Optical off-nuclear spectra of quasar hosts and radio galaxies

We present optical (~3200A to ~9000A) off-nuclear spectra of 26 powerful active galaxies in the redshift range 0.1 < z < 0.3, obtained with the Mayall and William Herschel 4-meter class telescopes. The sample consists of radio-quiet quasars, radio-loud quasars (all with -23 > M_V > -26) and radio galaxies of Fanaroff & Riley Type II (with extended radio luminosities and spectral indices comparable to those of the radio-loud quasars). The spectra were all taken approximately 5 arcseconds off-nucleus, with offsets carefully selected so as to maximise the amount of galaxy light falling into the slit, whilst simultaneously minimising the amount of scattered nuclear light. The majority of the resulting spectra appear to be dominated by the integrated stellar continuum of the underlying galaxies rather than by light from the non-stellar processes occurring in the active nuclei, and in many cases a 4000A break feature can be identified. The individual spectra are described in detail, and the importance of the various spectral components is discussed. Stellar population synthesis modelling of the spectra will follow in a subsequent paper (Nolan et al. 2000).Comment: 23 pages, LaTeX, uses MNRAS style file, incorporates 71 postscript figures, to be published in MNRAS. Contact author: [email protected]

The ages of quasar host galaxies

We present the results of fitting deep off-nuclear optical spectroscopy of radio-quiet quasars, radio-loud quasars and radio galaxies at z ~ 0.2 with evolutionary synthesis models of galaxy evolution. Our aim was to determine the age of the dynamically dominant stellar populations in the hos t galaxies of these three classes of powerful AGN. Some of our spectra display residual nuclear contamination at the shortest wavelengths, but the detailed quality of the fits longward of the 4000A break provide unequivocal proof, if further proof were needed, that quasars lie in massive galaxies with (at least at z ~ 0.2) evolved stellar populations. By fitting a two-component model we have separated the very blue (starburst and/or AGN contamination) from the redder underlying spectral energy distribution, and find that the hosts of all three classes of AGN are dominated by old stars of age 8 - 14 Gyr. If the blue component is attributed to young stars, we find that, at most, 1% of the baryonic mass of these galaxies is involved in star-formation activity at the epoch of observation. These results strongly support the conclusion reached by McLure et al. (1999) that the host galaxies of luminous quasars are massive ellipticals which formed prior to the peak epoch of quasar activity at z ~ 2.5.Comment: 24 pages, LaTeX, uses MNRAS style file, incorporates 19 postscript figures, final version, to be published in MNRA

Successes and Challenges Associated with Solution Processing of Kesterite Cu2ZnSnS4 Solar Cells on Titanium Substrates

Roll-to-roll (R2R) processing of solution-based Cu2ZnSn(S,Se)4 (CZT(S,Se)) solar cells on flexible metal foil is an attractive way to achieve cost-effective manufacturing of photovoltaics. In this work we report the first successful fabrication of solution-processed CZTS devices on a variety of titanium substrates with up to 2.88% power conversion efficiency (PCE) collected on flexible 75 μm Ti foil. A comparative study of device performance and properties is presented aiming to address key processing challenges. First, we show that a rapid transfer of heat through the titanium substrates is responsible for the accelerated crystallisation of kesterite films characterised with small grain size, a high density of grain boundaries and numerous pore sites near the Mo/CZTS interface which affect charge transport and enhance recombination in devices. Following this, we demonstrate the occurrence of metal ion diffusion induced by the high temperature treatment required for the sulfurization of the CZTS stack: Ti4+ ions are observed to migrate upwards to the Mo/CZTS interface whilst Cu1+ and Zn2+ ions diffuse through the Mo layer into the Ti substrate. Finally, residual stress data confirm the good adhesion of stacked materials throughout the sequential solution process. These findings are evidenced by combining electron imaging observations, elemental depth profiles generated by secondary ion mass spectrometry, and x-ray residual stress analysis of the Ti substrate

Low-temperature behavior and memory of iron-rich titanomagnetites (Mt

Abstract We report low-temperature remanence and memory of octahedral crystals of titanomagnetite from Mt. Haruna, Japan and Mt. Pinatubo, Philippines. The crystals have Curie temperatures of 460^490 ‡C, indicating a low Ti content (0.11 9 x 9 0.16). Saturation isothermal remanence (SIRM) produced at 20 K decreased rapidly in warming through the isotropic temperature, 42 K 9 T i 9 55 K, where the first magnetocrystalline anisotropy constant K 1 changes sign and momentarily vanishes. 96^99% of the original SIRM was demagnetized at T i and none was recovered in recooling from 300 K to 20 K. SIRM produced at 300 K decreased continuously in the course of zero-field cooling, leveling out around T i . On rewarming to 300 K, 45^60% of the initial SIRM was recovered. This memory or recovered remanence is very large compared to that of magnetite and must be due to domain walls that are more strongly pinned, probably magnetostrictively by crystal defects, which are common in natural crystals. The present low-temperature experiments provide a quick, non-destructive method of identifying iron-rich titanomagnetites in soils, sediments and rocks.

The host galaxies of luminous quasars

We present results of a deep HST/WFPC2 imaging study of 17 quasars at z~0.4, designed to determine the properties of their host galaxies. The sample consists of quasars with absolute magnitudes in the range -24>M_V>-28, allowing us to investigate host galaxy properties across a decade in quasar luminosity, but at a single redshift. We find that the hosts of all the RLQs, and all the RQQs with nuclear luminosities M_V<-24, are massive bulge-dominated galaxies, confirming and extending the trends deduced from our previous studies. From the best-fitting model host galaxies we have estimated spheroid and black-hole masses, and the efficiency (with respect to Eddington luminosity) with which each quasar is radiating. The largest inferred black-hole mass in our sample is \~3.10^9 M_sun, comparable to those at the centres of M87 and Cygnus A. We find no evidence for super-Eddington accretion in even the most luminous objects. We investigate the role of scatter in the black-hole:spheroid mass relation in determining the ratio of quasar to host-galaxy luminosity, by generating simulated populations of quasars lying in hosts with a Schechter mass function. Within the subsample of the highest luminosity quasars, the observed variation in nuclear-host luminosity ratio is consistent with being the result of the scatter in the black-hole:spheroid relation. Quasars with high nuclear-host ratios can be explained by sub-Eddington accretion onto black holes in the high-mass tail of the black-hole:spheroid relation. Our results imply that, owing to the Schechter cutoff, host mass should not continue to increase linearly with quasar luminosity, at the very highest luminosities. Any quasars more luminous than M_V=-27 should be found in massive elliptical hosts which at the present day would have M_V ~ -24.5.Comment: Accepted for publication in MNRAS. 18 pages; 7 figures and 17 greyscale images are reproduced here at low quality due to space limitations. High-resolution figures are available from ftp://ftp.roe.ac.uk/pub/djef/preprints/floyd2004

Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4

Abstract Introduction Interleukin (IL)-17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis (CIA). Interferon(IFN)-γ and IL-4 have been shown to suppress Th17 development in vitro, but their potential immunoregulatory roles in vivo are uncertain. The goals of this study were to determine the relationship between Th17 responses and disease severity in CIA and to assess regulation of IL-17 by endogenous IFN-γ and IL-4. Methods DBA1/LacJ mice were immunized with type II collagen in complete Freund's adjuvant (CFA) to induce arthritis, and treated with neutralizing antibody to IFN-γ and/or IL-4. Systemic IL-17, IFN-γ, and IL-4 were measured in serum. At the peak of disease, cytokine production was measured by ELISA of supernatants from spleen, lymph node and paw cultures. Paws were also scored for histologic severity of arthritis. Results Joint inflammation was associated with a higher ratio of systemic IL-17/IFN-γ. Neutralization of IFN-γ accelerated the course of CIA and was associated with increased IL-17 levels in the serum and joints. The IFN-γ/IL-4/IL-17 responses in the lymphoid organ were distinct from such responses in the joints. Neutralization of IL-4 led to increased arthritis only in the absence of IFN-γ and was associated with increased bone and cartilage damage without an increase in the levels of IL-17. Conclusions IL-4 and IFN-γ both play protective roles in CIA, but through different mechanisms. Our data suggests that the absolute level of IL-17 is not the only determinant of joint inflammation. Instead, the balance of Th1, Th2 and Th17 cytokines control the immune events leading to joint inflammation.http://deepblue.lib.umich.edu/bitstream/2027.42/112787/1/13075_2009_Article_2675.pd

Massive post-starburst galaxies at z > 1 are compact proto-spheroids

We investigate the relationship between the quenching of star formation and the structural transformation of massive galaxies, using a large sample of photometrically-selected poststarburst galaxies in the UKIDSS UDS field. We find that post-starburst galaxies at highredshift (z > 1) show high Sérsic indices, significantly higher than those of active star-forming galaxies, but with a distribution that is indistinguishable from the old quiescent population. We conclude that the morphological transformation occurs before (or during) the quenching of star formation. Recently quenched galaxies are also the most compact; we find evidence that massive post-starburst galaxies (M_ > 1010:5 M_) at high redshift (z > 1) are on average smaller than comparable quiescent galaxies at the same epoch. Our findings are consistent with a scenario in which massive passive galaxies are formed from three distinct phases: (1) gas-rich dissipative collapse to very high densities, forming the proto-spheroid; (2) rapid quenching of star formation, to create the “red nugget” with post-starburst features; (3) a gradual growth in size as the population ages, perhaps as a result of minor mergers

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

PDE4 family cAMP phosphodiesterases play a pivotal role in determining compartmentalised cAMP signalling through targeted cAMP breakdown. Expressing the widely found PDE4D5 isoform, as both bait and prey in a yeast 2-hybrid system, we demonstrated interaction consistent with the notion that long PDE4 isoforms form dimers. Four potential dimerization sites were uncovered using a scanning peptide array approach, where a recombinant purified PDE4D5 fusion protein was used to probe a 25-mer library of overlapping peptides covering the entire PDE4D5 sequence. Key residues involved in PDE4D5 dimerization were defined using a site-directed mutagenesis programme directed by an alanine scanning peptide array approach. Critical residues stabilising PDE4D5 dimerization were defined within the regulatory UCR1 region found in long, but not short, PDE4 isoforms, namely the Arg173, Asn174 and Asn175 (DD1) cluster. Disruption of the DD1 cluster was not sufficient, in itself, to destabilise PDE4D5 homodimers. Instead, disruption of an additional interface, located on the PDE4 catalytic unit, was also required to convert PDE4D5 into a monomeric form. This second dimerization site on the conserved PDE4 catalytic unit is dependent upon a critical ion pair interaction. This involves Asp463 and Arg499 in PDE4D5, which interact in a trans fashion involving the two PDE4D5 molecules participating in the homodimer. PDE4 long isoforms adopt a dimeric state in living cells that is underpinned by two key contributory interactions, one involving the UCR modules and one involving an interface on the core catalytic domain. We propose that short forms do not adopt a dimeric configuration because, in the absence of the UCR1 module, residual engagement of the remaining core catalytic domain interface provides insufficient free energy to drive dimerization. The functioning of PDE4 long and short forms is thus poised to be inherently distinct due to this difference in quaternary structure