Economical Analysis of Financial Supports for Large-Scale Photovoltaic PV plants in Eastern Europeen Union Countries

Today, photovoltaic (PV) attracts considerable interest among renewable energy sources (RES), because of its potential to significantly contribute to the future of clean energies. However, PV development is strongly related to the support policies introduced by national governments. The modification or fading out of such support schemes can strongly influence the development of the PV market in any given country. Although the PV market in European developing countries is still quite small, it has been growing rapidly in recent years. Until 2006, the installation of small off-grid PV plants prevailed in eastern EU countries. Starting from 2008, large-scale on-grid PV plants have been put into effect. Today on-grid installations constitute more than 95% of the total installed PV plants. The large increase of PV market in the last two years is a consequence of the enormous development of PV sector in the Czech market, stimulated by effective support mechanisms. Other developing member states, such as Slovakia and Bulgaria, have adequate PV support schemes including, in particular, effective Feed-in Tariff (FIT) systems. Other support mechanisms are tradable green certificates (TGCs), capital subsidies, tax credit and net metering. In this paper, after a brief review of national support policies in PV technology in the considered EU developing countries, the authors perform an economic analysis of the main support mechanisms that are implemented in these countries. The comparative analysis is based on the calculation of the cash flow, the Net Present Value (NPV) and the Internal Rate of Return (IRR) indices. The analysis shows that in some situations, support policies can be inconvenient for the owner of the PV system and that, in many cases, the differences between the implementation of the same support policy in different countries, can give rise to significantly different results. The comparative analysis carried out in this work could help: to evaluate the impact of the PV energy measures in eastern EU member states; to gain an insight into green energy companies by identifying potential PV markets and investigating the policy landscape across eastern EU countries

Human activity modeling and Barabasi's queueing systems

It has been shown by A.-L. Barabasi that the priority based scheduling rules in single stage queuing systems (QS) generates fat tail behavior for the tasks waiting time distributions (WTD). Such fat tails are due to the waiting times of very low priority tasks which stay unserved almost forever as the task priority indices (PI) are "frozen in time" (i.e. a task priority is assigned once for all to each incoming task). Relaxing the "frozen in time" assumption, this paper studies the new dynamic behavior expected when the priority of each incoming tasks is time-dependent (i.e. "aging mechanisms" are allowed). For two class of models, namely 1) a population type model with an age structure and 2) a QS with deadlines assigned to the incoming tasks which is operated under the "earliest-deadline-first" policy, we are able to analytically extract some relevant characteristics of the the tasks waiting time distribution. As the aging mechanism ultimately assign high priority to any long waiting tasks, fat tails in the WTD cannot find their origin in the scheduling rule alone thus showing a fundamental difference between the present and the A.-L. Barabasi's class of models.Comment: 16 pages, 2 figure

Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function

Mitochondrial dysfunction and oxidative stress have been implicated in the etiology of Parkinson's disease. Therefore, pathways controlling mitochondrial activity rapidly emerge as potential therapeutic targets. Here, we explore the neuronal response to prolonged overexpression of peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α), a transcriptional regulator of mitochondrial function, both in vitro and in vivo. In neuronal primary cultures from the ventral midbrain, PGC-1α induces mitochondrial biogenesis and increases basal respiration. Over time, we observe an increasing proportion of the oxygen consumed by neurons which are dedicated to adenosine triphosphate production. In parallel to enhanced oxidative phosphorylation, PGC-1α progressively leads to a decrease in mitochondrial polarization. In the adult rat nigrostriatal system, adeno-associated virus (AAV)-mediated overexpression of PGC-1α induces the selective loss of dopaminergic markers and increases dopamine (DA) catabolism, leading to a reduction in striatal DA content. In addition, PGC-1α prevents the labeling of nigral neurons following striatal injection of the fluorogold retrograde tracer. When PGC-1α is expressed at higher levels following intranigral AAV injection, it leads to overt degeneration of dopaminergic neurons. Finally, PGC-1α overexpression does not prevent nigrostriatal degeneration in pathologic conditions induced by α-synuclein overexpression. Overall, we find that lasting overexpression of PGC-1α leads to major alterations in the metabolic activity of neuronal cells which dramatically impair dopaminergic function in vivo. These results highlight the central role of PGC-1α in the function and survival of dopaminergic neurons and the critical need for maintaining physiological levels of PGC-1α activit

The feed-in tariff in the UK : a case study focus on domestic photovoltaic systems

This paper explores the photovoltaic (PV) industry in the United Kingdom (UK) as experienced by those who are working with it directly and with consideration of current standards, module efficiencies and future environmental trends. The government's consultation on the comprehensive review for solar PV tariffs, proposes a reduction of the generation tariff for PV installations in the UK of more than 50%. The introduction of the Feed-In Tariffs scheme (FITs) has rapidly increased deployment of PV technologies at small scale since its introduction in April 2010. The central principle of FIT policies is to offer guaranteed prices for fixed periods to enable greater number of investors. A financial analysis was performed on two real-life installations in Cornwall, UK to determine the impact of proposed cuts to the FIT will make to a typical domestic PV system under 4 kW. The results show that a healthy Return on Investment (ROI) can still be made but that future installations should focus on off-setting electricity required from the national grid as a long term push for true sustainability rather than subsidised schemes. The profitability of future installations will have to be featured within in-service and end-of-service considerations such as the feed-in tariff, module efficiencies and the implications of costs associated with end-of-life disposal

Exogenous LRRK2G2019S induces parkinsonian-like pathology in a nonhuman primate

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease among the elderly. To understand pathogenesis and to test therapies, animal models that faithfully reproduce key pathological PD hallmarks are needed. As a prelude to developing a model of PD, we tested the tropism, efficacy, biodistribution, and transcriptional impact of canine adenovirus type 2 (CAV-2) vectors in the brain of Microcebus murinus, a nonhuman primate that naturally develops neurodegenerative lesions. We show that introducing helper-dependent (HD) CAV-2 vectors results in long-term, neuron-specific expression at the injection site and in afferent nuclei. Although HD CAV-2 vector injection induced a modest transcriptional response, no significant adaptive immune response was generated. We then generated and tested HD CAV-2 vectors expressing LRRK2 (leucine-rich repeat kinase 2) and LRRK2 carrying a G2019S mutation (LRRK2G2019S), which is linked to sporadic and familial autosomal dominant forms of PD. We show that HD-LRRK2G2019S expression induced parkinsonian-like motor symptoms and histological features in less than 4 months

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

The G2019S mutation in the leucine-rich repeat kinase 2 (LRRK2) gene is the most common genetic cause of Parkinson's disease (PD), accounting for a significant proportion of both autosomal dominant familial and sporadic PD cases. Our aim in the present study is to generate a mammalian model of mutant G2019S LRRK2 pathogenesis, which reproduces the robust nigral neurodegeneration characteristic of PD. We developed adenoviral vectors to drive neuron-specific expression of full-length wild-type or mutant G2019S human LRRK2 in the nigrostriatal system of adult rats. Wild-type LRRK2 did not induce any significant neuronal loss. In contrast, under the same conditions and levels of expression, G2019S mutant LRRK2 causes a progressive degeneration of nigral dopaminergic neurons. Our data provide a novel rat model of PD, based on a prevalent genetic cause, that reproduces a cardinal feature of the disease within a rapid time frame suitable for testing of neuroprotective strategies