Interracial Interactions and Resource Depletion

Self-control/self-regulation depends on a limited resource. It has been suggested that self-presentation may require self-regulation particularly when familiar or dispositional tendencies must be overridden in order to make desired impressions. The more resources used the less a person has control of his or hers executive functioning. This is especially true for some people during interracial interactions. Recent research finds that interracial interactions can negatively impact executive functioning. This study examined whether the anticipation of an interracial interaction would deplete regulatory resources more in an unstructured than a structured (i.e. scripted) condition. Also examined in this study, was whether participants would feel more positive when they anticipated interaction in a structured discussion with people of a different race than when structure is absent. Contrary to our predictions, the present study failed to support either hypothesis. The data revealed that there was no correlation of regulatory resources, nor the creation of positive feelings in regards to having an interracial interactio

Interracial Interactions and Resource Depletion

Self-control/self-regulation depends on a limited resource. It has been suggested that self-presentation may require self-regulation particularly when familiar or dispositional tendencies must be overridden in order to make desired impressions. The more resources used the less a person has control of his or hers executive functioning. This is especially true for some people during interracial interactions. Recent research finds that interracial interactions can negatively impact executive functioning. This study examined whether the anticipation of an interracial interaction would deplete regulatory resources more in an unstructured than a structured (i.e. scripted) condition. Also examined in this study, was whether participants would feel more positive when they anticipated interaction in a structured discussion with people of a different race than when structure is absent. Contrary to our predictions, the present study failed to support either hypothesis. The data revealed that there was no correlation of regulatory resources, nor the creation of positive feelings in regards to having an interracial interactio

Methicillin-resistant Staphylococcus aureus isolated from various types of hospital infections in pediatrics: Panton-valentine leukocidin, staphylococcal chromosomal cassette mec SCCmec phenotypes and antibiotic resistance properties

Background: Staphylococcus aureus has long been considered as a major pathogen of hospital infections. Objectives: The present investigation was carried out to study the distribution of Staphylococcal Chromosomal Cassette mec (SCCmec) types, Panton-Valentine Leukocidin (PVL) gene and antibiotic resistance properties of Methicillin Resistant Staphylococcus aureus (MRSA) strains isolated from various types of infections found in Iranian pediatric patients. Patients and Methods: Two-hundred and fifty-five clinical specimens were collected from four major provinces of Iran. Samples were cultured and the MRSA strains were subjected to Polymerase Chain Reaction (PCR). The patterns of antibiotic resistance were determined using the disk diffusion method. Results: Seventy-four out of 255 (29.01) clinical samples were positive for MRSA. Of the 74 MRSA strains, 47 (63.51) were PVL positive. The clinical samples of respiratory tract infections (36.36), those from the Shiraz province (37.87) and samples collected during the summer season (56.48) were the most commonly infected samples. The most commonly detected antibiotic resistance genes were tetK (89.18), mecA (71.62), msrA (56.75) and tetM (54.05). Methicillin Resistant Staphylococcus aureus had the highest levels of resistance against penicillin (100), tetracycline (98.64), ampicillin (93.24) and oxacillin (93.24). The most commonly detected SCCmec types in the MRSA strains were type V (18.91) and III (17.56). Conclusions: Regular surveillance of hospital-associated infections and monitoring of the antibiotic sensitivity patterns are required to reduce the prevalence of MRSA. We recommend initial management of children affected by MRSA with imipenem, lincomycin and cephalothin prescriptions. © 2015, Ahvaz Jundishapur University of Medical Sciences

Decrease expression and clinicopathological significance of miR-148a with poor survival in hepatocellular carcinoma tissues

Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide, mainly due to its high rates of postoperative recurrence and metastasis. Please remove, it currently ranks as the third most common cause of cancer-related deaths. MiRNAs are a set of small, single-stranded, non-coding RNA molecules that negatively regulate gene expression at the post-transcriptional level. In this study, we demonstrated the down-regulation of miR-148a in HCC and non-cancerous tissues using qRT-PCR. Methods: Ninety six HCC samples and their noncancerous normal liver tissues were collected. Total mRNA including miRNA was extracted, and miR-148a expression was determined using qRT-PCR. Furthermore, the correlation between the miR-148a expression and clinicopathological parameters was investigated. Results: The result showed that reduction of miR-148a expression was associated with TNM stage, metastasis, and number of tumor nodes. Multivariate Cox proportional hazards model analysis showed that low expression of miR-148a was independently associated with recurrence of HCC in the current study. Moreover, our result showed that lower expression in tumor tissues in comparison with corresponding normal control tissues. Conclusion: Down-regulation of miR-148a is related to HCC carcinogenesis and deterioration of HCC. MicroRNA-148a may act as a suppressor miRNA of HCC, and it is therefore a potential prognostic biomarker for HCC patients. © 2015 Ajdarkosh et al

Doubly Charged Coronene Clusters – Much Smaller than Previously Observed

The smallest doubly charged coronene cluster ions reported so far, Cor152+, were produced by charge exchange between bare coronene clusters and He2+ [H. A. B. Johansson et al., Phys. Rev. A 84, 043201 (2011)]. These dications are at least five times larger than the estimated Rayleigh limit, i.e., the size at which the activation barrier for charge separation vanishes. Such a large discrepancy is unheard of for doubly charged atomic or molecular clusters. Here we report the mass spectrometric observation of doubly charged coronene trimers, produced by electron ionization of helium nanodroplets doped with coronene. The observation implies that Cor32+ features a non-zero fission barrier too large to overcome under the present experimental conditions. The height of the barriers for the dimer and trimer has been estimated by means of density functional theory calculations. A sizeable barrier for the trimer has been revealed in agreement with the experimental findings

Using Facebook Advertisements for Women’s Health Research: Methodology and Outcomes of an Observational Study

BACKGROUND: Recruitment of diverse populations for health research studies remains a challenge. The COVID-19 pandemic has exacerbated these challenges by limiting in-person recruitment efforts and placing additional demands on potential participants. Social media, through the use of Facebook advertisements, has the potential to address recruitment challenges. However, existing reports are inconsistent with regard to the success of this strategy. Additionally, limited information is available about processes that can be used to increase the diversity of study participants. OBJECTIVE: A Qualtrics survey was fielded to ascertain women’s knowledge of and health care experiences related to breast density. This paper describes the process of using Facebook advertisements for recruitment and the effectiveness of various advertisement strategies. METHODS: Facebook advertisements were placed in 2 rounds between June and July 2020. During round 1, multiple combinations of headlines and interest terms were tested to determine the most cost-effective advertisement. The best performing advertisement was used in round 2 in combination with various strategies to enhance the diversity of the survey sample. Advertisement performance, cost, and survey respondent data were collected and examined. RESULTS: In round 1, a total of 45 advertisements with 5 different headlines were placed, and the average cost per link click for each headline ranged from US $0.12 to US$0.79. Of the 164 women recruited in round 1, in total 91.62% were eligible to complete the survey. Advertisements used during recruitment in round 2 resulted in an average cost per link click of US $0.11. During the second round, 478 women attempted the survey, and 87.44% were eligible to participate. The majority of survey respondents were White (80.41%), over the age of 55 years (63.94%), and highly educated (63.71%). CONCLUSIONS: Facebook advertisements can be used to recruit respondents for health research quickly, but this strategy may yield participants who are less racially diverse, more educated, and older than the general population. Researchers should consider recruiting participants through other methods in addition to creating Facebook advertisements targeting underrepresented populations

Hamilton-Jacobi Solutions for Strongly-Coupled Gravity and Matter

A Green's function method is developed for solving strongly-coupled gravity and matter in the semiclassical limit. In the strong-coupling limit, one assumes that Newton's constant approaches infinity. As a result, one may neglect second order spatial gradients, and each spatial point evolves like an homogeneous universe. After constructing the Green's function solution to the Hamiltonian constraint, the momentum constraint is solved using functional methods in conjunction with the superposition principle for Hamilton-Jacobi theory. Exact and approximate solutions are given for a dust field or a scalar field interacting with gravity.Comment: 26 pages Latex (IOP) file with 2 IOP style files, to be published in Classical and Quantum Gravity (1998

IRX4204 Induces Senescence and Cell Death in HER2-Positive Breast Cancer and Synergizes With Anti-HER2 Therapy

PURPOSE: Rexinoids, agonists of nuclear retinoid X receptor (RXR), have been used for the treatment of cancers and are well tolerated in both animals and humans. However, the usefulness of rexinoids in treatment of breast cancer remains unknown. This study examines the efficacy of IRX4204, a highly specific rexinoid, in breast cancer cell lines and preclinical models to identify a biomarker for response and potential mechanism of action. EXPERIMENTAL DESIGN: IRX4204 effects on breast cancer cell growth and viability were determined using cell lines, syngeneic mouse models, and primary patient-derived xenograft (PDX) tumors. In vitro assays of cell cycle, apoptosis, senescence, and lipid metabolism were used to uncover a potential mechanism of action. Standard anti-HER2 therapies were screened in combination with IRX4204 on a panel of breast cancer cell lines to determine drug synergy. RESULTS: IRX4204 significantly inhibits the growth of HER2-positive breast cancer cell lines, including trastuzumab and lapatinib-resistant JIMT-1 and HCC1954. Treatment with IRX4204 reduced tumor growth rate in the MMTV-ErbB2 mouse and HER2-positive PDX model by 49% and 44%, respectively. Mechanistic studies revealed IRX4204 modulates lipid metabolism and induces senescence of HER2-positive cells. In addition, IRX4204 demonstrates additivity and synergy with HER2-targeted mAbs, tyrosine kinase inhibitors, and antibody-drug conjugates. CONCLUSIONS: These findings identify HER2 as a biomarker for IRX4204 treatment response and demonstrate a novel use of RXR agonists to synergize with current anti-HER2 therapies. Furthermore, our results suggest that RXR agonists can be useful for the treatment of anti-HER2 resistant and metastatic HER2-positive breast cancer

Stabilization of the Yang-Mills chaos in non-Abelian Born-Infeld theory

We investigate dynamics of the homogeneous time-dependent SU(2) Yang-Mills fields governed by the non-Abelian Born-Infeld lagrangian which arises in superstring theory as a result of summation of all orders in the string slope parameter $\alpha'$. It is shown that generically the Born-Infeld dynamics is less chaotic than that in the ordinary Yang-Mills theory, and at high enough field strength the Yang-Mills chaos is stabilized. More generally, a smothering effect of the string non-locality on behavior of classical fields is conjectured.Comment: 7 pages, 5 figure

Axially Symmetric Bianchi I Yang-Mills Cosmology as a Dynamical System

We construct the most general form of axially symmetric SU(2)-Yang-Mills fields in Bianchi cosmologies. The dynamical evolution of axially symmetric YM fields in Bianchi I model is compared with the dynamical evolution of the electromagnetic field in Bianchi I and the fully isotropic YM field in Friedmann-Robertson-Walker cosmologies. The stochastic properties of axially symmetric Bianchi I-Einstein-Yang-Mills systems are compared with those of axially symmetric YM fields in flat space. After numerical computation of Liapunov exponents in synchronous (cosmological) time, it is shown that the Bianchi I-EYM system has milder stochastic properties than the corresponding flat YM system. The Liapunov exponent is non-vanishing in conformal time.Comment: 18 pages, 6 Postscript figures, uses amsmath,amssymb,epsfig,verbatim, to appear in CQ