6 research outputs found

    Physico-chemical characterization and synthesis of neuronally active alpha-conotoxins

    No full text
    The high speciFIcity of alpha-conotoxins for different neuronal nicotinic acetylcholine receptors makes them important probes for dissecting receptor subtype selectivity. New sequences continue to expand the diversity and utility of the pool of available alpha-conotoxins. Their identification and characterization depend on a suite of techniques with increasing emphasis on mass spectrometry and microscale chromatography, which have benefited from recent advances in resolution and capability. Rigorous physicochemical analysis together with synthetic peptide chemistry is a prerequisite for detailed conformational analysis and to provide sufficient quantities of alpha-conotoxins for activity assessment and structure-activity relationship studies

    Timing of major fracture care in polytrauma patients – An update on principles, parameters and strategies for 2020

    No full text

    References

    No full text
    corecore