Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway

Nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator that promotes the transcription of cytoprotective genes in response to oxidative/electrophilic stress. Various Michael-type compounds were designed and synthesized, and their potency to activate the Keap1/Nrf2/ARE pathway was evaluated. Compounds bearing two Michael-type acceptors proved to be the most active. Tether length and rigidity between the acceptors was crucial. This study will help to understand how this feature disrupts the interaction between Keap1 and Nrf2

General C–H Arylation Strategy for the Synthesis of Tunable Visible Light-Emitting Benzo[<i>a</i>]imidazo[2,1,5‑<i>c</i>,<i>d</i>]indolizine Fluorophores

Herein we report the discovery of the benzo­[<i>a</i>]­imidazo­[2,1,5-<i>c</i>,<i>d</i>]­indolizine motif displaying tunable emission covering most of the visible spectrum. The polycyclic core is obtained from readily available amides via a chemoselective process involving Tf₂O-mediated amide cyclodehydration, followed by intramolecular C–H arylation. Additionally, these fluorescent heterocycles are easily functionalized using electrophilic reagents, enabling divergent access to varied substitution. The effects of said substitution on the compounds’ photophysical properties were rationalized by density functional theory calculations. For some compounds, emission wavelengths are directly correlated to the substituent’s Hammett constants. Easily introduced nonconjugated reactive functional groups allow the labeling of biomolecules without modification of emissive properties. This work provides a straightforward platform for the synthesis of new moderately bright fluorescent dyes remarkable for their chemical stability, predictability, and unusually high excitation–emission differential

Habiter le Grand Paris ! Ou? Quand? Comment?

Face à ces questions sensibles pour l’avenir du Grand Paris, les 15 équipes pluridisciplinaires, d’architectes, d’urbanistes et de chercheurs qui composent le Conseil scientifique de l’Atelier International du Grand Paris, présentent les résultats de leur recherches, leurs analyses et leurs propositions. Ces réflexions, qui donneront lieu à la parution d’un livre, constituent autant d’éclairages pour répondre aux enjeux métropolitains et aux défis quantitatifs et qualitatifs de l’évolution du logement et des modes d’habiter dans le Grand Paris. &gt; du 1er au 7 juillet : Une exposition organisée autour de films courts réalisés par les quinze équipes de l’AIGPainsi qu’autour de parcours de trois photographes de l’agence Magnum dans le Grand Paris : Patrick Zachmann, Marc Power et Olivia Arthur. • La restitution d’ateliers participatifs organisés par des équipes de l’AIGP sur des territoires du Grand Paris

Firefly: The Case for a Holistic Understanding of the Global Structure and Dynamics of the Sun and the Heliosphere

This white paper is on the HMCS Firefly mission concept study. Firefly focuses on the global structure and dynamics of the Sun's interior, the generation of solar magnetic fields, the deciphering of the solar cycle, the conditions leading to the explosive activity, and the structure and dynamics of the corona as it drives the heliosphere