227 research outputs found

    A Method and a Device for Diagnostics of the Functional State of Peripheral Vessels of the Upper Limbs

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    The article suggests a method and a device for diagnostics of the functional state of peripheral vessels of the upper limbs, which provide identification of angiospastic disorders with a lower probability of falsenegative result, allowing thereby the quality of diagnostics to be improved. The suggested approach is based on combined application of laser Doppler flowmetry and contact thermometry during an occlusion test. The obtained results can be used in various fields of medicine for the development of multifunctional noninvasive diagnostic systems for the diagnosis and prevention of diseases associated with changes in the functional state of peripheral vessels

    Integral pattern of bench stability on all adjacent rock of open-pit mine in solid rocks

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    The article presents the integrated image of bench stability across the entire adjacent pit area on the basis of a probabilistic method to predict the azimuthangular parameters of cracks that limit the potential prisms of the pit bench collapse that are put in the final position, as well as those planned to be set to the limiting contour in the form of a software component as the part of the specialized geoinformation GIS system "Stability

    New trophic classification of wood-destroying fungi the case of community of pathogenic polypore fungi types on Pedunculate oak

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    Based on the generalization of experimental data obtained during the practical study of the trophic specialization of wood-destroying fungi from the commonness of PTH on oak in the oak forests of the south-west of the Central Russian Upland, a new ecotrophic classification has been developed, including the following groups of wood-destroying fungi: biotrophic pathogens, saprotrophic pathogens, pathogenic saprotrophs, non-pathogenic saprotroph

    Assessment of the Size of Rocks in Benchs and Lumpiness of the Blasted Mountain Mass on Pits with Use of Gis Geomix

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    On the basis of natural researches in career of SC Kovdorsky MCP and computer processing of their results in GIS GEOMIX was developed the photometric method of assessment of blocks (sizes) of breeds in the slope of ledges of a pit, the existing version of this method intended for assessment of lumpiness of mountain mass is improve

    Multimodal optical diagnostics of the microhaemodynamics in upper and lower limbs

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    The introduction of optical non-invasive diagnostic methods into clinical practice can substantially advance in the detection of early microcirculatory disorders in patients with different diseases. This paper is devoted to the development and application of the optical non-invasive diagnostic approach for the detection and evaluation of the severity of microcirculatory and metabolic disorders in rheumatic diseases and diabetes mellitus. The proposed methods include the joint use of laser Doppler flowmetry, absorption spectroscopy and fluorescence spectroscopy in combination with functional tests. This technique showed the high diagnostic importance for the detection of disturbances in peripheral microhaemodynamics. These methods have been successfully tested as additional diagnostic techniques in the field of rheumatology and endocrinology. The sensitivity and specificity of the proposed diagnostic procedures have been evaluated.<br/

    Opportunities for the analysis of the spatial ecological structure of the mycobiota of macromycetes of a natural-territorial entity (the case of the Botanical Garden of Belgorod University, Belgorod, Russia)

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    On the basis of direct observations, the general principles of the organization of the mycobiota of the macromycetes of the natural-territorial formation "Botanical Garden" of Belgorod State University (Belgorod, Russian Federation) have been clarified. Based on the clarified principles, a scheme of their spatial ecological organization has been constructed: mycobiota - mycohore (mycocenosis, mycoaggregation) - mycosinium-3 - mycocenocells - mycocell. The obtained results can be used to study the spatial ecological organization of mycobiota macromycetes of other natural-territorial formation

    Trans-species relation in communities of pathogenic Polyporaceae on pedunculate oak Quercus robur L

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    In the process of research phytopathological and mycocenological methods were used As a result of the research, real trans-species relation were revealed in the most common and frequently occurring types of PPF on oak within various communities: Mutually positive type relationships based on the proto-operation were found between Laetiporus sulphureus and Fistulina hepatica. Neutral type relationships were found in between Fistulina hepatica and Fomitiporia robusta, Laetiporus sulphureus and Fomitiporia robust

    ΠœΠ΅Ρ‚ΠΎΠ΄ ΠΈ устройство ΠΎΡ†Π΅Π½ΠΊΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ состояния микроциркуляторно-Ρ‚ΠΊΠ°Π½Π΅Π²Ρ‹Ρ… систСм ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° основС ΠΌΡƒΠ»ΡŒΡ‚ΠΈΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΎΠΉ оптичСской диагностики

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    Introduction. Violations of the microcirculatory-tissue systems of the human body play a key role in the pathogenesis of various diseases complications. However, there are a few unresolved methodological and instrumental problems with non-invasive monitoring of microcirculatory function and metabolic disorders associated with insufficient accuracy, reproducibility and informativeness of diagnostic results. The proposed approach of multiparametric optical diagnostics, when optical non-invasive technologies are used in combination, can be a promising tool that improves the sensitivity and accuracy of detecting microcirculatory and metabolic disorders at an early stage, which is important for the diagnosis and treatment of diseases of various profiles.Aim. Development of a method and device for assessing the functional state of microcirculatory-tissue systems of the human body based on multiparametric optical diagnostics and assessment of its diagnostic potential in clinical practice.Materials and methods. In the paper, theories of radiation transfer, applied mathematical statistics and clinical research methods are used. The statistical indicators of the developed diagnostic methods are given, the principle of the device construction is described.Results. An original method and principle for constructing a device for assessing the functional state of microcirculatory-tissue systems of the human body based on multiparametric optical diagnostics has been developed.Conclusion. The present work presents a method and device for assessing the functional state of microcirculatory-tissue systems of the human body based on this approach. The basic principles of each of the diagnostic channels (laser Doppler flowmetry, fluorescence spectroscopy and diffuse reflectance spectroscopy) are described. Examples of the clinical application of the described device in various fields of medicine (endocrinology, rheumatology, minimally invasive surgery) are presented. The method proposed in this article and principle for constructing a device with the possibility of its technical adaptation by developing additional probes for specific tasks of biomedical research makes optical non-invasive diagnostics affordable and increases its information content.Π’Π²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΠ°Ρ€ΡƒΡˆΠ΅Π½ΠΈΡ Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ микроциркуляторно-Ρ‚ΠΊΠ°Π½Π΅Π²Ρ‹Ρ… систСм ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΈΠ³Ρ€Π°ΡŽΡ‚ ΠΊΠ»ΡŽΡ‡Π΅Π²ΡƒΡŽ Ρ€ΠΎΠ»ΡŒ Π² ΠΏΠ°Ρ‚ΠΎΠ³Π΅Π½Π΅Π·Π΅ ослоТнСний Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. Однако ΠΏΡ€ΠΈ Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΌ ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€ΠΈΠ½Π³Π΅ микроциркуляторной Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΈ ΠΈ мСтаболичСских Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠΉ сущСствуСт ряд Π½Π΅Ρ€Π΅ΡˆΠ΅Π½Π½Ρ‹Ρ… мСтодологичСских ΠΈ ΠΈΠ½ΡΡ‚Ρ€ΡƒΠΌΠ΅Π½Ρ‚Π°Π»ΡŒΠ½Ρ‹Ρ… ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌ, связанных с нСдостаточной Ρ‚ΠΎΡ‡Π½ΠΎΡΡ‚ΡŒΡŽ, Π²ΠΎΡΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒΡŽ ΠΈ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒΡŽ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² диагностики. ΠŸΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Ρ‹ΠΉ Π² настоящСй ΡΡ‚Π°Ρ‚ΡŒΠ΅ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ ΠΌΡƒΠ»ΡŒΡ‚ΠΈΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΎΠΉ оптичСской диагностики, ΠΏΡ€ΠΈ ΠΊΠΎΡ‚ΠΎΡ€ΠΎΠΌ оптичСскиС Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½Ρ‹Π΅ Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡ€ΠΈΠΌΠ΅Π½ΡΡŽΡ‚ΡΡ Π² сочСтанном Π²ΠΈΠ΄Π΅, ΠΌΠΎΠΆΠ΅Ρ‚ ΡΡ‚Π°Ρ‚ΡŒ пСрспСктивным инструмСнтом, ΡƒΠ»ΡƒΡ‡ΡˆΠ°ΡŽΡ‰ΠΈΠΌ Ρ‡ΡƒΠ²ΡΡ‚Π²ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΈ Ρ‚ΠΎΡ‡Π½ΠΎΡΡ‚ΡŒ выявлСния микроциркуляторных ΠΈ мСтаболичСских Π½Π°Ρ€ΡƒΡˆΠ΅Π½ΠΈΠΉ Π½Π° Ρ€Π°Π½Π½Π΅ΠΉ стадии, Ρ‡Ρ‚ΠΎ Π²Π°ΠΆΠ½ΠΎ для диагностики ΠΈ лСчСния Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠ³ΠΎ профиля.ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠ° ΠΌΠ΅Ρ‚ΠΎΠ΄Π° ΠΈ устройства для ΠΎΡ†Π΅Π½ΠΊΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ состояния микроциркуляторно-Ρ‚ΠΊΠ°Π½Π΅Π²Ρ‹Ρ… систСм ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° основС ΠΌΡƒΠ»ΡŒΡ‚ΠΈΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΎΠΉ оптичСской диагностики ΠΈ ΠΎΡ†Π΅Π½ΠΊΠ° ΠΈΡ… диагностичСского ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»Π° Π² клиничСской ΠΏΡ€Π°ΠΊΡ‚ΠΈΠΊΠ΅.ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ Ρ€Π°Π±ΠΎΡ‚Π΅ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½Ρ‹ Ρ‚Π΅ΠΎΡ€ΠΈΠΈ пСрСноса излучСния, ΠΏΡ€ΠΈΠΊΠ»Π°Π΄Π½ΠΎΠΉ матСматичСской статистики ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² клиничСских исслСдований. ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ статистичСскиС ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π½Ρ‹Ρ… ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² диагностики, описан ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏ построСния устройства.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Π Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½ ΠΎΡ€ΠΈΠ³ΠΈΠ½Π°Π»ΡŒΠ½Ρ‹ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΈ ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏ построСния устройства для ΠΎΡ†Π΅Π½ΠΊΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ состояния микроциркуляторно-Ρ‚ΠΊΠ°Π½Π΅Π²Ρ‹Ρ… систСм ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° основС ΠΌΡƒΠ»ΡŒΡ‚ΠΈΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΎΠΉ оптичСской диагностики.Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’ настоящСй ΡΡ‚Π°Ρ‚ΡŒΠ΅ прСдставлСн ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΈ устройство для ΠΎΡ†Π΅Π½ΠΊΠΈ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ состояния микроциркуляторно-Ρ‚ΠΊΠ°Π½Π΅Π²Ρ‹Ρ… систСм ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΌΠ° Ρ‡Π΅Π»ΠΎΠ²Π΅ΠΊΠ° Π½Π° основС ΡƒΠΊΠ°Π·Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π°. ΠžΠΏΠΈΡΠ°Π½Ρ‹ основныС ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏΡ‹ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· диагностичСских ΠΊΠ°Π½Π°Π»ΠΎΠ² – Π»Π°Π·Π΅Ρ€Π½ΠΎΠΉ доплСровской Ρ„Π»ΠΎΡƒΠΌΠ΅Ρ‚Ρ€ΠΈΠΈ, флуорСсцСнтной спСктроскопии ΠΈ спСктроскопии Π΄ΠΈΡ„Ρ„ΡƒΠ·Π½ΠΎΠ³ΠΎ отраТСния. ΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Ρ‹ ΠΏΡ€ΠΈΠΌΠ΅Ρ€Ρ‹ клиничСского примСнСния описанного устройства Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… областях ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ‹ (эндокринология, рСвматология, ΠΌΠΈΠ½ΠΈ-инвазивная хирургия). ΠŸΡ€Π΅Π΄Π»ΠΎΠΆΠ΅Π½Π½Ρ‹ΠΉ ΠΌΠ΅Ρ‚ΠΎΠ΄ ΠΈ ΠΏΡ€ΠΈΠ½Ρ†ΠΈΠΏ построСния устройства с Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒΡŽ Π΅Π³ΠΎ тСхничСской Π°Π΄Π°ΠΏΡ‚Π°Ρ†ΠΈΠΈ Π·Π° счСт Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ Π΄ΠΎΠΏΠΎΠ»Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… Π·ΠΎΠ½Π΄ΠΎΠ² для ΠΊΠΎΠ½ΠΊΡ€Π΅Ρ‚Π½Ρ‹Ρ… Π·Π°Π΄Π°Ρ‡ биомСдицинских исслСдований Π΄Π΅Π»Π°Π΅Ρ‚ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ оптичСской Π½Π΅ΠΈΠ½Π²Π°Π·ΠΈΠ²Π½ΠΎΠΉ диагностики доступным ΠΈ ΠΏΠΎΠ²Ρ‹ΡˆΠ°Π΅Ρ‚ Π΅Π΅ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ

    Novel wearable VCSEL-based blood perfusion sensor

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    A wearable 850 nm VCSEL-based blood perfusion sensor operating on the principles of laser Doppler flowmetry (LDF) and Dynamic Light Scattering (DLS) has been developed and tested. The sensitivity of the sensor to changes in skin blood perfusion has been demonstrated

    Blood flow oscillations as a signature of microvascular abnormalities

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    Laser Doppler flowmetry (LDF) was utilized for blood ow measurements. Wavelet analysis was used to identify spectral characteristics of the LDF signal in patients with rheumatic diseases and diabetes mellitus. Baseline measurements were applied for both pathological groups. Blood flow oscillations analyses were performed by means of the wavelet transform. Higher baseline perfusion was observed in both pathological groups in comparison to controls. Differences in the spectral properties between the groups studied were revealed. The results obtained demonstrated that spectral properties of the LDF signal collected in basal conditions may be the signature of microvasculature functional state
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