes

Mineralogical Characterization and Firing Temperature Delineation on Minoan Pottery, Focusing on the Application of Micro-Raman Spectroscopy

Ceramic objects in whole or in fragments usually account for the majority of findings in an archaeological excavation. Thus, through examination of the values these items bear, it is possible to extract important information regarding raw materials provenance and ceramic technology. For this purpose, either traditional examination protocols could be followed, focusing on the macroscopic/morphological characteristics of the ancient object, or more sophisticated physicochemical techniques are employed. Nevertheless, there are cases where, due to the uniqueness and the significance of an object of archaeological value, sampling is impossible. Then, the available analytical tools are extremely limited, especially when molecular information and mineral phase identification is required. In this context, the results acquired from a multiphase clay ceramic dated on Early Neopalatioal period ΜΜΙΙΙΑ-LMIA (1750 B.C.E.–1490 B.C.E.), from the Minoan Bronze Age site at Philioremos (Crete, Greece) through the application of Raman confocal spectroscopy, a non-destructive/ non-invasive method are reported. The spectroscopic results are confirmed through the application of X-ray microdiffraction and scanning electron microscopy coupled with energy dispersive X-ray spectrometry. Moreover, it is demonstrated how it is made possible through the application of micro-Raman spectroscopy to examine and collect crucial information from very small inclusions in the ceramic fabric. The aim of this approach is to develop an analytical protocol based on mRaman spectroscopy, for extracting firing temperature information from other ceramic finds (figurines) where due to their uniqueness sampling and analyses through other techniques is not possible. This information can lead to dating but also to firing kiln technology extrapolations that are very significant in archaeology

Catalytic pyrolysis of used tires on noble-metal-based catalysts to obtain high-value chemicals: Reaction pathways

A systematic study on the use of noble metals (Pd, Pt, Au) supported on titanate nanotubes (NT-Ti) for selectively producing BTX and p-cymene from waste tire pyrolysis is provided here. All the materials were characterized for chemical, textural and structural properties using a range of analytical techniques. The M/NT-Ti (M: Pd, Pt, or Au) catalysts exhibit low nanoparticle sizes (1.8 Pt ≈ Au > support > non-catalyst. The Py-GC/MS suggest that the catalysts participate in the secondary reactions of dealkylation, dehydrogenation, isomerization, aromatization, and cyclization leading to a higher formation of BTX than the uncatalyzed reaction. Finally, a comprehensive reaction pathway describing the catalytic pyrolysis of WT over Pd/NT-Ti was proposed by studying the catalytic pyrolysis of individual polymers constituting the waste tires, and D,L-Limonene.Puede accederse a los datos primarios de este trabajo haciendo clic en "Documentos relacionados".Centro de Investigación y Desarrollo en Ciencias Aplicada

The Impact of Opuntia ficus-indica and Other Vegetables on Serum Cholesterol and Triglycerides: A Cross-Sectional Analysis

Background: Cholesterol is primarily synthesized in the liver. Treatment with statins and diet regulation are commonly prescribed for people with hypercholesterolemia. Previous claims suggest that the consumption of nopal and other vegetables may have a significant effect on diabetes but scarce is known about its relationship with cholesterol and triglycerides. The aim of this study was to evaluate the impact of nopal and other vegetables on serum cholesterol and triglyceride level in population not related with hypercholesterolemia. Methods: We analyzed a dataset comprising of students from UMAN and their relatives totaling 198 participants. Participants completed an informed consent, filled out questionnaires, anthropometric and serum lipid measurements. A semi-quantitative food questionnaire assessed the frequency and amount of consumption for 56-specific foods. We did a factor analysis with varimax rotation using 7 specific foods we were interested. We conducted linear regression analyses with total cholesterol, LDL-c, and triglycerides as dependent variables. Age, sex, BMI, body fat percentage, and consumption factors (fruits, vegetables, and grains) were included as predictors. Collinearity was assessed using VIF calculations. Results: Approximately 48% of participants consumed nopal on a weekly basis, with most considering their intake to be of median to large amounts, while only 11% reported never consuming nopal. Participants with diabetes showed higher nopal consumption [3.1 (s.e.m. 0.24) vs non-diabetic 2.7 (0.22) vs unknown 1.7 (0.28), p\u3c0.04]. A slight correlation was observed between high self-efficacy in diet and nopal ingestion (rho 0.15, p=0.02), but no significant correlations were found for fruits or grains. Regression analysis revealed that LDL-c was associated with obesity (b=-20, p=0.04) and marginally with body fat percentage (adjusted b=0.83, p=0.069), but not with any of the consumption factors. Total cholesterol was explained by age (adjusted b=0.5, p=0.002) and body fat percentage (b=1.05, p=0.024). HDL-c was marginally associated with sex (Male b=-8.3, p=0.08), while triglycerides were associated with age and obesity (overweight and Class-I, b=0.04, p=0.001 and b=0.04, p=0.04, respectively). No collinearity was found in the analyzed regressions (VIF between 0.1 and 3.4). Conclusion: Our findings suggest that cholesterol and other lipid traits are primarily influenced by genetic factors, with diet playing a minor role. Nopal, vegetables, and fruit showed no significant effects on serum lipid levels in our study. A limitation of our study is its cross-sectional design, and future research could benefit from longitudinal studies with controlled amounts of nopal and other foods

Telomere Lengths, Pulmonary Fibrosis and Telomerase (<i>TERT</i>) Mutations

Background: Telomerase is an enzyme that catalyzes the addition of nucleotides on the ends of chromosomes. Rare loss of function mutations in the gene that encodes the protein component of telomerase (TERT) have been described in patients with idiopathic pulmonary fibrosis (IPF). Here we examine the telomere lengths and pulmonary fibrosis phenotype seen in multiple kindreds with heterozygous TERT mutations.Methods and Findings: We have identified 134 individuals with heterozygous TERT mutations from 21 unrelated families. Available medical records, surgical lung biopsies and radiographs were evaluated retrospectively. Genomic DNA isolated from circulating leukocytes has been used to measure telomere lengths with a quantitative PCR assay. We find that telomere lengths of TERT mutation carriers decrease in an age-dependent manner and show progressive shortening with successive generations of mutation inheritance. Family members without TERT mutations have a shorter mean telomere length than normal, demonstrating epigenetic inheritance of shortened telomere lengths in the absence of an inherited TERT mutation. Pulmonary fibrosis is an age-dependent phenotype not seen in mutation carriers less than 40 years of age but found in 60% of men 60 years or older; its development is associated with environmental exposures including cigarette smoking. A radiographic CT pattern of usual interstitial pneumonia (UIP), which is consistent with a diagnosis of IPF, is seen in 74% of cases and a pathologic pattern of UIP is seen in 86% of surgical lung biopsies. Pulmonary fibrosis associated with TERT mutations is progressive and lethal with a mean survival of 3 years after diagnosis. Overall, TERT mutation carriers demonstrate reduced life expectancy, with a mean age of death of 58 and 67 years for males and females, respectively.Conclusions: A subset of pulmonary fibrosis, like dyskeratosis congenita, bone marrow failure, and liver disease, represents a “telomeropathy” caused by germline mutations in telomerase and characterized by short telomere lengths. Family members within kindreds who do not inherit the TERT mutation have shorter telomere lengths than controls, demonstrating epigenetic inheritance of a shortened parental telomere length set-point.</p

Tecnologia e Competências Tecnológicas em Educação a Distancia: Um Estudo Exploratório

Esta pesquisa teve como objetivo geral identificar os elementos componentes das competências tecnológicas em serviços por meio do estudo do uso da tecnologia e seus impactos nas práticas organizacionais. A abordagem de pesquisa incluiu uma etapa qualitativa, baseada em entrevistas com desenvolvedores, usuários e gestores de tecnologia. A principal contribuição da pesquisa foi a identificação das tecnologias utilizadas a partir de uma perspectiva que reúne tanto a perspectiva do usuário quanto do desenvolvedor, onde são analisados os desdobramentos em termos de práticas organizacionais e desempenho no segmento de Educação a Distância (EAD). A análise das entrevistas sugere que ainda há resistência na adoção da tecnologia e o desenvolvimento da competência tecnológica ainda encontra-se nos estágios iniciais. Nos casos em que a tecnologia é utilizada com intensidade, as mudanças nas práticas e no desempenho ocorrem indistintamente, com benefícios claros em termos de rapidez, eficiência e ganhos de escala