Life-prolonging treatment restrictions and outcomes in patients with cancer and COVID-19:an update from the Dutch Oncology COVID-19 Consortium

AIM OF THE STUDY: The coronavirus disease 2019 (COVID-19) pandemic significantly impacted cancer care. In this study, clinical patient characteristics related to COVID-19 outcomes and advanced care planning, in terms of non-oncological treatment restrictions (e.g. do-not-resuscitate codes), were studied in patients with cancer and COVID-19. METHODS: The Dutch Oncology COVID-19 Consortium registry was launched in March 2020 in 45 hospitals in the Netherlands, primarily to identify risk factors of a severe COVID-19 outcome in patients with cancer. Here, an updated analysis of the registry was performed, and treatment restrictions (e.g. do-not-intubate codes) were studied in relation to COVID-19 outcomes in patients with cancer. Oncological treatment restrictions were not taken into account. RESULTS: Between 27th March 2020 and 4th February 2021, 1360 patients with cancer and COVID-19 were registered. Follow-up data of 830 patients could be validated for this analysis. Overall, 230 of 830 (27.7%) patients died of COVID-19, and 60% of the remaining 600 patients with resolved COVID-19 were admitted to the hospital. Patients with haematological malignancies or lung cancer had a higher risk of a fatal outcome than other solid tumours. No correlation between anticancer therapies and the risk of a fatal COVID-19 outcome was found. In terms of end-of-life communication, 50% of all patients had restrictions regarding life-prolonging treatment (e.g. do-not-intubate codes). Most identified patients with treatment restrictions had risk factors associated with fatal COVID-19 outcome. CONCLUSION: There was no evidence of a negative impact of anticancer therapies on COVID-19 outcomes. Timely end-of-life communication as part of advanced care planning could save patients from prolonged suffering and decrease burden in intensive care units. Early discussion of treatment restrictions should therefore be part of routine oncological care, especially during the COVID-19 pandemic

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Changes and Perspectives in Food Studies

Food Studies represent the bases for multidisciplinary knowledge in food science, food engineering, food management, and how to use these scientific bases in a food worldwide context. Teaching and learning must be adapted to the new students, to the new tools, considering the cost of studies and equipment. The international availability of raw materials, the diversity of cultures, tastes and habits must be taken into account in the controlled food processes. Food engineering must be taught with reference to nutrition, health and security, but also to packaging, logistics, international rules, management of water, energy, wastes and cost. So how do we teach the present and future food engineers, to help them to acquire and build their own knowledge, to develop curiosity, an open mind and team work? How do we teach them to use, in an efficient way, computers, data bases, the internet, but also to learn and practice in the lab, on pilot equipment, in the plant during long internships? How do we give them the desire to conceive, to create, to manage, to communicate and to continue to learn during their professional life? International networks of universities, with associated people from research and industry, with teachers in elementary and secondary schools, with students, represent a main factor for reciprocal knowledge and exchanges, to preserve and use diversity to develop new ideas for teaching and learning. The objectives are to contribute to the development of our society, to feed in an harmonized way the world made of human beings, consumers, and workers in industry, research and universities.<br /

The AgroParisTech “Social Openings” mission

International audienceUnderprivileged secondary school and college students tend to demonstrate limited ambitions with regards to further education and acquiring superior qualifications. In a partnership with higher education schools, such as AgroParisTech, encounters have been organised between high school students and higher education students acting as volunteering mentors.The aim is to present the high school students with the opportunity to explore new opportunities as well as to provide them with information about high profile careers and higher level training through various activities led by the higher education students, as well as through meetings, visits, weekends organised around a specific theme. Examples of such initiatives show what benefits both the high school and higher education students can derive from them

Séchage par atomisation (prorpiétés des collages des particules en relation avec l'agglomération)

MASSY-AgroParisTech (913772301) / SudocSudocFranceF

Aroma encapsulation in powder by spray drying, and fluid bed agglomeration and coating

11. International Congress on Engineering and Food (ICEF) - Athens (Grèce) - 22-26 mai 2011Aroma encapsulation in powder by spray drying, and fluid bed agglomeration and coatin

Encapsulation of aroma

Encapsulation of arom

Instrumentation d'un four pilote pour la cuisson de génoise

MASSY-AgroParisTech (913772301) / SudocSudocFranceF

Fluidised bed agglomeration of particles with different glass transition temperatures

Fluidised bed agglomeration of particles consists in spraying liquid drops (water or binder solution) on the surface of particles, fluidised by hot air, in order to create sticky regions to allow formation of agglomerates when the sticky particles collide. Many parameters influence agglomerate growth, especially those controlling the particle circulation, and the water and temperature conditions within the bed that determine drying and particle stickiness linked to the glass transition of amorphous components and to the viscosity of moist zones at the particle surface. Maltodextrin DE12 and DE21 particles with different glass transition temperature domains were agglomerated in a batch bench scale fluidised bed, under constant mechanical constraints, changing the sprayed water feed rate and the fluidisation air temperature in order to investigate the influence of particle stickiness on agglomerate growth kinetics and mechanism. The two powders showed a different sensitivity to the water and temperature constraints applied. Whilst for maltodextrin DE12, the size and growth rate increased significantly with the sprayed water flow rate, only a small variation was observed for maltodextrin DE21. In both cases, agglomeration occurred in two stages: firstly, the association of initial particles and secondly the agglomeration of intermediate agglomerates into larger and more porous structures. The change from one growth mechanism to the other depended on the conditions, and influenced the size distribution and structure of agglomerates