"Radioactive tracer methods applied to the study of reaction mechanisms"

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Perspectives on next steps in classification of oro-facial pain - part 1: role of ontology

The purpose of this study was to review existing principles of oro-facial pain classifications and to specify design recommendations for a new system that would reflect recent insights in biomedical classification systems, terminologies and ontologies. The study was initiated by a symposium organised by the International RDC/TMD Consortium Network in March 2013, to which the present authors contributed. The following areas are addressed: problems with current classification approaches, status of the ontological basis of pain disorders, insufficient diagnostic aids and biomarkers for pain disorders, exploratory nature of current pain terminology and classification systems, and problems with prevailing classification methods from an ontological perspective. Four recommendations for addressing these problems are as follows: (i) develop a hypothesis-driven classification structure built on principles that ensure to our best understanding an accurate description of the relations among all entities involved in oro-facial pain disorders; (ii) take into account the physiology and phenomenology of oro-facial pain disorders to adequately represent both domains including psychosocial entities in a classification system; (iii) plan at the beginning for field-testing at strategic development stages; and (iv) consider how the classification system will be implemented. Implications in relation to the specific domains of psychosocial factors and biomarkers for inclusion into an oro-facial pain classification system are described in two separate papers

Perspectives on next steps in classification of oro-facial pain - part 2: role of psychosocial factors

This study was initiated by a symposium, in which the present authors contributed, organised by the International RDC/TMD Consortium Network in March 2013. The purpose of the study was to review the status of biobehavioural research - both quantitative and qualitative - related to oro-facial pain (OFP) with respect to the aetiology, pathophysiology, diagnosis and management of OFP conditions, and how this information can optimally be used for developing a structured OFP classification system for research. In particular, we address representation of psychosocial entities in classification systems, use of qualitative research to identify and understand the full scope of psychosocial entities and their interaction, and the usage of classification system for guiding treatment. We then provide recommendations for addressing these problems, including how ontological principles can inform this process

Sublingual grass allergen tablet immunotherapy provides sustained clinical benefit with progressive immunologic changes over 2 years

Background: This is an interim analysis of a randomized, double-blind, placebo-controlled phase III trial with 3 years of daily treatment with grass tablet immunotherapy (GRAZAX; ALK-Abello A/S, Horsholm, Denmark) or placebo, followed by 2 years of follow-up to assess the persistent efficacy. Objective: We sought to evaluate the efficacy and safety of specific immunotherapy with grass allergen tablets compared with placebo after treatment covering 2 consecutive grass pollen seasons. Methods: The interim analyses included 351 adult participants with moderate-to-severe allergic rhinoconjunctivitis caused by grass pollen. Participants were treated with active (n = 189) or placebo (n = 162) tablets for an average of 22 months. All participants were allowed to use symptomatic rescue medication. Results: The primary efficacy analysis showed highly significant mean reductions of 36% in rhinoconjunctivitis symptom score (P Conclusion: Grass allergen tablet immunotherapy showed progressive immunologic changes and highly significant efficacy over 2 years of continued treatment

Study of UV Degradation on Plastic (PET) Aerosols

The present study was aimed to explore the impact of UV radiation, from ‘real world’ environmental exposure, on the degradation of plastic PET aerosol containers. Additionally, the intent was to correlate the ‘real world’ environmental exposure to artificial sunlight, using a Xenon-Arc lamp, to develop a simulated test. The standardized methodology could then be used to evaluate the integrity of the plastic aerosol container and product, without the complexity of using ‘real world’ exposure. Through this study, a lab method was developed and validated that would simulate the effect of UV radiation using the Xenon-Arc. Moreover, a correlation was made for conditions inside the Xenon-Arc chamber that were conducive to testing a plastic pressurized container

Parametric flutter studies of an arrow-wing configuration: Some early results

Some early experimental results from a combined experimental and analytical study being conducted at NASA-Langley of the transonic flutter characterisitics of a generic arrow wing configuration are presented. The planned study includes the parametric variation of a variety of structural and geometric characteristics. Presented here are flutter results of the basic arrow wing, for the basic wing with the addition of two simulated lower-surface-mounted engine nacelles, and for the basic wing with the addition of both the fin and the engine nacelles

The acheulean handaxe : More like a bird's song than a beatles' tune?

© 2016 Wiley Periodicals, Inc. KV is supported by the Netherlands Organization for Scientific Research. MC is supported by the Canada Research Chairs Program, the Social Sciences and Humanities Research of Canada, the Canada Foundation for Innovation, the British Columbia Knowledge Development Fund, and Simon Fraser UniversityPeer reviewedPublisher PD

Evolution of temperature-dependent charge transfer inefficiency correction for ACIS on the Chandra X-ray Observatory

As ACIS on the Chandra X-ray Observatory enters its seventeenth year of operation, it continues to perform well and produce spectacular scientific results. The response of ACIS has evolved over the lifetime of the observatory due to radiation damage and aging of the spacecraft. The ACIS instrument team developed a software tool which applies a correction to each X-ray event and mitigates charge transfer inefficiency (CTI) and spectral resolution degradation. The behavior of the charge traps that cause CTI are temperature dependent, however, and warmer temperatures reduce the effectiveness of the correction algorithm. As the radiator surfaces on Chandra age, ACIS cooling has become less efficient and temperatures can increase by a few degrees. A temperature-dependent component was added to the CTI correction algorithm in 2010. We present an evaluation of the effectiveness of this algorithm as the radiation damage and thermal environment continue to evolve and suggest updates to improve the calibration fidelity

Construction and Expected Performance of the Hadron Blind Detector for the PHENIX Experiment at RHIC

A new Hadron Blind Detector (HBD) for electron identification in high density hadron environment has been installed in the PHENIX detector at RHIC in the fall of 2006. The HBD will identify low momentum electron-positron pairs to reduce the combinatorial background in the $e^{+}e^{-}$ mass spectrum, mainly in the low-mass region below 1 GeV/c$^{2}$. The HBD is a windowless proximity-focusing Cherenkov detector with a radiator length of 50 cm, a CsI photocathode and three layers of Gas Electron Multipliers (GEM). The HBD uses pure CF$_{4}$ as a radiator and a detector gas. Construction details and the expected performance of the detector are described.Comment: QM2006 proceedings, 4 pages 3 figure