A perspective on the Healthgrid initiative

This paper presents a perspective on the Healthgrid initiative which involves European projects deploying pioneering applications of grid technology in the health sector. In the last couple of years, several grid projects have been funded on health related issues at national and European levels. A crucial issue is to maximize their cross fertilization in the context of an environment where data of medical interest can be stored and made easily available to the different actors in healthcare, physicians, healthcare centres and administrations, and of course the citizens. The Healthgrid initiative, represented by the Healthgrid association (http://www.healthgrid.org), was initiated to bring the necessary long term continuity, to reinforce and promote awareness of the possibilities and advantages linked to the deployment of GRID technologies in health. Technologies to address the specific requirements for medical applications are under development. Results from the DataGrid and other projects are given as examples of early applications.Comment: 6 pages, 1 figure. Accepted by the Second International Workshop on Biomedical Computations on the Grid, at the 4th IEEE/ACM International Symposium on Cluster Computing and the Grid (CCGrid 2004). Chicago USA, April 200

14-Bit and 2GS/s Low Power Digitizing Boards for Physics Experiments

International audienceThe trend in data acquisition systems for modern physics experiments is to digitize analog signals closer and closer to the detector. The digitization systems have followed the progress of commercial analog to digital converters. The state of the art for these devices is currently 200 MSample/s for a 14-bit range. The new boards, described in this paper, have been designed to improve these performances by more than an order of magnitude. This board mainly includes 4 channels sampling analog data up to 2 GSamples/s with an analog bandwidth of 300 MHz, and digitizing it with a 14-bit dynamic range. It is based on the custom-designed MATACQ chip. The latter's innovative design permits reaching these performances with power consumption smaller than 1W, thus allowing a total consumption below 20W for the whole board. The board is triggerable either by internal or external signals and several boards are easily synchronizable. The board integrates USB, GPIB and VME interfaces that permit a readout speed of up to 500 events/s with the whole memory depth of the 4 channels read

Modification of carbon by diazonium salts: control using a radical scavenger

Grafting of organic structures using the diazonium chemistry is a recognized method for obtaining functionalized surfaces.1 Various conducting materials as metals and carbon can be modified in aprotic or aqueous media, and provide covalently tethered layers. The efficiency of this grafting process rests upon the high reactivity of the aryl radicals produced at the electrode-solution interface. This reactivity leads to the generation of polyaryl layers via the radicalar attack of already grafted aryl species on the surface. As a consequence, the method routinely provides disordered organic films having a thickness varying from one to fifty nanometers. The lack of control, in terms of thickness and organization, represents the major drawback of this elegant and versatile technique. A simple strategy to avoid the formation of polyaryl layer during the functionalization of carbon surface by diazonium reduction is presented.2 The approach proposes to directly act on the polymerization mechanism by the use of a radical scavenger (DPPH = 2,2-diphenyl-1-picrylhydrazyl). The kinetic gap between the surface coupling and the multilayer formation is exploited to prevent the growth of the layer without interfering with the grafting

Picosecond time measurement using ultra fast analog memories

International audienceThe currently existing electronics dedicated to precise time measurement is mainly based on the use of constant fraction discriminators (CFD) associated with Time to Digital Converters (TDC). The constant fraction technique minimizes the time walk effect (dependency of timing on the pulse amplitude). Several attempts have been made to integrate CFD in multi-channel ASICs. But the time resolution measured on the most advanced one is of the order of 30 ps rms. Two main techniques are used for the TDC architectures. The first one makes use of a voltage ramp started or stopped by the digital pulse. The obtained voltage is converted into digital data using an Analog to Digital Converter (ADC). The timing resolution of such a system is excellent (5 ps rms). But this technique is limited by its large dead time which can be unacceptable for the future high rate experiments. Another popular technique associates a coarse measurement performed by a digital counter with a fine measurement (interpolation) using Delay Line Loop. Such a system can integrate several (8-16) channels on an FPGA or an ASIC. The most advanced DLL-based TDC ASIC exhibits a timing resolution of 25 ps, but only after a careful calibration. It should be noticed that the overall timing resolution is given by the quadratic sum of the discriminator and of the TDC. In the meantime, alternative methods based on digital treatment of the analogue sampled then digitized detector signal have been developed. Such methods permit achieving a timing resolution far better than the sampling frequency. For example, 100ps rms resolution has been reported for a signal sampled at only 100MHz. Digitization systems have followed the progress of commercial ADCs, which currently offer a rate of 500 MHz over 12 bits. Their main drawbacks are the huge output data rate and power consumption. Their packaging, cooling, and tricky clock requirements also makes them very hard to implement. Conversely, high speed analog memories now offer sampling rates far above 1GHz at low cost and with low power consumption. The new USB-WaveCatcher board has been designed to provide high performances over a short time window. It houses on a small surface two 12-bit 500-MHz-bandwidth digitizers sampling between 400 MS/s and 3.2 GS/s. It is based on the patented SAM chip, an analog circular memory of 256 cells per channel. Its innovative matrix design permits reaching these performances, yet in a cheap pure CMOS 0.35µm technology, while consuming only 300 mW. Raw sampling precision is as good as 15ps rms. In an embodiment where the clock is directly sent to the SAM chip, thus limiting the usable sampling frequency to 3.2GHz, and after a calibration of the fixed pattern time distribution, a reproducible time precision of a few ps has been demonstrated. The board also offers various functionalities. Its input offset is tunable over a range of 2 V. It can be triggered either internally or externally and several boards can easily be synchronized. Trigger rates counters are implemented. Both channels can also be used for reflectometry thanks to their internal pulser. The precision obtained for cable length measurements is as good as 2mm. Charge measurement mode is also provided, through integrating on the fly over a programmable time window the signal coming for instance from photo-multipliers. Power consumption is only 2.5 W which permits powering with the sole USB. Signal connectors can be BNC, SMA or LEMO. The board houses a USB 12 Mbits/s interface permitting a dual-channel readout speed of 500 events/s. Faster readout modes are also available. In charge measurement mode, the sustained trigger rate can reach a few tens kHz. A 480Mbits/s version will soon be available. Various evolutions of the SAM chip are under study, targeting either higher precision time measurements or longer time window. The USB-WaveCatcher can thus replace oscilloscopes for a much lower cost in most high-precision short-window applications. Moreover, it opens new doors into the domain of very high precision time measurements

Electrocatalytic activity of nitroxyl mixed self-assembled monolayers: combined effects of the nanoscale organization and the composition

The aim of this article is to demonstrate that the composition and distribution of electroactive species immobilized on a gold surface can have a significant influence on the reactivity of modified surfaces. It will be shown that on mixed SAMs, where the electroactive species (TEMPO) are diluted with alkanethiols of different lengths, the contribution of the surface distribution on the electrocatalytic activity is as important as the composition. Without any information on the distribution of species within the monolayer, the interpretation of results cannot be reliable

Modified reaction centers from Rhodobacter sphaeroides R26

Incubation of photosynthetic reaction centers from Rhodobacter sphaeroides R26 with exogenous 132-OH-bacteriochlorophyll ap or aGG according to Scheer et al. (1987) results in the exchange of endogenous bacteriochlorophyll ap. The exchange amounts to less-than-or-equals, slant 50% according to HPLC analysis, corresponding to a complete replacement of the ‘monomeric’ bacteriochlorophylls, bm and bl, by exogenous pigment. The absorption spectra show small, but distinct changes in the Qx-region of the bacteriochlorophylls, and bleaching of the modified reaction centers is retained. The corresponding binding sites must be accessible from the exterior, and allow for the introduction of a polar residue at C-132. This is supported by the observation of side reactions of the endogenous ‘monomeric’ bacteriochlorophylls within the reaction center pigments, e.g. epimerization and hydroxylation at C-132

Grafting via diazonium chemistry: controlling the multilayer formation by using radical scavengers

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Electrografting via Diazonium Chemistry: From Multilayer to Monolayer Using Radical Scavenger

A simple strategy to avoid the formation of polyaryl layer during the functionalization of carbon surface by diazonium electroreduction is presented. The approach proposes to directly act on the polymerization mechanism by the use of a radical scavenger. The kinetic gap between the surface coupling and the multilayer formation is exploited to prevent the growth of the layer without interfering with the grafting. The well-known 4-nitrobenzenediazonium electrografting was used to demonstrate the possibility of reaching a monolayer surface coverage with an excess of DPPH (2,2-diphenyl-1-picrylhydrazyl). Experimental conditions were varied to validate the efficiency of the grafting limitation and the radical capture was confirmed by isolation of the aryl radical/DPPH coupling product