Insurance Coverage in a Climate Changed Canada: How Can Canada Pay for Loss and Damage from Anthropogenic Climate Change?

This article looks at the impact of anthropogenic climate change and its associated costs in the Canadian context. It begins by outlining how climate change is predicted to alter the Canadian climate before evaluating how this will affect the insurance industry. It determines that insurers’ response to the unpredictable risks and high costs associated with climate change will lead to significant gaps in coverage. How litigation of major carbon polluters could help cover some of the costs associated with climate change by holding polluters accountable is considered. State-led climate litigation can overcome some of the litigation obstacles identified and it may be preferable to civil litigation. The current state of civil and state-led litigation will be inadequate to address the mounting costs associated with climate change. Thus, the article considers the use of legislation to assist state-led litigation against major carbon polluters, which would be modeled after the tobacco legislation first used in British Columbia. The article contemplates how these funds could be disbursed into disaster relief and no-fault insurance schemes to compensate for climate loss and damage, as well as briefly discussing the international concerns relevant to these domestic issues. Ultimately, it is determined that there are viable combinations of legislation, litigation, taxation, compensation, mitigation, adaptation, and insurance that can better prepare Canada for managing the high costs associated with anthropogenic climate change

The Mismatch of the Language of Textbooks and Language of ESL Students in Content Classrooms

Debate concerning bilingual education effectiveness may focus around the definition of academic language. Two aspects of such-vocabulary and grammar-were examined in 4th and 8th grade textbooks. Results showed substantial increases in the number of abstract words and complex sentences, suggesting more daunting language demands for older non-English-speaking students

Literacy, Teens, Refugees, and Soccer

This study examined the literacy development of teenage refugee boys in a one-month intensive summer literacy camp. The study intervention sought to abate literacy regression among language minority students in a suburban southern US city by combining physical training and promotion of literacy culture. Students experienced an intensive schedule of athletics and reading/writing workshops. Data were collected regarding student writing, reading proficiency, and dispositions toward literacy practices. Outcomes included increased expressed student enjoyment expressed for both reading and writing, especially for the experience of older students reading to younger peers. In addition, data indicated that summer literacy regression was largely avoided. However, reading proficiency level assessments foreshadow obstacles for students in achieving timely high school graduation. Finally, means used by mainstream teachers of assessing the literacy of refugee students, especially compared to assessments of proficient English-speaking students, are critiqued.Cette étude examine le développement de la littératie de jeunes adolescents réfugiés lors d’un camp d’été intensif d’alphabétisation d’une durée d’un mois. L’intervention examinée visait à freiner la régression de la littératie chez les étudiants de minorités linguistiques d’une banlieue du sud des États-Unis, en combinant l’entraînement physique et la promotion de la culture écrite. Les étudiants ont suivi  un horaire intensif d’activités athlétiques et d’ateliers de lecture et d’écriture. Les données recueillies se rapportaient à l’écriture, les compétences de lectures, et à la disposition aux pratiques de la littératie des étudiants. Les résultats incluent l’augmentation du plaisir de la lecture et de l’écriture exprimé par les étudiants, en particulier au sujet de l’expérience qu’ont faite les étudiants plus vieux de lire aux plus jeunes. De plus, les données indiquent que la régression de littératie propre aux vacances estivales avait été évitée. Néanmoins, les évaluations des compétences de lecture laisser présager que les étudiants rencontreront des obstacles dans l’obtention de leur diplôme d’études secondaires dans les temps prévus. Enfin, on y fait la critique des moyens que les enseignants réguliers emploient pour évaluer la littératie des étudiants réfugiés, surtout en comparaison avec l’évaluation des étudiants de langue anglaise

Improving the Preparation of Teachers Wishing to Work in Two-Way Bilingual Education Programs: Listening to the Practitioners

Two-way bilingual school principals were interviewed to find out their views on staffing. Finding candidates proficient in Spanish to provide content area instruction in this language was their greatest challenge. They suggested that the university offer content courses taught in Spanish and courses focusing on the mechanics of the language

Drug elucidation: invertebrate genetics sheds new light on the molecular targets of CNS drugs

Many important drugs approved to treat common human diseases were discovered by serendipity, without a firm understanding of their modes of action. As a result, the side effects and interactions of these medications are often unpredictable, and there is limited guidance for improving the design of next-generation drugs. Here, we review the innovative use of simple model organisms, especially Caenorhabditis elegans, to gain fresh insights into the complex biological effects of approved CNS medications. Whereas drug discovery involves the identification of new drug targets and lead compounds/biologics, and drug development spans preclinical testing to FDA approval, drug elucidation refers to the process of understanding the mechanisms of action of marketed drugs by studying their novel effects in model organisms. Drug elucidation studies have revealed new pathways affected by antipsychotic drugs, e.g., the insulin signaling pathway, a trace amine receptor and a nicotinic acetylcholine receptor. Similarly, novel targets of antidepressant drugs and lithium have been identified in C. elegans, including lipid-binding/transport proteins and the SGK-1 signaling pathway, respectively. Elucidation of the mode of action of anesthetic agents has shown that anesthesia can involve mitochondrial targets, leak currents, and gap junctions. The general approach reviewed in this article has advanced our knowledge about important drugs for CNS disorders and can guide future drug discovery efforts

Antidepressant mechanisms of ketamine: a review of actions with relevance to treatment-resistance and neuroprogression

Concurrent with recent insights into the neuroprogressive nature of depression, ketamine shows promise in interfering with several neuroprogressive factors, and has been suggested to reverse neuropathological patterns seen in depression. These insights come at a time of great need for novel approaches, as prevalence is rising and current treatment options remain inadequate for a large number of people. The rapidly growing literature on ketamine’s antidepressant potential has yielded multiple proposed mechanisms of action, many of which have implications for recently elucidated aspects of depressive pathology. This review aims to provide the reader with an understanding of neuroprogressive aspects of depressive pathology and how ketamine is suggested to act on it. Literature was identified through PubMed and Google Scholar, and the reference lists of retrieved articles. When reviewing the evidence of depressive pathology, a picture emerges of four elements interacting with each other to facilitate progressive worsening, namely stress, inflammation, neurotoxicity and neurodegeneration. Ketamine acts on all of these levels of pathology, with rapid and potent reductions of depressive symptoms. Converging evidence suggests that ketamine works to increase stress resilience and reverse stress-induced dysfunction, modulate systemic inflammation and neuroinflammation, attenuate neurotoxic processes and glial dysfunction, and facilitate synaptogenesis rather than neurodegeneration. Still, much remains to be revealed about ketamine’s antidepressant mechanisms of action, and research is lacking on the durability of effect. The findings discussed herein calls for more longitudinal approaches when determining efficacy and its relation to neuroprogressive factors, and could provide relevant considerations for clinical implementation.publishedVersio

Simultaneous Measurement of the BOLD Effect and Metabolic Changes in Response to Visual Stimulation Using the MEGA-PRESS Sequence at 3 T

The blood oxygen level dependent (BOLD) effect that provides the contrast in functional magnetic resonance imaging (fMRI) has been demonstrated to affect the linewidth of spectral peaks as measured with magnetic resonance spectroscopy (MRS) and through this, may be used as an indirect measure of cerebral blood flow related to neural activity. By acquiring MR-spectra interleaved with frames without water suppression, it may be possible to image the BOLD effect and associated metabolic changes simultaneously through changes in the linewidth of the unsuppressed water peak. The purpose of this study was to implement this approach with the MEGA-PRESS sequence, widely considered to be the standard sequence for quantitative measurement of GABA at field strengths of 3 T and lower, to observe how changes in both glutamate (measured as Glx) and GABA levels may relate to changes due to the BOLD effect. MR-spectra and fMRI were acquired from the occipital cortex (OCC) of 20 healthy participants whilst undergoing intrascanner visual stimulation in the form of a red and black radial checkerboard, alternating at 8 Hz, in 90 s blocks comprising 30 s of visual stimulation followed by 60 s of rest. Results show very strong agreement between the changes in the linewidth of the unsuppressed water signal and the canonical haemodynamic response function as well as a strong, negative, but not statistically significant, correlation with the Glx signal as measured from the OFF spectra in MEGA-PRESS pairs. Findings from this experiment suggest that the unsuppressed water signal provides a reliable measure of the BOLD effect and that correlations with associated changes in GABA and Glx levels may also be measured. However, discrepancies between metabolite levels as measured from the difference and OFF spectra raise questions regarding the reliability of the respective methods.publishedVersio

GABA, glutamatergic dynamics and BOLD contrast assessed concurrently using functional MRS during a cognitive task

A recurring issue in functional neuroimaging is how to link task-driven haemodynamic blood oxygen level dependent functional MRI (BOLD-fMRI) responses to underlying neurochemistry at the synaptic level. Glutamate and γ-aminobutyric acid (GABA), the major excitatory and inhibitory neurotransmitters respectively, are typically measured with MRS sequences separately from fMRI, in the absence of a task. The present study aims to resolve this disconnect, developing acquisition and processing techniques to simultaneously assess GABA, glutamate and glutamine (Glx) and BOLD in relation to a cognitive task, at 3 T. Healthy subjects (N = 81) performed a cognitive task (Eriksen flanker), which was presented visually in a task-OFF, task-ON block design, with individual event onset timing jittered with respect to the MRS readout. fMRS data were acquired from the medial anterior cingulate cortex during task performance, using an adapted MEGA-PRESS implementation incorporating unsuppressed water-reference signals at a regular interval. These allowed for continuous assessment of BOLD activation, through T2*-related changes in water linewidth. BOLD-fMRI data were additionally acquired. A novel linear model was used to extract modelled metabolite spectra associated with discrete functional stimuli, building on well established processing and quantification tools. Behavioural outcomes from the flanker task, and activation patterns from the BOLD-fMRI sequence, were as expected from the literature. BOLD response assessed through fMRS showed a significant correlation with fMRI, specific to the fMRS-targeted region of interest; fMRS-assessed BOLD additionally correlated with lengthening of response time in the incongruent flanker condition. While no significant task-related changes were observed for GABA+, a significant increase in measured Glx levels (~8.8%) was found between task-OFF and task-ON periods. These findings verify the efficacy of our protocol and analysis pipelines for the simultaneous assessment of metabolite dynamics and BOLD. As well as establishing a robust basis for further work using these techniques, we also identify a number of clear directions for further refinement in future studies.publishedVersio