On Himalay

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The cost-effectiveness of procalcitonin for guiding antibiotic prescribing in individuals hospitalized with COVID-19: part of the PEACH study

Background Many hospitals introduced procalcitonin (PCT) testing to help diagnose bacterial coinfection in individuals with COVID-19, and guide antibiotic decision-making during the COVID-19 pandemic in the UK. Objectives Evaluating cost-effectiveness of using PCT to guide antibiotic decisions in individuals hospitalized with COVID-19, as part of a wider research programme. Methods Retrospective individual-level data on patients hospitalized with COVID-19 were collected from 11 NHS acute hospital Trusts and Health Boards from England and Wales, which varied in their use of baseline PCT testing during the first COVID-19 pandemic wave. A matched analysis (part of a wider analysis reported elsewhere) created groups of patients whose PCT was/was not tested at baseline. A model was created with combined decision tree/Markov phases, parameterized with quality-of-life/unit cost estimates from the literature, and used to estimate costs and quality-adjusted life years (QALYs). Cost-effectiveness was judged at a £20 000/QALY threshold. Uncertainty was characterized using bootstrapping. Results People who had baseline PCT testing had shorter general ward/ICU stays and spent less time on antibiotics, though with overlap between the groups’ 95% CIs. Those with baseline PCT testing accrued more QALYs (8.76 versus 8.62) and lower costs (£9830 versus £10 700). The point estimate was baseline PCT testing being dominant over no baseline testing, though with uncertainty: the probability of cost-effectiveness was 0.579 with a 1 year horizon and 0.872 with a lifetime horizon. Conclusions Using PCT to guide antibiotic therapy in individuals hospitalized with COVID-19 is more likely to be cost-effective than not, albeit with uncertainty

The ash grove : Welsh folk-song /

Caption title.Includes piano reduction for rehearsal only.For mixed voices (SATB), unacc.Mode of access: Internet

The mother's lament : Irish folk-song /

Caption title.Includes piano reduction for rehearsal only.For mixed voices (SATB), unacc.Mode of access: Internet

A celtic lullaby [music] : op. 45 no. 4 /

B.9033 (Publisher number). "For piano" -- Cover.; Pl. no.: B.9033.; Also available online http://nla.gov.au/nla.mus-an13411042

The meeting of the waters : old Irish melody /

Caption title.Includes piano reduction for rehearsal only.For mixed voices (SATB), unacc.Mode of access: Internet

The cloths of heaven / Thomas F. Dunhill, words by William Butler Yeats

From the song cycle The wind among the reeds. ; Piano vocal score in C. ; Pl. no. : S.& B. Ltd. 1906