Computerized tomographic determination of spinal bone mineral content

The aims of the study were three-fold: to determine the magnitude of vertebral cancellous mineral loss in normal subjects during bedrest, to compare this loss with calcium balance and mineral loss in peripheral bones, and to use the vertebral measurements as an evaluative criterion for the C12MDP treatment and compare it with other methods. The methods used are described and the results from 14 subjects are presented

Experiment K-6-04. Trace element balance in rats during spaceflight

Exposure to microgravity causes alterations in the skeletal and mineral homeostatic systems. Little is known about the effects of flight in an older skeleton; limited data suggest that bone resorption is increased after 5 days but no data are available about other metabolic effects. The response of a more slowly-growing skeleton to microgravity may be different than that of a younger animal, similar to the different responses seen in adolescents and adult humans to immobilization. This experiment was designed to investigate changes occurring in skeletal and mineral homeostatis in these older rats flown for two weeks in space. We may expect that the two portions of the rat vertebra, the vertebral body and the posterior elements, will show different responses to spaceflight. The results of the analyses from this study confirm major differences between portions of the vertebra. The posterior bone is more highly mineralized, evidenced by increased concentration (per unit weight of bone) of calcium (5 percent), phosphorus (6 percent) and osteocalcin (37 percent), similar to the differences seen between proximal and mid humerus in previous studies. The major increase in osteocalcin content indicates the presence of mature, low-turnover bone. The difference between flight and control animals were minimal in these older, slower-growing rats. Mass of whole vertebrae increased 6.2 percent in synchronous rats compared to less than 2 percent in flight rats over the 16 days when compared to basal controls, suggesting a decreased rate of bone growth in flight. Compared to young rats in which vertebral mass increased over 40 percent in 10 days in controls and 20 percent in flight rats, this may be a clear indication that even in the older skeleton bone growth will slow in microgravity

A 14-day ground-based hypokinesia study in nonhuman primates: A compilation of results

A 14 day ground based hypokinesia study with rhesus monkeys was conducted to determine if a spaceflight of similar duration might affect bone remodeling and calcium homeostatis. The monkeys were placed in total body casts and sacrificed either immediately upon decasting or 14 days after decasting. Changes in vertebral strength were noted and further deterioration of bone strength continued during the recovery phase. Resorption in the vertebrae increased dramatically while formation decreased. Cortical bone formation was impaired in the long bones. The immobilized animals showed a progressive decrease in total serum calcium which rebounded upon remobilization. Most mandibular parameters remained unchanged during casting except for retardation of osteon birth or maturation rate and density distribution of matrix and mineral moieties

Completability vs (In)completeness

In everyday conversation, no notion of “complete sentence” is required for syntactic licensing. However, so-called “fragmentary”, “incomplete”, and abandoned utterances are problematic for standard formalisms. When contextualised, such data show that (a) non-sentential utterances are adequate to underpin agent coordination, while (b) all linguistic dependencies can be systematically distributed across participants and turns. Standard models have problems accounting for such data because their notions of ‘constituency’ and ‘syntactic domain’ are independent of performance considerations. Concomitantly, we argue that no notion of “full proposition” or encoded speech act is necessary for successful interaction: strings, contents, and joint actions emerge in conversation without any single participant having envisaged in advance the outcome of their own or their interlocutors’ actions. Nonetheless, morphosyntactic and semantic licensing mechanisms need to apply incrementally and subsententially. We argue that, while a representational level of abstract syntax, divorced from conceptual structure and physical action, impedes natural accounts of subsentential coordination phenomena, a view of grammar as a “skill” employing domain-general mechanisms, rather than fixed form-meaning mappings, is needed instead. We provide a sketch of a predictive and incremental architecture (Dynamic Syntax) within which underspecification and time-relative update of meanings and utterances constitute the sole concept of “syntax”

Using Nonlinear Response to Estimate the Strength of an Elastic Network

Disordered networks of fragile elastic elements have been proposed as a model of inner porous regions of large bones [Gunaratne et.al., cond-mat/0009221, http://xyz.lanl.gov]. It is shown that the ratio $\Gamma$ of responses of such a network to static and periodic strain can be used to estimate its ultimate (or breaking) stress. Since bone fracture in older adults results from the weakening of porous bone, we discuss the possibility of using $\Gamma$ as a non-invasive diagnostic of osteoporotic bone.Comment: 4 pages, 4 figure

Fabrication of photonic band gap crystal using microtransfer molded templates

We have proposed and demonstrated an economical technique to fabricate a three-dimensional layer-by-layer photonic band gapstructure in the infrared wavelengths. An organic polymer template structure, an inverse layer-by-layer photonic crystalstructure, is assembled using the microtransfer molding technique. This template is infiltrated with sol-gel or nanoparticle titanium oxide slurry, then later removed by heat treatment at a temperature range of 550–800 °C. This method can be extended to fabricatephotonic crystals operating at optical and ultraviolet frequencies

Effect of Particle Size on Droplet Infiltration into Hydrophobic Porous Media As a Model of Water Repellent Soil

The wettability of soil is of great importance for plants and soil biota, and in determining the risk for preferential flow, surface runoff, flooding,and soil erosion. The molarity of ethanol droplet (MED) test is widely used for quantifying the severity of water repellency in soils that show reduced wettability and is assumed to be independent of soil particle size. The minimum ethanol concentration at which droplet penetration occurs within a short time (≤10 s) provides an estimate of the initial advancing contact angle at which spontaneous wetting is expected. In this study, we test the assumption of particle size independence using a simple model of soil, represented by layers of small (0.2–2 mm) diameter beads that predict the effect of changing bead radius in the top layer on capillary driven imbibition. Experimental results using a three-layer bead system show broad agreement with the model and demonstrate a dependence of the MED test on particle size. The results show that the critical initial advancing contact angle for penetration can be considerably less than 90° and varies with particle size, demonstrating that a key assumption currently used in the MED testing of soil is not necessarily valid

Matrix-assisted laser desorption ionization hydrogen/deuterium exchange studies to probe peptide conformational changes

AbstractHydrogen/deuterium (H/D) exchange chemistry monitored by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is used to study solution phase conformational changes of bradykinin, α-melanocyte stimulating hormone, and melittin as water is added to methanol-d4, acetonitrile, and isopropanol-d8 solutions. The results are interpreted in terms of a preference for the peptides to acquire more compact conformations in organic solvents as compared to the random conformations. Our interpretation is supported by circular dichroism spectra of the peptides in the same solvent systems and by previously published structural data for the peptides. These results demonstrate the utility of MALDI-TOF as a method to monitor the H/D exchange chemistry of peptides and investigations of solution-phase conformations of biomolecules

Central role of detachment faults in accretion of slow-spreading oceanic lithosphere

Author Posting. © Macmillan Publishers, 2008. This is the author's version of the work. It is posted here by permission of Macmillan Publishers for personal use, not for redistribution. The definitive version was published in Nature 455 (2008): 790-794, doi:10.1038/nature07333.The formation of oceanic detachment faults is well established from inactive, corrugated fault planes exposed on seafloor formed along ridges spreading at less than 80 km/My1-4. These faults can accommodate extension for up to 1-3 Myrs5, and are associated with one of two contrasting modes of accretion operating along the northern Mid-Atlantic Ridge (MAR). The first is symmetrical accretion, dominated by magmatic processes with subsidiary high-angle faulting and formation of abyssal hills on both flanks. The second is asymmetrical accretion involving an active detachment fault6 along one ridge flank. An examination of ~2500 km of the MAR between 12.5 and 35°N reveals asymmetrical accretion along almost half of the ridge. Hydrothermal activity identified to date in the study region is closely associated with asymmetrical accretion, which also exhibits high-levels of near continuous hydroacoustically and teleseismically recorded seismicity. Enhanced seismicity is probably generated along detachment faults accommodating a sizeable proportion of the total plate separation. In contrast, symmetrical segments have lower levels of seismicity, which concentrates primarily at their ends. Basalts erupted along asymmetrical segments have compositions that are consistent with crystallization at higher pressures than basalts from symmetrical segments, and with lower extents of partial melting of the mantle. Both seismic and geochemical evidence indicate that the axial lithosphere is thicker and colder at asymmetrical sections of the ridge, either because associated hydrothermal circulation efficiently penetrates to greater depths, or because the rising mantle is cooler. We suggest that much of the variability in seafloor morphology, seismicity and basalt chemistry found along slow-spreading ridges can be thus attributed to the frequent involvement of detachments in oceanic lithospheric accretion.Supported by CNRS (JE), NSF (DKS, HS, JC, CL and SE), WHOI (JE, DKS, HS and JC), Harvard University (JE, CL and SE), Univ. of Leeds (JC), and MIT (JE)