Clubs de lectura

El Club de Lectura de la UC3M está organizado por la Biblioteca y Espacio Estudiantes, y ofrece encuentros para grupos de entre ocho y dieciocho participantes. Los clubs de lectura de Getafe y Leganés están en su séptimo año y el de Colmenarejo, en el tercero. Ignacio J. Dufour, es socio fundador del Club de Lectura de Leganés-Getafe y del Club de Lectura de Colmenarejo.Contiene: Literatura al alcance de la mano (p.28) .-- Libros, autores y buen ambiente / Ignacio J. Dufour (p.29)

Shell Eco-marathon : diseño de la estructura de un prototipo destinado a participar en la Shell Eco-marathon Europe

La finalidad de este proyecto es el diseño de la estructura del prototipo que el equipo Shell Ecomarathon UC3M, perteneciente a la asociación Escudería UC3M de la Universidad Carlos III de Madrid, va emplear para participar en la próxima Shell Eco-marathon Europe [84], que se celebrará en mayo de 2014 en la ciudad de Rotterdam en los Países Bajos.Ingeniería Industria

Multi-locus barcoding confirms the occurrence of Elegant Tern in Western Europe

We are very grateful to the following people who helped in various ways with sample collection: Jérome Fuchs and Eric Pasquet (National Museum of Natural History, Paris), Sharon M. Birks (Burke Museum of Naturel History of Seattle), Charlotte Francesiaz, Benjamin Vollot and Gilles Balança (Sandwich Tern, France), Charles Collins (Elegant Tern, USA), Arnaud Lenoble (Royal Tern, Guadeloupe), Lorien Pichegru (Crested Tern, South Africa), Abdulmaula Hamza (Lesser Crested Tern, Libya) and Clive Barlow (The Gambia). Marcio Efe and Eli Bridge helped with genotyping and shared unpublished sequences. We thank Juan Antonio Gómez for advice and Miguel Chardí and Francisco Javier García-Gans for field assistance in Valencia (Spain). Mathias Grandpierre (Société pour l’Etude et l’Aménagement de la Nature dans le Sud-Ouest) helped with fieldwork at the Banc d’Arguin (France). All the experiments comply with the current laws of the country in which they were performed.Peer reviewedPostprin

Polytropic dark halos of elliptical galaxies

The kinematics of stars and planetary nebulae in early type galaxies provide vital clues to the enigmatic physics of their dark matter halos. We fit published data for fourteen such galaxies using a spherical, self-gravitating model with two components: (1) a Sersic stellar profile fixed according to photometric parameters, and (2) a polytropic dark matter halo that conforms consistently to the shared gravitational potential. The polytropic equation of state can describe extended theories of dark matter involving self-interaction, non-extensive thermostatistics, or boson condensation (in a classical limit). In such models, the flat-cored mass profiles widely observed in disc galaxies are due to innate dark physics, regardless of any baryonic agitation. One of the natural parameters of this scenario is the number of effective thermal degrees of freedom of dark matter (F_d) which is proportional to the dark heat capacity. By default we assume a cosmic ratio of baryonic and dark mass. Non-Sersic kinematic ideosyncrasies and possible non-sphericity thwart fitting in some cases. In all fourteen galaxies the fit with a polytropic dark halo improves or at least gives similar fits to the velocity dispersion profile, compared to a stars-only model. The good halo fits usually prefer F_d values from six to eight. This range complements the recently inferred limit of 7<F_d<10 (Saxton & Wu), derived from constraints on galaxy cluster core radii and black hole masses. However a degeneracy remains: radial orbital anisotropy or a depleted dark mass fraction could shift our models' preference towards lower F_d; whereas a loss of baryons would favour higher F_d.Comment: 17 pages, 10 figures, 2 tables. MNRAS accepte

Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

Background Non-alcoholic steatohepatitis (NASH) is a common type of chronic liver disease that can lead to cirrhosis. Obeticholic acid, a farnesoid X receptor agonist, has been shown to improve the histological features of NASH. Here we report results from a planned interim analysis of an ongoing, phase 3 study of obeticholic acid for NASH. Methods In this multicentre, randomised, double-blind, placebo-controlled study, adult patients with definite NASH,non-alcoholic fatty liver disease (NAFLD) activity score of at least 4, and fibrosis stages F2–F3, or F1 with at least oneaccompanying comorbidity, were randomly assigned using an interactive web response system in a 1:1:1 ratio to receive oral placebo, obeticholic acid 10 mg, or obeticholic acid 25 mg daily. Patients were excluded if cirrhosis, other chronic liver disease, elevated alcohol consumption, or confounding conditions were present. The primary endpointsfor the month-18 interim analysis were fibrosis improvement (≥1 stage) with no worsening of NASH, or NASH resolution with no worsening of fibrosis, with the study considered successful if either primary endpoint was met. Primary analyses were done by intention to treat, in patients with fibrosis stage F2–F3 who received at least one dose of treatment and reached, or would have reached, the month 18 visit by the prespecified interim analysis cutoff date. The study also evaluated other histological and biochemical markers of NASH and fibrosis, and safety. This study is ongoing, and registered with ClinicalTrials.gov, NCT02548351, and EudraCT, 20150-025601-6. Findings Between Dec 9, 2015, and Oct 26, 2018, 1968 patients with stage F1–F3 fibrosis were enrolled and received at least one dose of study treatment; 931 patients with stage F2–F3 fibrosis were included in the primary analysis (311 in the placebo group, 312 in the obeticholic acid 10 mg group, and 308 in the obeticholic acid 25 mg group). The fibrosis improvement endpoint was achieved by 37 (12%) patients in the placebo group, 55 (18%) in the obeticholic acid 10 mg group (p=0·045), and 71 (23%) in the obeticholic acid 25 mg group (p=0·0002). The NASH resolution endpoint was not met (25 [8%] patients in the placebo group, 35 [11%] in the obeticholic acid 10 mg group [p=0·18], and 36 [12%] in the obeticholic acid 25 mg group [p=0·13]). In the safety population (1968 patients with fibrosis stages F1–F3), the most common adverse event was pruritus (123 [19%] in the placebo group, 183 [28%] in the obeticholic acid 10 mg group, and 336 [51%] in the obeticholic acid 25 mg group); incidence was generally mild to moderate in severity. The overall safety profile was similar to that in previous studies, and incidence of serious adverse events was similar across treatment groups (75 [11%] patients in the placebo group, 72 [11%] in the obeticholic acid 10 mg group, and 93 [14%] in the obeticholic acid 25 mg group). Interpretation Obeticholic acid 25 mg significantly improved fibrosis and key components of NASH disease activity among patients with NASH. The results from this planned interim analysis show clinically significant histological improvement that is reasonably likely to predict clinical benefit. This study is ongoing to assess clinical outcomes

Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization.

The intestine harbors a large population of resident eosinophils, yet the function of intestinal eosinophils has not been explored. Flow cytometry and whole-mount imaging identified eosinophils residing in the lamina propria along the length of the intestine prior to postnatal microbial colonization. Microscopy, transcriptomic analysis, and mass spectrometry of intestinal tissue revealed villus blunting, altered extracellular matrix, decreased epithelial cell turnover, increased gastrointestinal motility, and decreased lipid absorption in eosinophil-deficient mice. Mechanistically, intestinal epithelial cells released IL-33 in a microbiota-dependent manner, which led to eosinophil activation. The colonization of germ-free mice demonstrated that eosinophil activation in response to microbes regulated villous size alterations, macrophage maturation, epithelial barrier integrity, and intestinal transit. Collectively, our findings demonstrate a critical role for eosinophils in facilitating the mutualistic interactions between the host and microbiota and provide a rationale for the functional significance of their early life recruitment in the small intestine

The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the SLC22 family.

Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response. Furthermore, influx transporters in organs such as the gut, liver and kidney may influence absorption, distribution, and elimination. Here, we analyzed 30 commonly used psychotropic drugs using a parallel artificial membrane permeability assay. Amisulpride and sulpiride showed the lowest membrane permeability (P e -6 cm/s) and will require influx transport to penetrate the blood-brain barrier and other physiological barriers. We then studied the uptake of amisulpride and sulpiride by the organic cation transporters of the SLC22 family OCT1, OCT2, OCT3, OCTN1, and OCTN2 Amisulpride was found to be transported by all five transporters studied. In contrast, sulpiride was only transported by OCT1 and OCT2. OCT1 showed the highest transport ability both for amisulpride (CLint = 1.9 ml/min/mg protein) and sulpiride (CLint = 4.2 ml/min/mg protein) and polymorphisms in OCT1 significantly reduced the uptake of both drugs. Furthermore, we observed carrier-mediated uptake that was inhibitable by known OCT inhibitors in the immortalized human brain microvascular endothelial cell line hCMEC/D3. In conclusion, this study demonstrates that amisulpride and sulpiride are substrates of organic cation transporters of the SLC22 family. SLC22 transporters may play an important role in the distribution of amisulpride and sulpiride, including their ability to penetrate the blood-brain barrier

Tidal Turbine Benchmarking Project: Stage I - Steady Flow Blind Predictions

International audienceThis paper presents the first blind prediction stage of the Tidal Turbine Benchmarking Project conducted and funded by the UK’s EPSRC and Supergen ORE Hub. In this first stage, only steady flow conditions, at low and elevated turbulence levels (3.1%), were considered. Prior to the blind prediction stage, a large laboratory-scale experiment was conducted in which a highly instrumented 1.6 m diameter tidal rotor was towed through a large towing tank in well-defined flow conditions with and without an upstream turbulence grid.Details of the test campaign and rotor design were released as part of this community blind prediction exercise. Participants were invited to simulate turbine performance and loads using appropriate methods. 26 submissions were received from 12 groups across academia and industry using techniques ranging from blade resolved Computational Fluid Dynamics through Actuator Line, Boundary Integral Equation Model, Vortex methods to engineering Blade Element Momentum methods.The comparisons between experiments and blind predictions were very positive, not only helping to provide validation and uncertainty estimates for the models, but also validating the experimental tests themselves. The exercise demonstrated that the experimental turbine data provides a robust dataset against which researchers and engineers can test their models and implementations, helping to reduce uncertainty and provide increased confidence in engineering processes, as well as a basis against which modellers can evaluate and refine approaches

Dynamic arterial elastance as a predictor of arterial pressure response to fluid administration: a validation study.

INTRODUCTION: Functional assessment of arterial load by dynamic arterial elastance (Eadyn), defined as the ratio between pulse pressure variation (PPV) and stroke volume variation (SVV), has recently been shown to predict the arterial pressure response to volume expansion (VE) in hypotensive, preload-dependent patients. However, because both SVV and PPV were obtained from pulse pressure analysis, a mathematical coupling factor could not be excluded. We therefore designed this study to confirm whether Eadyn, obtained from two independent signals, allows the prediction of arterial pressure response to VE in fluid-responsive patients. METHODS: We analyzed the response of arterial pressure to an intravenous infusion of 500 ml of normal saline in 53 mechanically ventilated patients with acute circulatory failure and preserved preload dependence. Eadyn was calculated as the simultaneous ratio between PPV (obtained from an arterial line) and SVV (obtained by esophageal Doppler imaging). A total of 80 fluid challenges were performed (median, 1.5 per patient; interquartile range, 1 to 2). Patients were classified according to the increase in mean arterial pressure (MAP) after fluid administration in pressure responders (≥ 10%) and non-responders. RESULTS: Thirty-three fluid challenges (41.2%) significantly increased MAP. At baseline, Eadyn was higher in pressure responders (1.04 ± 0.28 versus 0.60 ± 0.14; P < 0.0001). Preinfusion Eadyn was related to changes in MAP after fluid administration (R (2) = 0.60; P < 0.0001). At baseline, Eadyn predicted the arterial pressure increase to volume expansion (area under the receiver operating characteristic curve, 0.94; 95% confidence interval (CI): 0.86 to 0.98; P < 0.0001). A preinfusion Eadyn value ≥ 0.73 (gray zone: 0.72 to 0.88) discriminated pressure responder patients with a sensitivity of 90.9% (95% CI: 75.6 to 98.1%) and a specificity of 91.5% (95% CI: 79.6 to 97.6%). CONCLUSIONS: Functional assessment of arterial load by Eadyn, obtained from two independent signals, enabled the prediction of arterial pressure response to fluid administration in mechanically ventilated, preload-dependent patients with acute circulatory failure

Tidal Turbine Benchmarking Project:Stage I - Steady Flow Blind Predictions

This paper presents the first blind prediction stage of the Tidal Turbine Benchmarking Project being conducted and funded by the UK's EPSRC and Supergen ORE Hub. In this first stage, only steady flow conditions, at low and elevated turbulence (3.1%) levels, were considered. Prior to the blind prediction stage, a large laboratory scale experiment was conducted in which a highly instrumented 1.6m diameter tidal rotor was towed through a large towing tank in well-defined flow conditions with and without an upstream turbulence grid. Details of the test campaign and rotor design were released as part of this community blind prediction exercise. Participants were invited to use a range of engineering modelling approaches to simulate the performance and loads of the turbine. 26 submissions were received from 12 groups from across academia and industry using solution techniques ranging from blade resolved computational fluid dynamics through actuator line, boundary integral element methods, vortex methods to engineering Blade Element Momentum methods. The comparisons between experiments and blind predictions were extremely positive helping to provide validation and uncertainty estimates for the models, but also validating the experimental tests themselves. The exercise demonstrated that the experimental turbine data provides a robust data set against which researchers and design engineers can test their models and implementations to ensure robustness in their processes, helping to reduce uncertainty and provide increased confidence in engineering processes. Furthermore, the data set provides the basis by which modellers can evaluate and refine approaches