Neurosurgical stereomorphometry in vivo - method description and error measurement

Rules of geometry and stereomorphometry are often applied to narrow and deep neurosurgical approaches. Methods of research are based on the direct cadaver measurements, radiological analysis and intraoperative measurements. Newly developed devices allow direct morphometry to be performed in vivo, during the operation. We describe the use of the neuronavigation system Stealth Station by Medtronic for such stereomorphometric measurements and evaluate the precision of the described method

Expression pattern of ISL-1, TTF-1 and PAX5 in olfactory neuroblastoma

Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated. TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63.64%, h-score: 23-200), and in 3/11 cases (27.77%, h-score 3-85), respectively. The patient with the strongest PAX5 reactivity exhibited an aggressive clinical course with rapid dissemination to the spine and death shortly after the diagnosis. No significant correlation in the expression of PAX5 and TTF-1 (ρ = 0.43; p = 0.18) was observed. ISL-1 is widely expressed in tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis. TTF-1 positivity does not exclude the diagnosis of primary ONB, although usually only a small percentage of cells are positive. PAX5 expression is infrequent (27.27%) in ONB; however, if present it can be associated with a very aggressive clinical course

Uncovertebral joints – their structure, development and relationships with intervertebral discs of cervical spine

Uncovertebral joints, also referred to as Luschka’s joints, are found from the level of second cervical vertebra down to first or second thoracic vertebra. In adults, they appear as regular spaces in annulus fibrosus between the uncinate processes and round edges of vertebral body above. Their development remains in close relationship with changes occurring in intervertebral discs. The joint space, which is formed by the fissure into the fibrocartilaginous core of the intervertebral disc, widens medially at its rear aspect for a various distance. In aged spines, this space extends into additional, smaller lateral fissures, vast and irregular in shape. It is believed that the changes in the uncinate process’ structure are the outcome of progressing dehydration and narrowing of the intervertebral discs of cervical spine. This results in remodeling of the process, which begins to expand and flatten with age. According to many authors, uncovertebral joints are small synovial articulations, that aren’t yet noticeable at age of 6 to 9 and become fully developed before the age of 18.There is some controversy on whether they should be classified as true synovial joints. Some researchers claim that they’re an outcome of degenerative processes occurring within the intervertebral discs and therefore shouldn’t be treated as a product of natural development. The presence of synovial tissue within the joints has been a point of some discussions. Recent studies conclusively shown the presence of synoviocytes in the lateral joint capsule tissue of elderly uncovertebral articulations.The purpose of this paper is to describe the structure, development and relationships of uncovertebral joints with intervertebral discs of cervical spine

Analiza skuteczności terapeutycznej metody MDT McKenzie zastosowanej w leczeniu zespołu zaburzeń strukturalnych w odcinku szyjnym kręgosłupa u 26-letniego mężczyzny – opis przypadku = Analysis of therapeutic efficacy of MDT McKenzie method used in the treatment of cervical spine structural disorders in a 26-year-old man - a case report

Porzych Piotr, Pyskir Małgorzata, Ratuszek-Sadowska Dorota, Dzierżanowski Maciej, Trela Ewa, Nowacka Krystyna, Hagner‑Derengowska Magdalena. Analiza skuteczności terapeutycznej metody MDT McKenzie zastosowanej w leczeniu zespołu zaburzeń strukturalnych w odcinku szyjnym kręgosłupa u 26-letniego mężczyzny – opis przypadku = Analysis of therapeutic efficacy of MDT McKenzie method used in the treatment of cervical spine structural disorders in a 26-year-old man - a case report. Journal of Education, Health and Sport. 2016;6(6):491-504. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.56367http://ojs.ukw.edu.pl/index.php/johs/article/view/3637 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 755 (23.12.2015).755 Journal of Education, Health and Sport eISSN 2391-8306 7© The Author (s) 2016;This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, PolandOpen Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium,provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License(http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercialuse, distribution and reproduction in any medium, provided the work is properly cited.The authors declare that there is no conflict of interests regarding the publication of this paper.Received: 05.05.2016. Revised 25.05.2016. Accepted: 16.06.2016. Analiza skuteczności terapeutycznej metody MDT McKenzie zastosowanej w leczeniu zespołu zaburzeń strukturalnych w odcinku szyjnym kręgosłupa u 26-letniego mężczyzny – opis przypadku Analysis of therapeutic efficacy of MDT McKenzie method used in the treatment of cervical spine structural disorders in a 26-year-old man - a case report  Piotr Porzych1, Małgorzata Pyskir1, Dorota Ratuszek-Sadowska1, Maciej Dzierżanowski2, Ewa Trela1, Krystyna Nowacka1, Magdalena Hagner‑Derengowska3,4 1.         Katedra i Klinika Rehabilitacji, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu2.         Katedra Fizjoterapii, Zakład Terapii Manualnej, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu3.         Bydgoska Szkoła Wyższa w Bydgoszczy4.         Katedra Neuropsychologii Klinicznej, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu  StreszczenieBóle występujące w obrębie szyi są zjawiskiem powszechnym. Wielogodzinne, wymuszone pozycje statyczne związane z pracą zawodową czy procesem edukacyjnym doprowadzają do przeciążeń kręgosłupa. Konsekwencją przeciążeń są zaburzenia funkcji kręgosłupa oraz zmiany strukturalne tkanek występujących w jego okolicy. Zmianom tym często towarzyszy ból.Złożona biomechanika kręgosłupa oraz różnorodność tkanek funkcjonalnie z nim związanych, stanowi istotny problem diagnostyczny. Metoda McKenzie poprzez opracowany model badania oparty na wywiadzie i badaniu przedmiotowym, pozwala wyodrębnić pacjentów o jednorodnym zaburzeniu narządu ruchu. Na jego podstawie zdiagnozować można mechaniczne źródło pochodzenia objawów oraz określić strukturę, która je generuje.W pracy opisano przypadek 26-letniego mężczyzny z bólem karku i kręczem prawostronnym, który został poddany terapii mechanicznej, poprzedzonej diagnozowaniem mechanicznym, w wyniku którego stwierdzono wystąpienie zespołu zaburzeń strukturalnych. Słowa kluczowe: kręcz karku, terapia mechaniczna, MCS Zebris.  AbstractPain occurring in the neck are common phenomenon. Forced, static and lasting many hours positions associated with work or educational process lead to overloading of the spine. Disorders of the spine function and structural changes of adjoining issue are the consequence of overloading. These changes are often  associated by pain.The highly complicated spine biomechanics and a variety of functionally related tissues are an important diagnostic problem. McKenzie method allows to specify patients with homogeneous musculoskeletal disorder through elaborated diagnostic procedure based on an interview and physical examination. Mechanical cause of symptoms and  structure that generates it can be identify based on it.This paper describes the case of 26-year-old man with neck pain and right torticollis, which has been submited to a mechanical treatment, preceded by a mechanical diagnosis, which concluded the complex of structural disorders. Key words: torticollis, mechanical treatment, MCS Zebris

Original paper expressiOn pattern Of isl-1, ttf-1 and pax5 in OlfactOry neurOblastOma

Olfactory neuroblastoma (ONB) is a rare neoplasm of the sinonasal area with neuroendocrine differentiation. ISL-1, TTF-1 and PAX5 are transcription factors that are frequently upregulated in tumors showing neuroendocrine differentiation. The aim of our study was to evaluate these markers in a group of ONBs. We included 11 ONBs from 4 large university hospitals. Immunohistochemical expression of TTF-1, PAX5 and ISL-1 was evaluated. TTF-1, ISL-1 and PAX5 were expressed in 3/11 cases (27.27%, h-score: 3-45), 7/11 cases (63.64%, h-score: 23-200), and in 3/11 cases (27.77%, h-score 3-85), respectively. The patient with the strongest PAX5 reactivity exhibited an aggressive clinical course with rapid dissemination to the spine and death shortly after the diagnosis. No significant correlation in the expression of PAX5 and TTF-1 (ρ = 0.43; p = 0.18) was observed. ISL-1 is widely expressed in tumors with neuroendocrine differentiation and therefore of limited value in their differential diagnosis. TTF-1 positivity does not exclude the diagnosis of primary ONB, although usually only a small percentage of cells are positive. PAX5 expression is infrequent (27.27%) in ONB; however, if present it can be associated with a very aggressive clinical course

Treatment of Pusher Syndrome in a patient after extensive cerebral infarction caused by cerebral embolism - case report

Porzych Piotr, Ratuszek-Sadowska Dorota, Pyskir Małgorzata, Nowacka Krystyna, Simińska Joanna, Lewandowska Anna, Dzierżanowski Maciej, Hagner‑Derengowska Magdalena. Treatment of Pusher Syndrome in a patient after extensive cerebral infarction caused by cerebral embolism - case report. Journal of Education, Health and Sport. 2017;7(8):583-592. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.888384 http://ojs.ukw.edu.pl/index.php/johs/article/view/4789 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.08.2017. Revised: 10.08.2017. Accepted: 31.08.2017. Leczenie Zespołu Odpychania u pacjenta po rozległym zawale mózgu wywołanym przez zator tętnic mózgowych – opis przypadku Treatment of Pusher Syndrome in a patient after extensive cerebral infarction caused by cerebral embolism - case report Piotr Porzych1, Dorota Ratuszek-Sadowska1, Małgorzata Pyskir1, Krystyna Nowacka1, Joanna Simińska1, Anna Lewandowska1, Maciej Dzierżanowski2, Magdalena Hagner‑Derengowska3 Katedra i Klinika Rehabilitacji, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu Katedra Fizjoterapii, Zakład Terapii Manualnej, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu Katedra Neuropsychologii Klinicznej, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Uniwersytet Mikołaja Kopernika w Toruniu Streszczenie Zespół Odpychania definiowany jako zaburzenie postrzegania orientacji ciała w płaszczyźnie czołowej, obserwowany jest głównie u pacjentów po udarze mózgu w następstwie uszkodzenia prawej lub lewej półkuli. Charakterystycznymi objawami klinicznymi u osób dotkniętych tym zespołem jest pochylanie się w stronę porażoną oraz budowanie masywnego oporu podczas próby biernej korekcji. Konsekwencją takiego zachowania są upadki w kierunku strony porażonej. W pracy przedstawiono przypadek pacjenta, który po rozległym udarze prawej półkuli mózgu został przyjęty do Klinika Rehabilitacji Szpitala Uniwersyteckiego nr 1 im. A Jurasza w Bydgoszczy celem usprawniania. U pacjenta zastosowano metody neurorehabilitacji opartej na koncepcji Bobath. Słowa kluczowe: Zespół Odpychania, zawał mózgu, neurorehabilitacja, NDT Bobath Abstract Pusher Syndrome is defined as a disorder of perception of body orientation in the frontal plane. It is mainly observed in patients after stroke in consequence to damage to the right or left hemisphere of the brain. Characteristic clinical symptoms in people affected by this syndrome are leaning towards the paralyzed side of the body and building massive resistance during passive correction. The consequence of such behavior are falls in the direction of the affected side. The paper presents the case of a patient who, after extensive right hemisphere cerebral hemorrhage, was admitted to the Chair and Department of Rehabilitation Medicine of the Dr Antoni Jurasz University Hospital No.1 in Bydgoszcz to improve. During treatment the patient was used the neurorehabilitation based on the Bobath concept. Key words: Pusher Syndrome, brain infarction, neurorehabilitation, NDT Bobat