Notes on Stein-Sahi representations and some problems of non L2L^2 harmonic analysis

We discuss one natural class of kernels on pseudo-Riemannian symmetric spaces.Comment: 40p

Spatially organizing future genders: an artistic intervention in the creation of a hir-toilet

Toilets, a neglected facility in the study of human relations at work and beyond, have become increasingly important in discussions about future experiences of gender diversity. To further investigate the spatial production of gender and its potential expressions, we transformed a unisex single-occupancy toilet at Uppsala University into an all-gender or ‘hir-toilet’.1 With the aim to disrupt and expose the dominant spatial organization of the two binary genders, we inaugurated the hir-toilet with the help of a performance artist. We describe and analyse internal and external responses thereto, using Lefebvre’s work on dialectics and space. Focusing on how space is variously lived, conceived and perceived, our analysis questions the very rationale of gender categorizations. The results contribute to a renewed critique of binary thinking in the organization of workplaces by extending our understanding of how space and human relations mutually constitute each other

Structure of a highly conserved domain of rock1 required for shroom-mediated regulation of cell morphology

Rho-associated coiled coil containing protein kinase (Rho-kinase or Rock) is a well-defined determinant of actin organization and dynamics in most animal cells characterized to date. One of the primary effectors of Rock is non-muscle myosin II. Activation of Rock results in increased contractility of myosin II and subsequent changes in actin architecture and cell morphology. The regulation of Rock is thought to occur via autoinhibition of the kinase domain via intramolecular interactions between the N-terminus and the C-terminus of the kinase. This autoinhibited state can be relieved via proteolytic cleavage, binding of lipids to a Pleckstrin Homology domain near the C-terminus, or binding of GTP-bound RhoA to the central coiled-coil region of Rock. Recent work has identified the Shroom family of proteins as an additional regulator of Rock either at the level of cellular distribution or catalytic activity or both. The Shroom-Rock complex is conserved in most animals and is essential for the formation of the neural tube, eye, and gut in vertebrates. To address the mechanism by which Shroom and Rock interact, we have solved the structure of the coiled-coil region of Rock that binds to Shroom proteins. Consistent with other observations, the Shroom binding domain is a parallel coiled-coil dimer. Using biochemical approaches, we have identified a large patch of residues that contribute to Shrm binding. Their orientation suggests that there may be two independent Shrm binding sites on opposing faces of the coiled-coil region of Rock. Finally, we show that the binding surface is essential for Rock colocalization with Shroom and for Shroom-mediated changes in cell morphology. © 2013 Mohan et al

Dominância fiscal : uma investigação empírica sobre o caso brasileiro no período de 2003 a 2014

A estabilização econômica dos anos de 1990 e a adoção do tripé econômico, a partir de 1999, marcam o fim de um capítulo delicado da história brasileira; a partir de então, era necessária a existência de certa sintonia de políticas monetária e fiscal para a manutenção do controle dos diversos indicadores econômicos. Contudo, com essa reciprocidade na política econômica, são incitadas discussões sobre a orientação do governo na hora de definir suas prioridades nesse campo: as variáveis fiscais são priorizadas e, por conseguinte, determinadas, forçando as monetárias a se ajustarem – ou o contrário? A resposta para esse questionamento leva à discussão sobre a dominância fiscal. Assim, esse trabalho visa verificar empiricamente, usando das modelagens econométricas VAR e estudo de eventos, se há dominância fiscal ou monetária na economia brasileira e se a eficácia da política monetária mudou na transição do governo Lula para o governo Dilma. O resultado foi inconclusivo para o governo Lula e indicou dominância fiscal no governo Dilma. Ainda verificou-se não haver modificação na eficácia da política monetária.Economic stabilization, in the 1990s, and utilization of an economic tripod, after 1999, represents the end of a delicate chapter in Brazilian history. Ever since, it was necessary the existence of a certain agreement between monetary and fiscal politic, in order to maintain under control a variety of economic indicators. However, this reciprocity (in economic politic) starts discussions about the real government orientations when it comes to define its priority on this subject: are the fiscal variables priorized, and then, determined, forcing monetary variables to adjust themselves, or the opposite? The answer to these questions emerge from the fiscal dominance discussion. This paper intends to empiric verify, using econometric modeling VAR and event study, if there is fiscal dominance or monetary in Brazilian economy and whether the effectiveness of monetary politic has changed in the transition from Lula's government to the Dilma government. The result was inconclusive for the Lula government and indicated fiscal dominance in the Dilma government. There was still no change in the efficiency of the monetary politic.CAPE

Properties of composites incorporating cellulosic fibers

Nowadays, with the understanding of the importance of the green building concept, there is a constantly increasing demand for ecological construction materials. The application of raw materials from renewable sources such as wood, plants and waste to building materials preparing has gained a significant interest in this research area. With the consideration of environmental consciousness, natural fibers are biodegradable so as they can alleviate the problem of massive solid waste produced and relief the pressure of landfills, they are used for replacing other non-degradable materials for product development. In this experimental work, wood pulp and recycled waste paper fibers in addition 0.2%, 0.3% and 0.5% were used. The fiber cement composites were subjected to a characterization of their composition including the assessment of a complex set of basic physical and mechanical properties after 7 and 28 days of hardening. Experimental results show that application of small amount of cellulosic fibers lead to a reduction of density up to 6% when compared with the reference composite. However, cement composites based on wood pulp showed better mechanical properties such as compressive and flexural strength in comparison with cement composites with recycled waste paper fibers

Sposób wykorzystania poliuretanu po zakończeniu jego cyklu żywotności

Wykorzystanie surowców wtórnych stanowi bardzo istotny element w zakresie ochrony środowiska i przy zapewnieniu zrównoważonego rozwoju. Naszym celem jest stałe badanie ukrytego potencjału wykorzystania wytwarzanych odpadów. Oczywiście, zadanie polega na stałej optymalizacji sortowania surowców wtórnych i surowców mających na celu ich lepsze wykorzystanie, a ostatecznie na ich finansową wycenę. To jest nasz sposób reagowania na rosnącą potrzebę utylizacji odpadów i surowców odpadowych przed ich składowaniem, na które wpływa przede wszystkim określone, obowiązujące prawo dotyczące środowiska, a po drugie, ten krok jest częścią celów środowiskowych naszego społeczeństwa. Obecnie produkcja poliuretanów wynosi około 7% całkowitego wolumenu tworzyw sztucznych produkowanych w Europie. Republika Czeska ma roczną produkcję ok. 10 000 ton odpadów sztywnej pianki poliuretanowej. Są to głównie odpady wielkogabarytowe, które w zasadzie nie podlegają efektywnemu składowaniu. Powyżej podana masa/ilość odpadów poliuretanowych była inspiracją do zapoczątkowania badań podstawowych w zakresie wykorzystania recyklingu pianki poliuretanowej pod koniec cyklu żywotności produktu w segmencie materiałów budowlanych. W artykule przedstawiono część wyników projektu badawczego pod nazwą „Badanie topografii powierzchni i struktury materiałów zdegradowanych przez sole i proponowane środki/zamierzenia (technologia odnawiania) za pomocą zapraw opartych na piankach poliuretanowych w końcu ich cyklu życia”. Są to: 1. eksperymentalne receptury zapraw renowacyjnych pochodzących z recyklingu pianki poliuretanowej o masie właściwej od 30 do 40 kg•m−3 i maksymalnej wielkości ziarna PUR 2 mm jako wypełniacza w zaprawach odnawialnych; 2. właściwości fizyczne i mechaniczne doświadczalnych mieszanek (masa właściwa utwardzonej zaprawy, wytrzymałość, czas rozsmarowania, przyczepność/stopień przylegania, kapilarna absorpcja wody, zawartość porów powietrznych); 3. opis stosowania odnawialnej zaprawy poliuretanowej na ścianie

Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

International audienceThe KRAS gene is the most common locus for somatic gain-of-function mutations in human cancer. Germline KRAS mutations were shown recently to be associated with developmental disorders, including Noonan syndrome (NS), cardio-facio-cutaneous syndrome (CFCS), and Costello syndrome (CS). The molecular basis of this broad phenotypic variability has remained elusive, so far. Here, we comprehensively analyzed the biochemical and structural features of ten germline KRAS mutations using physical and cellular biochemistry. According to their distinct biochemical and structural alterations, the mutants can be grouped into five distinct classes that markedly differ from RAS oncoproteins. Investigated functional alterations comprise the enhancement of intrinsic and guanine nucleotide exchange factor (GEF) catalyzed nucleotide exchange, which is alternatively accompanied by an impaired GTPase-activating protein (GAP) stimulated GTP hydrolysis, an overall loss of functional properties, and a deficiency in effector interaction. In conclusion, our data underscore the important role of RAS in the pathogenesis of the group of related disorders including NS (OMIM 163950), CFCS (OMIM 115150), and CS (OMIM 218040) and provide clues to the high phenotypic variability of patients with germline KRAS mutations