Indicators of Quality of Life in Women with Favorable and Unfavorable Course of Breast Cancer

В работе показаны результаты сравнительного анализа показателей качества жизни у женщин, больных злокачественным новообразованием молочной железы, c благоприятным и неблагоприятным течением болезни. В группу с благоприятным течением болезни включались женщины, больные раком молочной железы, в случае наступления полной ремиссии; стабилизации болезни. В группу женщин с неблагоприятным течением рака молочной железы включались пациенты в случае генерализации процесса, рецидива, прогрессии опухоли. У всей выборки женщин оценивались показатели качества жизни с помощью методики SF‑36. Всего в исследовании приняли участие 202 женщины с диагнозом рака молочной железы. Результаты сравнительного анализа показали отсутствие достоверных различий в показателях качества жизни между группой женщин, больных раком молочной железы, с благоприятным течением заболевания и группой женщин с неблагоприятным течением болезни.The paper shows the results of a comparative analysis of quality of life indicators in women with malignant neoplasm of the breast, with a favorable and unfavorable course of the disease. The group with a favorable course of the disease included women with breast cancer, in case of complete remission; stabilization of the disease. The group of women with an unfavorable course of breast cancer included patients in the case of generalization of the process, relapse, tumor progression. Quality of life indicators were assessed in the entire sample of women using the SF‑36 technique. A total of 202 women with a diagnosis of breast cancer participated in the study. The results of the comparative analysis showed the absence of significant differences in quality of life indicators between a group of women with breast cancer with a favorable course of the disease and a group of women with an unfavorable course of the disease.Исследование выполнено за счет гранта Российского научного фонда №21-18-00434, https://rscf.ru/project/21-18-00434

Non-Leptonic Decays of B Mesons and Strong Coupling Constants

Non-leptonic decays of B mesons into two mesons or meson resonances are studied on the basis of two versions of simple pole-dominance models involving scalar, vector, pseudoscalar and axial-vector poles. The results are compared with those obtained from the usual factorization model and used to obtain information on strong coupling constants between B meson and one light or one charmed meson, respectively. These coupling constants are compared to results from various QCD sum rule calculations.Comment: Latex file 35 pages, including 3 figure

A consistent treatment for pion form factors in space-like and time-like regions

We write down some relevant matrix elements for the scattering and decay processes of the pion by considering a quark-meson vertex function. The pion charge and transition form factors $F_\pi$, $F_{\pi\gamma}$, and $F_{\pi\gamma^*}$ are extracted from these matrix elements using a relativistic quark model on the light-front. We found that, the form factors $F_\pi$ and $F_{\pi\gamma}$ in the space-like region agree well with experiment. Furthermore, the branching ratios of all observed decay modes of the neutral pion, that are related to the form factors $F_{\pi\gamma}$ and $F_{\pi\gamma^*}$ in the time-like region, are all consistent with the data as well. Additionally, $F_\pi$ in the time-like region, which deals with the nonvalence contribution, is also discussed.Comment: 24 pages, 6 figures, to appear in Phys. Rev.

Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke

BACKGROUND AND PURPOSE: Computed tomographic angiography and magnetic resonance angiography are used increasingly to assess arterial patency in patients with ischemic stroke. We determined which baseline angiography features predict response to intravenous thrombolytics in ischemic stroke using randomized controlled trial data. METHODS: We analyzed angiograms from the IST-3 (Third International Stroke Trial), an international, multicenter, prospective, randomized controlled trial of intravenous alteplase. Readers, masked to clinical, treatment, and outcome data, assessed prerandomization computed tomographic angiography and magnetic resonance angiography for presence, extent, location, and completeness of obstruction and collaterals. We compared angiography findings to 6-month functional outcome (Oxford Handicap Scale) and tested for interactions with alteplase, using ordinal regression in adjusted analyses. We also meta-analyzed all available angiography data from other randomized controlled trials of intravenous thrombolytics. RESULTS: In IST-3, 300 patients had prerandomization angiography (computed tomographic angiography=271 and magnetic resonance angiography=29). On multivariable analysis, more extensive angiographic obstruction and poor collaterals independently predicted poor outcome (P1 indicates benefit) in patients with (odds ratio, 2.07; 95% confidence interval, 1.18-3.64; P=0.011) versus without (odds ratio, 0.88; 95% confidence interval, 0.58-1.35; P=0.566) arterial obstruction (P for interaction 0.017). CONCLUSIONS: Intravenous thrombolytics provide benefit to stroke patients with computed tomographic angiography or magnetic resonance angiography evidence of arterial obstruction, but the sample was underpowered to demonstrate significant treatment benefit or harm among patients with apparently patent arteries. CLINICAL TRIAL REGISTRATION: URL: http://www.isrctn.com. Unique identifier: ISRCTN25765518

Heavy- to light-meson transition form factors

Semileptonic heavy -> heavy and heavy -> light meson transitions are studied as a phenomenological application of a heavy-quark limit of Dyson-Schwinger equations. Employing two parameters: E, the difference between the mass of the heavy meson and the effective-mass of the heavy quark; and Lambda, the width of the heavy-meson Bethe-Salpeter amplitude, we calculate f_+(t) for all decays on their entire kinematically accessible t-domain. Our study favours f_B in the range 0.135-0.17 GeV and with E=0.44 GeV and 1/Lambda = 0.14 fm we obtain f_+^{B pi}(0) = 0.46. As a result of neglecting 1/m_c-corrections, we estimate that our calculated values of \rho^2 = 0.87 and f_+^{DK}(0)=0.62 are too low by approximately 15%. However, the bulk of these corrections should cancel in our calculated values of Br(D -> \pi l nu)/Br(D -> K l nu)=0.13 and f_+^{D pi}(0)/f_+^{DK}(0) = 1.16.Comment: 26 pages, 3 figures, REVTE

Впервые диагностированный муковисцидоз у беременной женщины

The article describes a difficult clinical case, when cystic fibrosis was detected in an adult pregnant patient, who had been followed since her childhood due to frequent bronchitis and consequently had a long-term treatment due to unconfirmed pulmonary tuberculosis.Представлен сложный клинический случай выявления муковисцидоза у взрослой беременной пациентки, которая с детства наблюдалась по поводу частых бронхитов, в последующем длительное время лечилась по поводу неподтвержденного туберкулеза легких

Electromagnetic form factors in the light-front formalism and the Feynman triangle diagram: spin-0 and spin-1 two-fermion systems

The connection between the Feynman triangle diagram and the light-front formalism for spin-0 and spin-1 two-fermion systems is analyzed. It is shown that in the limit q+ = 0 the form factors for both spin-0 and spin-1 systems can be uniquely determined using only the good amplitudes, which are not affected by spurious effects related to the loss of rotational covariance present in the light-front formalism. At the same time, the unique feature of the suppression of the pair creation process is maintained. Therefore, a physically meaningful one-body approximation, in which all the constituents are on their mass-shells, can be consistently formulated in the limit q+ = 0. Moreover, it is shown that the effects of the contact term arising from the instantaneous propagation of the active constituent can be canceled out from the triangle diagram by means of an appropriate choice of the off-shell behavior of the bound state vertexes; this implies that in case of good amplitudes the Feynman triangle diagram and the one-body light-front result match exactly. The application of our covariant light-front approach to the evaluation of the rho-meson elastic form factors is presented.Comment: corrected typos in the reference

Measurement of the Ratio of the Vector to Pseudoscalar Charm Semileptonic Decay Rate \Gamma(D+ > ANTI-K*0 mu+ nu)/\Gamma(D+ > ANTI-K0 mu+ nu)

Using a high statistics sample of photo-produced charm particles from the FOCUS experiment at Fermilab, we report on the measurement of the ratio of semileptonic rates \Gamma(D+ > ANTI-K pi mu+ nu)/\Gamma(D+ > ANTI-K0 mu+ nu)= 0.625 +/- 0.045 +/- 0.034. Allowing for the K pi S-wave interference measured previously by FOCUS, we extract the vector to pseudoscalar ratio \Gamma(D+ > ANTI-K*0 mu+ nu)/\Gamma(D+ > ANTI-K0 mu+ nu)= 0.594 +/- 0.043 +/- 0.033 and the ratio \Gamma(D+ > ANTI-K0 mu+ nu)/\Gamma(D+ > K- pi+ pi+)= 1.019 +/- 0.076 +/- 0.065. Our results show a lower ratio for \Gamma(D > K* \ell nu})/\Gamma(D > K \ell nu) than has been reported recently and indicate the current world average branching fractions for the decays D+ >ANTI-K0(mu+, e+) nu are low. Using the PDG world average for B(D+ > K- pi+ pi+) we extract B(D+ > ANIT-K0 mu+ nu)=(9.27 +/- 0.69 +/- 0.59 +/- 0.61)%.Comment: 15 pages, 1 figur

Covariant Light-Front Approach for s-wave and p-wave Mesons: Its Application to Decay Constants and Form Factors

We study the decay constants and form factors of the ground-state s-wave and low-lying p-wave mesons within a covariant light-front approach. Numerical results of the form factors for transitions between a heavy pseudoscalar meson and an s-wave or p-wave meson and their momentum dependence are presented in detail. In particular, form factors for heavy-to-light and B to D** transitions, where D** denotes generically a p-wave charmed meson, are compared with other model calculations. The experimental measurements of the decays B^- to D** pi^- and B to D D**_s are employed to test the decay constants of D**_s and the B to D** transition form factors. The heavy quark limit behavior of the decay constants and form factors is examined and it is found that the requirement of heavy quark symmetry is satisfied. The universal Isgur-Wise (IW) functions, one for s-wave to s-wave and two for s-wave to p-wave transitions, are obtained. The values of IW functions at zero recoil and their slope parameters can be used to test the Bjorken and Uraltsev sum rules.Comment: 59 pages, 6 figures. Version to appear in Phys. Rev. D. Changes are: (i) D_s to phi transition form factors are discussed and compared with the recent FOCUS measurements and (ii) zero mode effects are clarifie