Effect of Mesotrione and Nicosulfuron Mixtures With or Without Adjuvants

ABSTRACT: In Field experiments, a logarithmic sprayer was used to screen the efficacy of 28.5% mixture of nicosulfuron and mesotrione, and the herbicides applied separately. Three adjuvants were also used to assess how they affected the potency of the mixture. The objectives were to test whether a mixture was enhancing or detracting the effect relative to ADM (Additive Dose Model). The test plants were canola and barley. The 28.5% nicosulfuron mixture was acting antagonistic, irrespective of plant species. The antagonistic effect of the nicosulfuron mixture decreased the more developed the plants became; for barley, it almost disappeared 40 days after treatment. For both canola and barley, one adjuvant stood out as being highly effective in decreasing ED50 of the mixture. Antagonism was not alarmingly high, which is found for many herbicides. Results are discussed in relation to the practice of testing mixtures in the literature and the requirements for getting mixture patents

Aspherical Explosion Models for SN 1998bw/GRB 980425

The recent discovery of the unusual supernova SN1998bw and its apparent correlation with the gamma-ray burst GRB 980425 has raised new issues concerning both the GRB and supernovae. Although the spectra resemble those of TypeIc supernovae, there are distinct differences at early times and SN1998bw appeared to be unusually bright and red at maximum light. The apparent expansion velocities inferred by the Doppler shift of (unidentified) absorption features appeared to be high, making SN1998bw a possible candidate for a "hypernova" with explosion energies between 20 and 50E51 erg and ejecta masses in excess of 6 - 15 M_o. Based on light curve calculations for aspherical explosions and guided by the polarization observations of "normal" SNIc and related events, we present an alternative picture that allows SN1998bw to have an explosion energy and ejecta mass consistent with core collapse supernovae (although at the 'bright' end). We show that the LC of SN1998bw can be understood as result of an aspherical explosion along the rotational axis of a basically spherical, non-degenerate C/O core of massive star with an explosion energy of 2foe and a total ejecta mass of 2 M_o if it is seen from high inclinations with respect to the plane of symmetry. In this model, the high expansion velocities are a direct consequence of an aspherical explosion which, in turn, produces oblate iso-density contours. It suggests that the fundamental core-collapse explosion process itself is strongly asymmetric.Comment: 12 pages, 8 figures, latex, aas2pp4.sty, submitted to Ap

Trade in the Shadow of Power : Japanese Industrial Exports in the Interwar years

During the interwar years, Japanese industrialisation accelerated alongside the expansion of industrial exports to regional markets. Trade blocs in the interwar years were used as an instrument of imperial power to foster exports and as a substitute for productivity to encourage industrial production. The historiography on Japanese industrialisation in the interwar years describes heavy industries' interests in obtaining access to wider markets to increase economies of scale and reduce unit costs. However, this literature provides no quantitative evidence that proves the success of those mechanisms in expanding exports. In this paper we scrutinise how Japan—a relatively poor country—used colonial as well as informal power interventions to expand regional markets for its exports, especially for the most intensive human capital sector of the industrializing economy

Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib

Heat shock protein 90 (Hsp90) is a promising target for anti-tumor therapy. We previously reported the anti-tumor activity of a novel Hsp90 inhibitor, KW-2478, in multiple myeloma (MM) as a single agent. In this study, we examined the combinational effect of KW-2478 and bortezomib, a proteasome inhibitor, in vitro and in vivo. In vitro, KW-2478 enhanced bortezomib-induced cell growth inhibition, both in MM cell lines and primary patient MM cells. The combination of KW-2478 and bortezomib also induced caspase activation in MM cell lines. Interestingly, the combination synergistically enhanced the expression of Hsp70B, a homolog of Hsp70, in human MM cells and peripheral blood mononuclear cells, indicating Hsp70B could be a surrogate biomarker for the combination of Hsp90 and proteasome inhibitors. In vivo, the combination of KW-2478 with bortezomib showed synergistic anti-tumor activity without significant body weight loss in a subcutaneously inoculated human myeloma model. Furthermore, the combination also showed synergistic reduction of tumor burden in bone marrow in an orthotopic myeloma model. Our results strongly suggest that combination of KW-2478 with bortezomib could exhibit enhanced anti-tumor activity against human myeloma

Patterns and Risk Factors of Helminthiasis and Anemia in a Rural and a Peri-urban Community in Zanzibar, in the Context of Helminth Control Programs

In many parts of the developing world, parasitic worms and anemia are of considerable public health and economic importance. We studied the patterns and risk factors of parasitic worm infections in a rural and a peri-urban community on Zanzibar Island, Tanzania, in the context of national deworming programs. We invited 658 individuals aged between 5 and 100 years and examined their stool and urine for the presence of parasitic worm eggs. Additionally, we obtained a finger-prick blood sample to estimate the level of anemia and to assess for specific immune reactions against parasitic worm infections. We found that, despite large-scale deworming efforts in Zanzibar over the past 15 years, three-quarter of the rural participants and half of the peri-urban residents were infected with parasitic worms. Every second participant was anemic. Risk factors for a parasitic worm infection were age, sex, consumption of raw vegetables or salad, recent travel history, and socio-economic status. For a sustainable control of parasitic worm infections and prevention of anemia, access to safe and efficacious drugs, complemented with health education and improvements in water supply and adequate sanitation are necessary