Speech discrimination difficulties in high-functioning autism spectrum disorder are likely independent of auditory hypersensitivity

Autism Spectrum Disorder (ASD), characterized by impaired communication skills and repetitive behaviors, can also result in differences in sensory perception. Individuals with ASD often perform normally in simple auditory tasks but poorly compared to typically developed (TD) individuals on complex auditory tasks like discriminating speech from complex background noise. A common trait of individuals with ASD is hypersensitivity to auditory stimulation. No studies to our knowledge consider whether hypersensitivity to sounds is related to differences in speech-in-noise discrimination. We provide novel evidence that individuals with high-functioning ASD show poor performance compared to TD individuals in a speech-in-noise discrimination task with an attentionally demanding background noise, but not in a purely energetic noise. Further, we demonstrate in our small sample that speech-hypersensitivity does not appear to predict performance in the speech-in-noise task. The findings support the argument that an attentional deficit, rather than a perceptual deficit, affects the ability of individuals with ASD to discriminate speech from background noise. Finally, we piloted a novel questionnaire that measures difficulty hearing in noisy environments, and sensitivity to non-verbal and verbal sounds. Psychometric analysis using 128 TD participants provided novel evidence for a difference in sensitivity to non-verbal and verbal sounds, and these findings were reinforced by participants with ASD who also completed the questionnaire. The study was limited by a small and high-functioning sample of participants with ASD. Future work could test larger sample sizes and include lower-functioning ASD participants

Massive post-starburst galaxies at z > 1 are compact proto-spheroids

We investigate the relationship between the quenching of star formation and the structural transformation of massive galaxies, using a large sample of photometrically-selected poststarburst galaxies in the UKIDSS UDS field. We find that post-starburst galaxies at highredshift (z > 1) show high Sérsic indices, significantly higher than those of active star-forming galaxies, but with a distribution that is indistinguishable from the old quiescent population. We conclude that the morphological transformation occurs before (or during) the quenching of star formation. Recently quenched galaxies are also the most compact; we find evidence that massive post-starburst galaxies (M_ > 1010:5 M_) at high redshift (z > 1) are on average smaller than comparable quiescent galaxies at the same epoch. Our findings are consistent with a scenario in which massive passive galaxies are formed from three distinct phases: (1) gas-rich dissipative collapse to very high densities, forming the proto-spheroid; (2) rapid quenching of star formation, to create the “red nugget” with post-starburst features; (3) a gradual growth in size as the population ages, perhaps as a result of minor mergers

The identification of post-starburst galaxies at z∼1 using multiwavelength photometry: a spectroscopic verification

Despite decades of study, we still do not fully understand why some massive galaxies abruptly switch off their star formation in the early Universe, and what causes their rapid transition to the red sequence. Post-starburst galaxies provide a rare opportunity to study this transition phase, but few have currently been spectroscopically identified at high redshift (z > 1). In this paper, we present the spectroscopic verification of a new photometric technique to identify post-starbursts in high-redshift surveys. The method classifies the broad-band optical–nearinfrared spectral energy distributions (SEDs) of galaxies using three spectral shape parameters (supercolours), derived from a principal component analysis of model SEDs. When applied to the multiwavelength photometric data in the UKIDSS Ultra Deep Survey, this technique identified over 900 candidate post-starbursts at redshifts 0.5 5 angstrem) and Balmer break, characteristic of post-starburst galaxies.We conclude that photometric methods can be used to select large samples of recently-quenched galaxies in the distant Universe

ISO Observations of the 53W002 Group at 6.7 microns: In Search of the Oldest Stellar Populations at z=2.4

We present a deep ISO observation at 6.7 microns of the 53W002 group of galaxies and AGN at z=2.4. This approximately samples the emitted K band. The faint, blue star-forming objects are not detected, as expected from their very blue color across the emitted optical and UV. However, 53W002 itself is detected at the 3-sigma level, with an emitted V-K color appropriate for a population formed starting at z=3.6-7.0 with most likely value z=4.7. This fits with shorter-wavelength data suggesting that the more massive members of this group, which may all host AGN, began star formation earlier in deeper potential wells than the compact Lyman-alpha emission objects. Two foreground galaxies are detected, as well as several stars. One additional 6.7-micron source closely coincides with an optically faint galaxy, potentially at z=2-3. The overall source counts are consistent with other ISO deep fields.Comment: In press, PASP (August 2004

Use of emerging technologies to help measure fjordic biodiversity and blue carbon: mini-manned submarines and autonomous underwater vehicle swarms

Meaningful protection of global oceans lags far behind that of land and has taken little consideration of climate mitigation potential to date (such as through assessment of blue carbon stocks and change). With the new emphasis on synergistic approaches to the identification and conservation of both carbon- and species- rich habitats, we need much better knowledge of the geography and status of blue carbon habitats beyond coastal wetlands. In subpolar and polar regions, some blue carbon habitats are still emerging and work as negative (mitigating) feedback on climate change, yet remain unprotected despite strong evidence of threat overlap. Scientific research expeditions are gradually increasing our understanding, but appropriate vessels are a limiting factor due to high costs and carbon footprints. Even when available such vessels cannot access all areas (e.g., remote fjords with sills) and may struggle to measure certain aspects of habitats (e.g., steep or vertical surfaces). New technologies and opportunities have advanced to aid some of these problems, and here, two of them are considered, mini-manned submersibles and autonomous underwater vehicles. These two platforms have both become much more available and affordable (through novel partnerships) while also being much more scientifically capable. This technology has the potential to reduce the carbon footprint of science and particularly aid in assessing biology and environment status and change on steep sides, such as fjord walls

Res Medica, Spring 1958, Volume 1, Number 2

TABLE OF CONTENTSTHE ROYAL MEDICAL SOCIETY TO-DAYTHE CONCEPTUAL BASIS OF MODERN SURGERY: Professor John Bruce, C.B.E., T.D., P. R.C.S.E., F.A.C.S. (HONS.)SOME PATHOLOGICAL ASPECTS OF DISSECTING ANEURYSM: M. J.MacLeanCHANGING FASHIONS IN DIABETES: Professor D. M. Dunlop, B.A., M.D., F. R.C. P. F. , F.R.C.P.OPERA OCCULTA: C. Vaughan RuckleySOME ASPECTS OF NUTRITIONAL AND TOXIC LIVER INJURY: A. W. DellipianiSIR JAMES YOUNG SIMPSON: William L.FordTHE AETIOLOGY OF DISSEMINATED SCLEROSIS: J. G. TurnbullHAZARDS OF RADIATION: Andrew Gun

High-velocity outflows in massive post-starburst galaxies at z > 1

We investigate the prevalence of galactic-scale outflows in post-starburst (PSB) galaxies at high redshift (1 1010M⊙⁠) PSBs at z > 1, there is clear evidence for a strong blue-shifted component to the Mg ii absorption feature, indicative of high-velocity outflows (⁠vout∼1150±160kms−1⁠) in the interstellar medium. We conclude that such outflows are typical in massive PSBs at this epoch, and potentially represent the residual signature of a feedback process that quenched these galaxies. Using full spectral fitting, we also obtain a typical stellar velocity dispersion σ* for these PSBs of ∼200kms−1⁠, which confirms they are intrinsically massive in nature (dynamical mass Md∼1011M⊙⁠). Given that these high-z PSBs are also exceptionally compact (re ∼ 1–2kpc⁠) and spheroidal (Sérsic index n ∼ 3), we propose that the outflowing winds may have been launched during a recent compaction event (e.g. major merger or disc collapse) that triggered either a centralized starburst or active galactic nuclei (AGN) activity. Finally, we find no evidence for AGN signatures in the optical spectra of these PSBs, suggesting they were either quenched by stellar feedback from the starburst itself, or that if AGN feedback is responsible, the AGN episode that triggered quenching does not linger into the post-starburst phase.Publisher PDFPeer reviewe

Quantifiable Biomarkers of Normal Aging in the Japanese Medaka Fish (Oryzias latipes)

BACKGROUND: Small laboratory fish share many anatomical and histological characteristics with other vertebrates, yet can be maintained in large numbers at low cost for lifetime studies. Here we characterize biomarkers associated with normal aging in the Japanese medaka (Oryzias latipes), a species that has been widely used in toxicology studies and has potential utility as a model organism for experimental aging research. PRINCIPAL FINDINGS: The median lifespan of medaka was approximately 22 months under laboratory conditions. We performed quantitative histological analysis of tissues from age-grouped individuals representing young adults (6 months old), mature adults (16 months old), and adults that had survived beyond the median lifespan (24 months). Livers of 24-month old individuals showed extensive morphologic changes, including spongiosis hepatis, steatosis, ballooning degeneration, inflammation, and nuclear pyknosis. There were also phagolysosomes, vacuoles, and residual bodies in parenchymal cells and congestion of sinusoidal vessels. Livers of aged individuals were characterized by increases in lipofuscin deposits and in the number of TUNEL-positive apoptotic cells. Some of these degenerative characteristics were seen, to a lesser extent, in the livers of 16-month old individuals, but not in 6-month old individuals. The basal layer of the dermis showed an age-dependent decline in the number of dividing cells and an increase in senescence-associated β-galactosidase. The hearts of aged individuals were characterized by fibrosis and lipofuscin deposition. There was also a loss of pigmented cells from the retinal epithelium. By contrast, age-associated changes were not apparent in skeletal muscle, the ocular lens, or the brain. SIGNIFICANCE: The results provide a set of markers that can be used to trace the process of normal tissue aging in medaka and to evaluate the effect of environmental stressors

An introduction to the co-creation of policy briefs with youth and academic teams

Drawing on insights from a four-day online workshop, which explored geo-engineering and policy making with 13 youth participants, an academic and youth authorial team provide a guide to the co-creation of policy briefs. Drawing on excerpts from the policy brief at different stages of development and commentary provided by the authors during the workshops, we set out four stages including (1) Identifying the key message and audience, (2) Reading and critically engaging with examples of policy briefs during the drafting process, (3) Developing the policy brief text, and (4) Reviewing and revising the policy brief. We have developed this guidance with a co-creative, group work approach in mind and suggest that this has relevance for those working in and beyond the discipline of geography