Factors Associated with Revision Surgery after Internal Fixation of Hip Fractures

Background: Femoral neck fractures are associated with high rates of revision surgery after management with internal fixation. Using data from the Fixation using Alternative Implants for the Treatment of Hip fractures (FAITH) trial evaluating methods of internal fixation in patients with femoral neck fractures, we investigated associations between baseline and surgical factors and the need for revision surgery to promote healing, relieve pain, treat infection or improve function over 24 months postsurgery. Additionally, we investigated factors associated with (1) hardware removal and (2) implant exchange from cancellous screws (CS) or sliding hip screw (SHS) to total hip arthroplasty, hemiarthroplasty, or another internal fixation device. Methods: We identified 15 potential factors a priori that may be associated with revision surgery, 7 with hardware removal, and 14 with implant exchange. We used multivariable Cox proportional hazards analyses in our investigation. Results: Factors associated with increased risk of revision surgery included: female sex, [hazard ratio (HR) 1.79, 95% confidence interval (CI) 1.25-2.50; P = 0.001], higher body mass index (fo

Adventures in Organophosphorus Chemistry

Color poster with text and chemical models.Organophosphorus compounds have been an increasingly important part of organic synthesis since the discovery of the Arbuzov rearrangement in 1905. In the century that followed this discovery, the applications of phosphorus-based reagents in synthesis has grown to incorporate the Wittig and Horner-Wadsworth-Emmons reactions for alkene formation, as well as the Mitsunobu inversion reaction, which is used to convert alcohols to a wide range of products with inversion of configuration.Ronald E. McNair Post-baccalauerate Achivement Program; University of Wisconsin--Eau Claire Office of Research and Sponsored Program