Numerical and experimental comparison of confinement effects on a fully-passive oscillating-foil turbine

A numerical and experimental comparison of a fully-passive oscillating-foil turbine operating in different confinement levels is conducted to assert how well CFD-based FSI simulations can predict the performances of the turbine. It is found the present 3D URANS simulations match reasonably well the experimental observations, especially in terms of pitch angles and power extraction. Indeed, the results confirm that confinement increases the extracted power and the efficiency of the fully-passive blade. At low confinement level, the main flow features are shown to be well captured by the simulations. At large confinement levels, some issues with lateral walls interactions are discussed as possible explanation for the observed discrepancies

The Creative Stereotype Effect

Funding for Open Access provided by the UMD Libraries Open Access Publishing Fund.Because of its fundamental relevance to scientific innovation, artistic expression, and human ingenuity, creativity has long been the subject of systematic psychological investigation. Concomitantly, the far-reaching effects of stereotypes on various cognitive and social processes have been widely researched. Bridging these two literatures, we show in a series of two studies that stereotypes related to creativity can both enhance and diminish individuals’ performance on a divergent thinking task. Specifically, Study 1 demonstrated that participants asked to take on a stereotypically uninhibited perspective performed significantly better on a divergent thinking task than those participants who took on a stereotypically inhibited perspective, and a control group. Relatedly, Study 2 showed that the same effect is found within-subjects, with divergent thinking significantly improving when participants invoke an uninhibited stereotype. Moreover, we demonstrate the efficacy of Latent Semantic Analysis as an objective measure of the originality of ideas, and discuss implications of our findings for the nature of creativity. Namely, that creativity may not be best described as a stable individual trait, but as a malleable product of context and perspective

Missense-depleted regions in population exomes implicate ras superfamily nucleotide-binding protein alteration in patients with brain malformation.

Genomic sequence interpretation can miss clinically relevant missense variants for several reasons. Rare missense variants are numerous in the exome and difficult to prioritise. Affected genes may also not have existing disease association. To improve variant prioritisation, we leverage population exome data to identify intragenic missense-depleted regions (MDRs) genome-wide that may be important in disease. We then use missense depletion analyses to help prioritise undiagnosed disease exome variants. We demonstrate application of this strategy to identify a novel gene association for human brain malformation. We identified de novo missense variants that affect the GDP/GTP-binding site of ARF1 in three unrelated patients. Corresponding functional analysis suggests ARF1 GDP/GTP-activation is affected by the specific missense mutations associated with heterotopia. These findings expand the genetic pathway underpinning neurologic disease that classically includes FLNA. ARF1 along with ARFGEF2 add further evidence implicating ARF/GEFs in the brain. Using functional ontology, top MDR-containing genes were highly enriched for nucleotide-binding function, suggesting these may be candidates for human disease. Routine consideration of MDR in the interpretation of exome data for rare diseases may help identify strong genetic factors for many severe conditions, infertility/reduction in reproductive capability, and embryonic conditions contributing to preterm loss

Données récentes sur l’occupation humaine dans les Alpes méridionales durant l’Antiquité

Parmi les nombreux travaux portant sur l’occupation du milieu alpin, très peu concernent la période antique. Les recherches, souvent anciennes, se sont focalisées sur des questions telles que les grandes voies transalpines, l’organisation administrative des régions alpines ou le développement urbain. L’occupation de ces régions était principalement appréhendée à travers quelques découvertes ou des fouilles anciennes, principalement dans les fonds de vallées des Alpes du Nord. Le développement de l’archéologie préventive a permis d’acquérir de nouvelles connaissances dans les zones basses mais ce sont surtout les recherches entreprises, depuis une dizaine d’années dans les Alpes méridionales, qui ont fait progresser les connaissances sur le peuplement de la montagne, en appréhendant ce milieu dans son ensemble, depuis les vallées jusqu’à la haute montagne.Amongst the many research projects dealing with the occupation of alpine landscapes, very few directly deal with the Roman period. Older research projects often emphasised the study of the major trans-Alpine routes, or the administrative organisation of the urban zones in the Alps. The settlement of these regions was primarily based on data from earlier excavations, mainly from the valley bottoms of the northernAlps. Rescue (or salvage) archaeology has enhanced our knowledge of lowland alpine archaeology, but it is the research undertaken during the past decade in the Southern Alps that increased our understanding of mountain populations covering all altitudes from valley bottoms to the high altitudes

The Grizzly, September 15, 1989

Greek Golden Age Growing Dark • U.C. Slasher Case Finally Closed • Letters: Physics Major Majorly Miffed; Wismer Eggs on Disgusted Diner • SAO Makes Room for Zimmer • Go Abroad: It\u27s Worth It • Mann\u27s Soda Can Hit with Crowd • Bears Upset Hoyas in Season Opener • Grizzlies Take Tourney with Defense • V-ball: Victors! • Endurance is Key • Athletes of the Week • Pledging: Git! • Myrin Booking • Lucas Heads Frosh Seminar • Dumas: Cook of Monte Cristo • Smith Donation • Freshmen Make Necessary Adjustmentshttps://digitalcommons.ursinus.edu/grizzlynews/1240/thumbnail.jp

The Grizzly, October 13, 1989

Berman Opening Draws Near • Sculptor Chadwick Visits UC • Frats Angered • Letters: Grizzly, Get on the Ball!; Shape up!; Dump Starkist! • Michener Opens Museum • Swarthmore, Hopkins Defeated • V-Ball Wins • Hockey Squad Beats Nationally Ranked Teams • 1989 Candidates for Homecoming Queen • Soccer Looks to Future • Wagner Runs Wild • Athletes of the Week • Control Pledging Power Abuses • The Wismer Beastieshttps://digitalcommons.ursinus.edu/grizzlynews/1243/thumbnail.jp

Aqueduc et structures hydrauliques de la <i>villa</i> de Richeaume I à Puyloubier (Bouches-du-Rhône)

International audienceEine von 1998 bis 2003 an der antiken Fundstelle von Richeaume I (Puyloubier, Dép. Bouches-du-Rhône) durchgeführte Plangrabung führte zur Entdeckung einer ausgedehnten Villenanlage. Sie nimmt eine Fläche von mehr als 5.000 m2 ein und war vom ersten Jahrhundert v. Chr. bis zu Beginn des sechsten Jahrhunderts n. Chr. belegt. Sie war durch eine Wasserleitung versorgt, die die Quellen im Norden des Geländes faβt, und von einer bestimmten Anzahl ländlicher Siedelplätze umgeben, die häufig schon in der jüngeren Eisenzeit bestanden. Die auf 2.000 m2 freigelegten archäologischen Überreste betreffen die Wohnbereiche und die landwirtschaftlichen Bereiche der frühkaiserzeitlichen und spätantiken Villa sowie verschiedene wasserbauliche Vorrichtungen (Zierbecken, Leitungskanäle, Abwasserleitungen, Staumauern, Entwässerungsgräben und Reste der Wasserleitung). Die hier vorgetragenen Überlegungen beziehen sich auf die wasserbaulichen Anlagen, die durch geophysikalische Prospektion und archäologische Grabungen auf dem Osthang des Platzes zwischen 315,94 m und 314,05 m ü. N. N. entdeckt wurden. Von diesen Anlagen (Staumauer, Altarm eines Gewässerlaufs, Abschnitte der Wasserleitung) fallen insbesondere Überreste einer Wasserleitung auf die man nur mit der Wasserversorgung der Wohn- und Stallbereiche der weiter bergauf gelegenen Villa in Verbindung bringen kann. Die beschriebene Vorrichtung, bei der die stark abschüssige Hanglage die Errichtung eines gewaltigen Unterbaus erzwang, dürfte mit der Versorgung eines der benachbarten Gebäude zusammenhängen, dessen genaue Funktion noch zu untersuchen wäre.A research excavation on the Richeaume I site (Puyloubier, Bouches-du-Rhône) took place between 1998 and 2003. This revealed the presence of a substantial villa, covering an area of 5 000 m2 that was occupied from the 1st century BC through to the 4th century AD. An aqueduct, which channelled water from a number of springs to the north of the site, supplied the site. A number of other sites that were initially settled during the late Iron Age surround Richeaume I. The archaeological remains excavated covered an area of 2 000 m2 and revealed elements of the agricultural and domestic areas of the villa, as well as hydrological structures (ornamental pond, water conduits, sewers, dykes, drains and aqueduct remains). This article presents an analysis of the hydrological structures discovered by geophysical survey, which were subsequently excavated, on the western side of the site between 315,94 m and 314,05 m above sea level. Within these structures (dyke, palaeochannel and sections of aqueduct) the most important element is an aqueduct that cannot be directly associated with the supply of water to the residential and agricultural parts of the villa upstream. The presence of this structure, which is characterised by a substantial slope, required the construction of a substantial foundation wall. Therefore, this structure could have been associated with the water supply to one of the adjacent buildings whose characteristics still need to be ascertained.Une fouille archéologique programmée, entreprise de 1998 à 2003 sur le site antique de Richeaume I (Puyloubier, Bouches-du-Rhône), a révélé la présence d'une vaste villa de plus de 5 000 m2 occupée du Ier s. av. J.-C. au début du VIe s. apr. J.-C., alimentée par un aqueduc captant les eaux de source au nord et entourée d'un certain nombre d'établissements ruraux souvent hérités du second âge du Fer. Les vestiges archéologiques mis au jour sur une superficie de 2 000 m2 correspondent aux parties résidentielle et agricole de la villa du Haut-Empire et de l'Antiquité tardive ainsi qu'à divers aménagements hydrauliques : bassins d'agrément, canalisations, égouts, murs de digue, drains et vestiges d'aqueducs. L'étude proposée ici porte sur les structures hydrauliques découvertes par la prospection géophysique et les fouilles archéologiques sur le versant oriental du site entre 315,94 et 314,05 m d'altitude. Parmi ces structures (mur de digue, paléochenal, tronçons d'aqueduc) se distinguent plus particulièrement les vestiges d'un aqueduc qui ne peut être mis en relation avec l'alimentation en eau des parties résidentielle et agricole de la villa situées plus en amont. Cet ouvrage, dont la pente à forte déclivité a nécessité la construction d'une imposante substruction, pourrait être associé à l'alimentation en eau d'un des bâtiments voisins dont la nature reste à définir

Les Écrins, un territoire d’altitude dans le contexte des Alpes occidentales de la Préhistoire récente à l’âge du Bronze (Hautes-Alpes, France)

Les premiers témoignages d’une présence humaine en altitude reconnus dans les Alpes méridionales françaises, dès la Préhistoire, s’inscrivent au sein de travaux pluridisciplinaires et diachroniques menés, depuis 1998, sur le peuplement et les activités humaines en moyenne et haute montagne. Développés plus particulièrement sur les hauts massifs de l’Argentiérois/Vallouise et du Champsaur dans le Parc National des Écrins (Hautes-Alpes), ces programmes corrèlent sur le terrain données archéologiques et paléoécologiques d’altitude. Dès la seconde moitié du iiie millénaire et au cours du iie millénaire BC (fin du Néolithique-âge du Bronze), se distinguent des structures bâties à vocation pastorale, entre 2 067 et 2 360 m d’altitude, en relation avec l’essor démographique observé dans les zones basses. L’occupation de la haute montagne durant cette période paraît continue et le milieu, exploité de manière durable.The earliest evidence for a prehistoric human presence identified in the Southern French Alps has been revealed by a multidisciplinary, diachronic research project that started in 1998. This research assesses the natural and social dynamics of occupation in the sub-alpine and alpine zones. This work is focussed on the high mountains of the Argentiérois/Vallouise and Champsaur areas in the Parc National des Écrins (Hautes-Alpes), and combines archaeological and palaeoenvironmental evidence. The second half of the IIIrd millennium BC and during the IInd millennium BC (the Late Neolithic and Bronze Age) is marked by the appearance of the built pastoral structures between 2067 and 2360m, related to the development and increase in populations at lower altitudes. This high altitude activity appears to be continuous and sustainable throughout these periods

Clinical impairment in premanifest and early Huntington's disease is associated with regionally specific atrophy.

TRACK-HD is a multicentre longitudinal observational study investigating the use of clinical assessments and 3-Tesla magnetic resonance imaging as potential biomarkers for future therapeutic trials in Huntington's disease (HD). The cross-sectional data from this large well-characterized dataset provide the opportunity to improve our knowledge of how the underlying neuropathology of HD may contribute to the clinical manifestations of the disease across the spectrum of premanifest (PreHD) and early HD. Two hundred and thirty nine gene-positive subjects (120 PreHD and 119 early HD) from the TRACK-HD study were included. Using voxel-based morphometry (VBM), grey and white matter volumes were correlated with performance in four domains: quantitative motor (tongue force, metronome tapping, and gait); oculomotor [anti-saccade error rate (ASE)]; cognition (negative emotion recognition, spot the change and the University of Pennsylvania smell identification test) and neuropsychiatric measures (apathy, affect and irritability). After adjusting for estimated disease severity, regionally specific associations between structural loss and task performance were found (familywise error corrected, P < 0.05); impairment in tongue force, metronome tapping and ASE were all associated with striatal loss. Additionally, tongue force deficits and ASE were associated with volume reduction in the occipital lobe. Impaired recognition of negative emotions was associated with volumetric reductions in the precuneus and cuneus. Our study reveals specific associations between atrophy and decline in a range of clinical modalities, demonstrating the utility of VBM correlation analysis for investigating these relationships in HD

Search for gravitational waves associated with the InterPlanetary Network short gamma ray bursts

We outline the scientific motivation behind a search for gravitational waves associated with short gamma ray bursts detected by the InterPlanetary Network (IPN) during LIGO's fifth science run and Virgo's first science run. The IPN localisation of short gamma ray bursts is limited to extended error boxes of different shapes and sizes and a search on these error boxes poses a series of challenges for data analysis. We will discuss these challenges and outline the methods to optimise the search over these error boxes.Comment: Methods paper; Proceedings for Eduardo Amaldi 9 Conference on Gravitational Waves, July 2011, Cardiff, U