Reproducibility or Producibility? Metrics and their masters

Reproducibility of indicators and metrics is an important topic as it underlies an increasing part of the approach taken to research evaluation. But reproducibility of metrics is not the critical question. The more important question is around access to the data to create metrics, and around who owns the metrics and the transparency of the algorithms and data elements. In short, is it not about producibility rather than reproducibility? With Dimensions, Digital Science has taken a first step in making publication and citation data more openly available. But, perhaps more importantly, Dimensions links other types of data to the familiar bibliometrics landscape to allow the community to go beyond citation-based indicators. The team at Digital Science believes in the “separation of powers” - data should be developed and hosted by providers and the community should own the metrics used to measure itself. Work has started to collaborate with the scientometric and research management community to support their development and implementation of metrics based on the Dimensions data and platform

Neuroticism and introversion personality charateristics and adolescents’ school social adjustment in a social inclusion in northern education zone of Cross River State

This study was undertaken to determine the influence of Neuroticism and introversion Personality Factors on Adolescents’ School Social Adjustment in a social Inclusion Education, in Northern Education Zone of Cross River State, Nigeria. The sample for the study consists of one thousand and eighteen (1018) students who were randomly selected from senior secondary one classes (SS1) in nineteen (19) purposively selected schools out of the seventy-three (73) schools in the study area. The researcher adopted a causal comparative design also known as the ex-post facto, and data were collected using NEO-PI scale and school social adjustment questionnaire as the main instrument. To guide the study, two research questions were raised and two statement of hypotheses were postulated and tested at 0.05 levels of significant using independent t-test and one-way analysis of variance (ANOVA) statistic. The results from the analyzed data indicated that there is significant difference of neuroticism on early adolescent’s school social adjustment. Sidak post hoc test was performed to show where the difference lies; also, introverts significantly differ from extroverts regarding their school social adjustment. In view of the above findings, it was concluded that Neuroticism factor is significantly related to adolescents’ school social adjustment in the study area in an inclusive education. It was recommended among others, that the effort of teachers, parents, educational psychologist, guidance counselors and the government are needful in all secondary schools to help students overcome the problem of poor adjustments in schools

Structure-based drug design of 11β-hydroxysteroid dehydrogenase type 1 inhibitors

The enzyme 11β-Hydroxysteroid Dehydrogenase 1 (11β-HSD1) catalyses the intracellular biosynthesis of the active glucocorticoid cortisol. Tissue specific dysregulation of the enzyme has been implicated in the development of metabolic syndrome and other associated diseases. Experiments with transgenic mice and prototype inhibitors show that inhibition of 11β-HSD1 in visceral adipose tissue and liver leads to a resistance of diet-induced hyperglycemia and a favourable lipid and lipoprotein profile as compared to controls. 11β-HSD1 inhibition has thus been proposed as an effective strategy to decrease intracellular glucocorticoid levels without affecting circulating glucocorticoid levels that are essential for stress responses. The clinical development of selective and potent drugs has therefore become a priority. In this research, a process of virtual screening employing the novel algorithm UFSRAT (Ultra Fast Shape Recognition with Atom Types) was used to discover compounds which had specific physicochemical and spatial atomic parameters deemed essential for inhibition of 11β-HSD1. The top scoring compounds were assayed for inhibitory activity against recombinant human and mouse enzyme, using a fluorescence spectroscopy approach. In addition, HEK-293 cell based assays with either human, mouse or rat enzymes were carried out using a scintillation proximity assay (SPA). The most potent compound competitively inhibited human 11β-HSD1 with a Kiapp value of 51 nM. Recombinant mouse and human enzyme were expressed, purified and characterised and used in a series of ligand binding assays. Further to this, an X-ray crystal structure of mouse 11β-HSD1 in complex with a tight binding inhibitor – carbenoxolone was solved

Feasibility and safety of combining repetitive transcranial magnetic stimulation and quadriceps strengthening exercise for chronic pain in knee osteoarthritis: A study protocol for a pilot randomised controlled trial

Introduction Knee osteoarthritis is a leading cause of disability, resulting in pain and reduced quality of life. Exercise is the cornerstone of conservative management but effects are, at best, moderate. Early evidence suggests that repetitive transcranial magnetic stimulation (rTMS) applied over the primary motor cortex (M1) may improve the effect of exercise in knee osteoarthritis. This pilot study aims to (1) determine the feasibility, safety and participant-rated response to an intervention adding M1 rTMS to exercise in knee osteoarthritis; (2) elucidate physiological mechanisms in response to the intervention; (3) provide data to conduct a sample size calculation for a fully powered trial. Methods and analysis This is a pilot randomised, assessor-blind, therapist-blind and participant-blind, sham-controlled trial. Thirty individuals with painful knee osteoarthritis will be recruited and randomly allocated to receive either: (1) active rTMS+exercise or (2) sham rTMS+exercise intervention. Participants will receive 15 min of either active or sham rTMS immediately prior to 30 min of supervised muscle strengthening exercise (2×/week, 6 weeks) and complete unsupervised home exercises. Outcome measures of feasibility, safety, pain, function and physiological mechanisms will be assessed before and/or after the intervention. Feasibility and safety will be analysed using descriptive analysis. Within-group and between-group comparisons of pain and function will be conducted to examine trends of efficacy. Ethics and dissemination This study has been approved by the University of New South Wales Human Research Ethics Committee (HC210954). All participants will provide written informed consent. The study results will be submitted for peer-reviewed publication. Trial registration number ACTRN12621001712897p