Year in review in Intensive Care Medicine 2009: II. Neurology, cardiovascular, experimental, pharmacology and sedation, communication and teaching

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Search for Supersymmetry in the single-lepton channel at CMS

Supersymmetry - one of the most promising candidates for a description of physics beyond the standard model - can manifest itself in a wide variety of different event topologies. Assuming the existence of a stable, weakly interacting lightest supersymmetric particle the final states are characterized by missing transverse energy. This poster shows results from a search for supersymmetry in events with a single lepton, jets and missing transverse energy in 36 pb-1 of proton-proton collision data recorded by the CMS experiment at a centre-of-mass energy of 7TeV. Standard model background estimations were obtained from data using several complementary methods. The results are interpreted in terms of limits in the parameter space of the constrained minimal supersymmetric extension of the standard model

Test Beam Results of a 3D Diamond Detector

3D pixel technology has been used successfully in the past with silicon detectors for tracking applications. Recently, a first prototype of the same 3D technology has been produced on a chemical vapour deposited single-crystal diamond sensor. This device has been subsequently tested in a beam test at CERN’s SPS accelerator in a beam of 120 GeV protons. Details on the production and results of testbeam data are presented

Measurements of the top-quark mass and properties at CMS

Measurements of of the top-quark mass and other top-quark properties are presented, obtained from the CMS data collected in 2011 and 2012 at centre-of-mass energies of 7 and 8 TeV. The mass of the top quark is measured using several methods and decay channels. The measurements of the top-quark properties include the W helicity in top-quark decays, the search for anomalous couplings, the ratio of bW/qW using both tt and single-top quark event samples. The results are compared with predictions from the standard model as well as new physics models. The cross section of tt events produced in association with a W, Z boson or a photon is also measured

Impact of early haemodynamic goal-directed therapy in patients undergoing emergency surgery: an open prospective, randomised trial

Haemodynamic goal-directed therapies (GDT) may improve outcome following elective major surgery. So far, few data exist regarding haemodynamic optimization during emergency surgery. In this randomized, controlled trial, 50 surgical patients with hypovolemic or septic conditions were enrolled and we compared two algorithms of GDTs based either on conventional parameters and pressure pulse variation (control group) or on cardiac index, global end-diastolic volume index and stroke volume variation as derived from the PiCCO monitoring system (optimized group). Postoperative outcome was estimated by a composite index including major complications and by the Sequential Organ Failure Assessment (SOFA) Score within the first 3 days after surgery (POD1, POD2 and POD3). Data from 43 patients were analyzed (control group, N = 23; optimized group, N = 20). Similar amounts of fluid were given in the two groups. Intraoperatively, dobutamine was given in 45 % optimized patients but in no control patients. Major complications occurred more frequently in the optimized group [19 (95 %) versus 10 (40 %) in the control group, P < 0.001]. Likewise, SOFA scores were higher in the optimized group on POD1 (10.2 ± 2.5 versus 6.6 ± 2.2 in the control group, P = 0.001), POD2 (8.4 ± 2.6 vs 5.0 ± 2.4 in the control group, P = 0.002) and POD 3 (5.2 ± 3.6 and 2.2 ± 1.3 in the control group, P = 0.01). There was no significant difference in hospital mortality (13 % in the control group and 25 % in the optimized group). Haemodynamic optimization based on volumetric and flow PiCCO-derived parameters was associated with a less favorable postoperative outcome compared with a conventional GDT protocol during emergency surgery