Using Interval Constrained Petri Nets and Fuzzy Method for Regulation of Quality: The Case of Weight in Tobacco Factory

The existence of maximal durations drastically modifies the performance evaluation in Discrete Event Systems (DES). The same particularity may be found on systems where the associated constraints do not concern the time. For example weight measures, in chemical industry, are used in order to control the quantity of consumed raw materials. This parameter also takes a fundamental part in the product quality as the correct transformation process is based upon a given percentage of each essence. Weight regulation therefore increases the global productivity of the system by decreasing the quantity of rejected products. In this paper we present an approach based on mixing different characteristics theories, the fuzzy system and Petri net system to describe the behaviour. An industriel application on a tobacco manufacturing plant, where the critical parameter is the weight is presented as an illustration

Agglomerated novel spray-dried lactose-leucine tailored as a carrier to enhance the aerosolization performance of salbutamol sulfate from DPI formulations

Spray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study, L-leucine with varying concentrations (0.1, 0.5, 1, 5, and 10% w/v) were incorporated into lactose monohydrate solution for spray-drying to enhance the aerosolization performance of dry powder inhalers containing spray-dried lactose-leucine and salbutamol sulfate. The prepared spray-dried lactose-leucine carriers were analyzed using laser diffraction (particle size), differential scanning calorimetry (thermal behavior), scanning electron microscopy (morphology), powder X-ray diffraction (crystallinity), Fourier transform infrared spectroscopy (interaction at molecular level), and in vitro aerosolization performance (deposition). The results showed that the efficacy of salbutamol sulfate’s aerosolization performance was, in part, due to the introduction of L-leucine in the carrier, prior to being spray-dried, accounting for an increase in the fine particle fraction (FPF) of salbutamol sulfate from spray-dried lactose-leucine (0.5% leucine) in comparison to all other carriers. It was shown that all of the spray-dried carriers were spherical in their morphology with some agglomerates and contained a mixture of amorphous, α-lactose, and β-lactose. It was also interesting to note that spray-dried lactose-leucine particles were agglomerated during the spray-drying process to make coarse particles (volume mean diameter of 79 to 87 μm) suitable as a carrier in DPI formulations

Agreeing to disagree: uncertainty management in assessing climate change, impacts and responses by the IPCC

Dealing consistently with risk and uncertainty across the IPCC reports is a difficult challenge. Huge practical difficulties arise from the Panel’s scale and interdisciplinary context, the complexity of the climate change issue and its political context. The key question of this paper is if the observed differences in the handling of uncertainties by the three IPCC Working Groups can be clarified. To address this question, the paper reviews a few key issues on the foundations of uncertainty analysis, and summarizes the history of the treatment of uncertainty by the IPCC. One of the key findings is that there is reason to agree to disagree: the fundamental differences between the issues covered by the IPCC’s three interdisciplinary Working Groups, between the type of information available, and between the dominant paradigms of the practitioners, legitimately lead to different approaches. We argue that properly using the IPCC’s Guidance Notes for Lead Authors for addressing uncertainty, adding a pedigree analysis for key findings, and particularly communicating the diverse nature of uncertainty to the users of the assessment would increase the quality of the assessment. This approach would provide information about the nature of the uncertainties in addition to their magnitude and the confidence assessors have in their finding