Research and Review of EudragitTM Polymers in the Development of pH-Targeted Pharmaceutical Delivery

Undergraduate Basi

Research and Review of Polymethyl-Methacrylate Copolymers in the Development of Enhanced Pharmaceutical Delivery Systems

The following thesis shall primarily explore the current research regarding the implementation of modifiable microscopic and nanoscopic polymer particles as novel pharmaceutical delivery systems. Polymethacrylate-based copolymers, such as EudragitTM, are sensitive to alterations in pH levels, becoming increasingly more soluble in response to an increase in pH. The selective solubility and modifiable nature of these polymers allows for greater flexibility of treatment options for patients (Patra et al., 2017). The wide range of functionality of polymethacrylate (PMA) may provide solutions to challenges relating to the current treatment and therapy of certain conditions. Research indicates that PMA based micro- and nanoparticle polymer excipients may preserve oral insulin in the treatment of diabetes, act as superior carriers for the therapy of colonic cancer, and target colonic regions in patients for stable, sustained release of medication in the treatment of IBD and its symptoms (Bettencourt & Almeida, 2015). Additionally, an overview of the research performed at Liberty University’s Department of Biology and Chemistry in this field under the direction of Michael Korn, Ph. D will be reviewed. The research focused on the experimental activities relating to the synthesis and analysis of the basic characteristics of EudragitS100 polymer microspheres. Specifically, the constructed microdroplets were visualized via fluorescent microscopy in an attempt to develop microscopic polymeric particles that could be compared to those being developed in industry

Structural performance of two aerobrake hexagonal heat shield panel concepts

Structural sizing and performance are presented for two structural concepts for an aerobrake hexagonal heat shield panel. One concept features a sandwich construction with an aluminum honeycomb core and thin quasi-isotropic graphite-epoxy face sheets. The other concept features a skin-rib isogrid construction with thin quasi-isotropic graphite-epoxy skins and graphite-epoxy ribs oriented at 0, +60, and -60 degs along the panel. Linear static, linear bifurcation buckling, and nonlinear static analyses were performed to compare the structural performance of the two panel concepts and assess their feasibility for a lunar transfer vehicle aerobrake application

Student Engagement: The Effects of Goals, Personality, Relations, and Society

Undergraduate Applie

Family Commuication Pattern and Power Theory

Abstract This paper is a review of the Family Communication Patterns Theory (FCPT) and Family Communication Power Theory and the research conducted from the marital, family, and interpersonal communication perspective of the two theories. The review of literature determined the negative and positive effects of events that can, in turn, have a negative or positive reaction about the family communication pattern and power theory. Keywords: Family Communication, Family Communication Pattern, Family Communication Patterns Theory, Communication, Communication Conformity, Communicatio

A Survey of Accounting Case Studies

The following document contains work done over the span of a year under the direction of Dr. Victoria Dickinson at the University of Mississippi in the Honors Accy 420 class. For the thesis requrement in accordance with the standards set by the Patterson School of Accountancy and the Sally McDonnell Barksdale Honors College, I was able to complete a set of case studies pertaining to accounting. The purpose of this research program is to help equip students pursuing a career in the accounting field through a variety of accounting topics. Some cases focus on accounting principles in accordance with GAAP, while others focus on specific events that have occurred in the accounting field

Credit Rating Agency Review Board: The Challenges and Implications of Implementing the Franken-Wicker Amendment to Dodd-Frank

The purpose of this paper is to analyze, critically review, and determine whether a hypothetical credit rating agency board, as suggested in the Franken-Wicker Amendment to the Dodd-Frank Act, is a viable option for combating the conflict of interest problem between credit rating agencies and issuers. Research methodology includes a careful review of various ways to structure the board and the potential unintended consequences of doing so. The Author uses original research hand-collected from video of the Credit Ratings Roundtable conducted in Washington D.C. on May 14, 2013. The Credit Ratings Roundtable brought together experts from the credit rating industry and government to discuss the viability of a credit rating agency board. After reviewing the research, the paper concludes, while the credit rating agency board will be difficult to implement and may have various negative unintended consequences, it is currently the best option available to break the conflict of interest

Remote Analysis Capabilities of Digitally Rendered Models of Human Remains: Obtaining Osteometric Data & Assessing Pathology and Taphonomic Alteration - Using Non-Human Animal Remains as an Analogue

Computed tomography (CT), photogrammetry, and laser surface scanning technologies have enabled remote, noninvasive, and non-destructive analysis of skeletal human remains in various contexts. Such technologies have found applications in the disciplines of osteoarchaeology, forensic anthropology, the medical sciences, and other related fields of inquiry. This presentation will discuss the accuracy and reliability of osteometric data obtained from digitally rendered models, as well as the clarity and level of detail attained. Such qualifying standards are essential if practitioners are to reliably assess pathology and taphonomic alteration to the specimens from which the scans are modeled. The suitability of each of the aforementioned technologies is discussed with regard to their intended use. A photogrammetry scan of non-human animal remains was obtained for illustrative purposes

Off with His Head: The King Can Do No Wrong, Hurricane Katrina, and the Mississippi River Gulf Outlet

Congress passed the Federal Tort Claims Act in 1946 to provide a legal remedy to citizens for torts committed by the Federal Government. Prior to the act, United States citizens were mostly prohibited from filing suits against the government for torts committed by government employees. However, Congress when passing the act realized that some government actions are the result of considered policy judgment for what is in the best interest of the citizenry as a whole. In order to prevent the government from being sued for such actions, Congress included what is referred to as the Discretionary Function Exception. If a government employee’s action falls within the parameters of the Discretionary Function Exception the government is immune from tort liability. This Article argues that courts have interpreted the Discretionary Function too broadly such that it now excuses the government from egregious unjustifiable harms to the American public. The Article explores this topic using a recent example in which the Fifth Circuit Court of Appeals, in a confused opinion, denied relief to victims of Hurricane Katrina. Even though the Army Corps of Engineers—who is responsible for a navigational canal found to be the cause of multiple levee breaches—admitted wrongdoing, the Fifth Circuit used the broad application of the Discretionary Function Exception to deny liability for the government. After reviewing the jurisprudential history of the Federal Tort Claims Act, the Article argues that a doctrinal application of the Discretionary Function Exception should find that the government is not immune from liability. Finally, the Article reviews the purposes and policy justifications for tort law and concludes that the only just result in the Hurricane Katrina case is a finding of liability

Optimization of the material selection process for cryogenic composite overwrapped pressure vessels

The objective of this research was to develop a test methodology for the evaluation of materials for possible use in cryogenic composite overwrapped pressure vessels (COPVs). This paper investigates various micromechanical and macromechanical techniques to test the interaction between fibers and resins. Uniaxial tension testing was performed at ambient and cryogenic temperatures on neat resin samples, straight-sided composite specimens, and NOL ring specimens. COPVs were constructed and burst tested to provide a performance comparison. Results show resins suitable for use at cryogenic conditions display a LN2 temperature elongation to failure greater than 2% and an ambient temperature elastic modulus less than 35 MPa. NOL rings were determined to be the preferred composite test method rather than straight-sided specimens. Mechanical performance of the NOL rings compares well with actual COPV performance