Shift Work and Women

Background: Shift workers face many physical, mental and social problems due to the disruption in the synchronization of their circadian rhythms, unusual working hours, exemption from social life as well as the negative impacts of such work. The purpose of the present study was to assess the different impacts of shift work on sleep, mental and social status among female textile workers in Denizli, Turkey.Methods: The study was carried out in 2012 at two different textile factories in Denizli-Turkey. A total of 799 workers took part in the study: 661 were shift workers and 138 were non-shift workers. Daytime sleepiness and quality of sleep were evaluated respectively via the Epworth Sleepiness Scale and Pittsburgh Sleep Quality Index. Polysomnographic examinations and psychiatric interviews were conducted on seven shift workers and 11 non-shift workers who exhibited daytime sleepiness.Results: The prevalence of daytime sleepiness was 20% and the rate of poor sleep quality was 61.5% among non-shift workers, while the rates were 15.4% and 83.5%, respectively among shift workers. It was observed that working shifts does not have an impact on daytime sleepiness, but is related to a 4.92-fold risk of poor sleep quality. In addition, risk of daytime sleepiness was 3.41 times higher in the presence of a mentally/physically disabled person in the family, 3.36 times higher if the person has an extra job, 3.15 times higher if the person suffered/suffers from a previous/current psychiatric disorder, and 1.17 times higher if the daily house work load of the individual is high.Conclusions: Working shifts disturbs sleep quality independent of many factors known to effect sleep. A history of previous or present psychiatric disorders increases the risk of daytime sleepiness.C1 [Ugurlu, Tugce Toker; Ozdel, Osman] Pamukkale Univ, Fac Med, Dept Psychiat, Denizli, Turkey.[Ugurlu, Erhan; Dursunoglu, Nese] Pamukkale Univ, Fac Med, Dept Pulmonol, Denizli, Turkey

Wkly Abstr Sanit Rep

19316859PMCnul

disease

This study aimed to investigate the relationship between endothelial nitric oxide synthase Glu(298)Asp gene polymorphism and hemorheological parameters. Red blood cell (RBC) deformability, aggregation were measured using an ectacytometry, whole blood, plasma viscosities were determined by a viscometer. Restriction fragment length polymorphism was used to detect polymorphism. Plasma nitrite, nitrate concentrations were determined by Griess method. The genotype distribution of the control group was as follows: 50 (67.5%) GG, 21 (28.4%) GT, 3 (4.1%) TT. A 48 (57.8%) of the patients with CAD had GG, 28 (33.7%) GT, 7 (8.5%) of them TT genotype. RBC aggregation index of CAD patients with G allele was higher and tA1/2 lower compared to controls carrying the same allele. The amplitude of RBC aggregation of healthy subjects with T allele, who are under increased cardiovascular risk was lower compared to control subjects with G allele. The results of this study indicate that, alterations in RBC aggregation seem to be a consequence of CAD, more than being a preexisting cause. Additionally, some compensatory mechanisms by causing decrements in RBC aggregation, may help regulation of circulation in healthy individuals with high cardiovascular risk

Relationship between hemorheology and Glu(298)Asp polymorphism of endothelial nitric oxide synthase gene in patients with coronary artery disease.

This study aimed to investigate the relationship between endothelial nitric oxide synthase Glu(298)Asp gene polymorphism and hemorheological parameters. Red blood cell (RBC) deformability, aggregation were measured using an ectacytometry, whole blood, plasma viscosities were determined by a viscometer. Restriction fragment length polymorphism was used to detect polymorphism. Plasma nitrite, nitrate concentrations were determined by Griess method. The genotype distribution of the control group was as follows: 50 (67.5%) GG, 21 (28.4%) GT, 3 (4.1%) TT. A 48 (57.8%) of the patients with CAD had GG, 28 (33.7%) GT, 7 (8.5%) of them TT genotype. RBC aggregation index of CAD patients with G allele was higher and t(1/2) lower compared to controls carrying the same allele. The amplitude of RBC aggregation of healthy subjects with T allele, who are under increased cardiovascular risk was lower compared to control subjects with G allele. The results of this study indicate that, alterations in RBC aggregation seem to be a consequence of CAD, more than being a preexisting cause. Additionally, some compensatory mechanisms by causing decrements in RBC aggregation, may help regulation of circulation in healthy individuals with high cardiovascular risk

Decreased plasma adiponectin concentrations in patients with syndrome X

Objective - The levels of adiponectin, an anti-atherogenic protein, are decreased in patients with coronary artery disease. Syndrome X is associated with endothelial dysfunction, which is a key feature in the evolution of atherosclerosis. We sought to determine whether serum adiponectin levels are decreased in patients with syndrome X.Methods - Twenty-three syndrome X patients (14 men, 9 women) who presented with stable angina pectoris, had a positive non-invasive stress test or an abnormal myocardial perfusion scintigraphy single photon emission computed tomography (MPS SPECT) and a normal coronary angiogram, were included in our study, as were 17 asymptomatic healthy subjects (13 men, 4 women) with normal results from non-invasive stress testing. The serum adiponectin levels and lipid profiles of the patients and control subjects were determined with venous samples collected after a 12-hour fast. The results were analysed by a Mann Whitney U test.Results - Mean age (54.1 +/- 11.8 y in patients and 59.8 +/- 9.6 y in control subjects, P>0.05) and body mass index (28.0 +/- 3.3 in patients and 27.1 +/- 4.2 in control subjects, P>0.05) did not differ between the two groups.Adiponectin levels in patients with syndrome X (1.5 +/- 1.1 mu g/dl) were significantly lower than those in the control group (5.3 +/- 2.9 mu g/dl, P 0.05).Conclusion - Serum adiponectin levels were lower in patients with syndrome X, and these low adiponectin concentrations may cause endothelial dysfunction. Thus, patients with a marked drop in adiponectin levels may be considered at high risk for future coronary events and may therefore benefit from additional pharmacological treatment

circumference

Background & aims: To investigate the relationship of neck circumference (NC) to metabolic syndrome (MetS) and obstructive sleep apnea syndrome (OSAS) and whether it adds information to that provided by waist circumference.Methods: Cross-sectional analysis of a population sample of 1912 men and women, aged 55.1 +/- 12 years, representative of Turkish adults. MetS was identified based on modified criteria of the ATP-III, OSAS when habitual snoring and episodes of apnea were combined with another relevant symptom.Results: NC measured 36.7 (+/- 3.5) cm in the total sample. It was significantly Correlated with numerous risk factors, above all body mass index and waist girth (r >= 0.6), homeostatic model-assessed insulin resistance, blood pressure and, inversely, with smoking status and sex hormone-binding globulin. Sex- and age-adjusted NC was associated significantly with MetS, at a 2-3-fold increased likelihood for 1 standard deviation (SD) increment. After further adjustment for waist circumference and smoking status, a significant residual odds ratio (OR, 1.13 [95% CI 1.08; 1.19]) persisted, corresponding to ORs of 1.53 and 1.27 in males and females, respectively, for 1 SO increment. Even when adjusted for all MetS components, a residual OR (1.08 [95% CI 1.000; 1.17]) remained. Sex- and age-adjusted NC was associated significantly also with OSAS in genders combined, independent of waist girth, yielding all added OR of 1.3 for 1 SD increment.Conclusions: NC contributes to MetS likelihood beyond waist circumference and the MetS components. Regarding association with OSAS, NC is of greater value than WC among Turkish men, not women. (c) 2008 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved