Tunepal: Searching a Digital Library of Traditional Music Scores

Purpose – This paper aims to describe the Tunepal project as an example of a music information retrieval (MIR) system that is having an impact on how musicians access, learn and play traditional Irish music around the world. Design/methodology/approach – This paper describes the functionality of the Tunepal system: consisting of the tune corpus, the web site tunepal.org and mobile apps supporting iOS and Android OS. Tunepal facilitates query-by-title and query-by-playing music (QBP) searches and allows a musician to retrieve and playback scores amongst other supported functions. Findings – Tunepal has been favorably received and musicians report that the system is being used in a variety of scenarios including archiving and the preparation of sleeve notes for commercial recordings. Tunepal has a growing user base in 25 countries. Originality/value – The comprehensive tune corpus (over 16,000 compositions), the query-by-playing technology and the fact that the mobile apps provide access to the corpus in situ in traditional music sessions and classes make this project uniquely useful

A system for automatically annotating traditional Irish music field recordings

This paper presents MATT2 (Machine Annotation of Traditional Tunes). MATT2 is a novel system which can automatically annotate field recordings of traditional Irish music with useful metadata such as tune name, key signature, time signature, composer and discography. MATT2 works by using a number of algorithms to automatically transcribe digital audio to be annotated to the ABC music notation language. It then compares these transcriptions against a corpus of 860 human made transcriptions in ABC using a variation of the edit distance algorithm. Results using MATT2 to annotate fifty recordings of flute and fiddle tunes demonstrate a high success rate at annotating recordings made by different musicians. Additionally, several of the recordings successfully annotated in testing MATT2 were recorded in imperfect conditions, with badly degraded audio

Triangulum II: Not Especially Dense After All

Among the Milky Way satellites discovered in the past three years, Triangulum II has presented the most difficulty in revealing its dynamical status. Kirby et al. (2015a) identified it as the most dark matter-dominated galaxy known, with a mass-to-light ratio within the half-light radius of 3600 +3500 -2100 M_sun/L_sun. On the other hand, Martin et al. (2016) measured an outer velocity dispersion that is 3.5 +/- 2.1 times larger than the central velocity dispersion, suggesting that the system might not be in equilibrium. From new multi-epoch Keck/DEIMOS measurements of 13 member stars in Triangulum II, we constrain the velocity dispersion to be sigma_v < 3.4 km/s (90% C.L.). Our previous measurement of sigma_v, based on six stars, was inflated by the presence of a binary star with variable radial velocity. We find no evidence that the velocity dispersion increases with radius. The stars display a wide range of metallicities, indicating that Triangulum II retained supernova ejecta and therefore possesses or once possessed a massive dark matter halo. However, the detection of a metallicity dispersion hinges on the membership of the two most metal-rich stars. The stellar mass is lower than galaxies of similar mean stellar metallicity, which might indicate that Triangulum II is either a star cluster or a tidally stripped dwarf galaxy. Detailed abundances of one star show heavily depressed neutron-capture abundances, similar to stars in most other ultra-faint dwarf galaxies but unlike stars in globular clusters.Comment: accepted to ApJ, Table 5 available as a machine-readable table by clicking on "Other formats" on the right. Proof corrections reflected in version

Ethical considerations of telehealth: Access, inequity, trust, and overuse

In the U.S. healthcare system, telehealth is increasingly present and demands ethical assessment. On the one hand, telehealth increases access to healthcare services for some at-risk populations (e.g., people suffering from mental illness and addictions) and in specific contexts (e.g., rural). On the other hand, telehealth widens the digital divide and can lead to overuse of services. Furthermore, because it is still unclear how telehealth influences trust between patients and primary care clinicians, connecting relationship science and human communication research can inform critical reasoning. Finally, healthcare policy is advancing toward the wide adoption of telehealth. Hence, it is urgent to address these ethical issues and invest in further research

Modulation of plant autophagy during pathogen attack

In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens, regulating plant cell death, and antimicrobial defences. In turn, it appears that phytopathogens have evolved ways not only to evade autophagic clearance but also to modulate and co-opt autophagy for their own benefit. In this review, we summarize and discuss the emerging discoveries concerning how pathogens modulate both host and self-autophagy machineries to colonize their host plants, delving into the arms race that determines the fate of interorganismal interaction.Fil: Leary, Alexandre Y. Imperial College London; Reino UnidoFil: Sanguankiattichai, Nattapong. University of Oxford; Reino UnidoFil: Duggan, Cian. Imperial College London; Reino UnidoFil: Tumtas, Yasin. Imperial College London; Reino UnidoFil: Pandey, Pooja. Imperial College London; Reino UnidoFil: Segretin, Maria Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; ArgentinaFil: Salguero Linares, Jose. Imperial College London; Reino UnidoFil: Savage, Zachary D. Imperial College London; Reino UnidoFil: Yow, Rui Jin. Imperial College London; Reino UnidoFil: Bozkurt, Tolga O.. Imperial College London; Reino Unid

Supplementation With Multivitamins and Vitamin A and Incidence of Malaria Among HIV-Infected Tanzanian Women

Introduction: HIV and malaria infections occur in the same individuals, particularly in sub-Saharan Africa. We examined whether daily multivitamin supplementation (vitamins B complex, C, and E) or vitamin A supplementation altered malaria incidence in HIV-infected women of reproductive age. Methods: HIV-infected pregnant Tanzanian women recruited into the study were randomly assigned to daily multivitamins (B complex, C, and E), vitamin A alone, both multivitamins and vitamin A, or placebo. Women received malaria prophylaxis during pregnancy and were followed monthly during the prenatal and postpartum periods. Malaria was defined in 2 ways: presumptive diagnosis based on a physician's or nurse's clinical judgment, which in many cases led to laboratory investigations, and periodic examination of blood smears for malaria parasites. Results: Multivitamin supplementation compared with no multivitamins significantly lowered women's risk of presumptively diagnosed clinical malaria (relative risk: 0.78, 95% confidence interval: 0.67 to 0.92), although multivitamins increased their risk of any malaria parasitemia (relative risk: 1.24, 95% confidence interval: 1.02 to 1.50). Vitamin A supplementation did not change malaria incidence during the study. Conclusions: Multivitamin supplements have been previously shown to reduce HIV disease progression among HIV-infected women, and consistent with that, these supplements protected against development of symptomatic malaria. The clinical significance of increased risk of malaria parasitemia among supplemented women deserves further research, however. Preventive measures for malaria are warranted as part of an integrated approach to the care of HIV-infected individuals exposed to malaria

Pathogen manipulation of chloroplast function triggers a light-dependent immune recognition

In plants and animals, nucleotide-binding leucine-rich repeat (NLR) proteins are intracellular immune sensors that recognize and eliminate a wide range of invading pathogens. NLR-mediated immunity is known to be modulated by environmental factors. However, how pathogen recognition by NLRs is influenced by environmental factors such as light remains unclear. Here, we show that the agronomically important NLR Rpi-vnt1.1 requires light to confer disease resistance against races of the Irish potato famine pathogen Phytophthora infestans that secrete the effector protein AVRvnt1. The activation of Rpi-vnt1.1 requires a nuclear-encoded chloroplast protein, glycerate 3-kinase (GLYK), implicated in energy production. The pathogen effector AVRvnt1 binds the full-length chloroplast-targeted GLYK isoform leading to activation of Rpi-vnt1.1. In the dark, Rpi-vnt1.1-mediated resistance is compromised because plants produce a shorter GLYK-lacking the intact chloroplast transit peptide-that is not bound by AVRvnt1. The transition between full-length and shorter plant GLYK transcripts is controlled by a light-dependent alternative promoter selection mechanism. In plants that lack Rpi-vnt1.1, the presence of AVRvnt1 reduces GLYK accumulation in chloroplasts counteracting GLYK contribution to basal immunity. Our findings revealed that pathogen manipulation of chloroplast functions has resulted in a light-dependent immune response

An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

The molecular codes underpinning the functions of plant NLR immune receptors are poorly understood. We used in vitro Mu transposition to generate a random truncation library and identify the minimal functional region of NLRs. We applied this method to NRC4-a helper NLR that functions with multiple sensor NLRs within a Solanaceae receptor network. This revealed that the NRC4 N-terminal 29 amino acids are sufficient to induce hypersensitive cell death. This region is defined by the consensus MADAxVSFxVxKLxxLLxxEx (MADA motif) that is conserved at the N-termini of NRC family proteins and ~20% of coiled-coil (CC)-type plant NLRs. The MADA motif matches the N-terminal a1 helix of Arabidopsis NLR protein ZAR1, which undergoes a conformational switch during resistosome activation. Immunoassays revealed that the MADA motif is functionally conserved across NLRs from distantly related plant species. NRC-dependent sensor NLRs lack MADA sequences indicating that this motif has degenerated in sensor NLRs over evolutionary time