505 research outputs found

    Donald Davidson\u27s Semantics: Radical Interpretation, Triangulation, and the Ambiguity Problem

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    Donald Davidson was one of the most prominent philosophers of the 20th century. His work is extensive, dense, and controversial. This paper seeks to look at one part of Davidson’s philosophy: his philosophy of language, and in particular, his ideas about meaning. My first aim in this project is to present Davidson’s proposals about meaning as a unified meaning theory – a theory that can specify the meaning of any expression in a language. This theory contains two major parts: the proposal that a properly constrained truth theory can serve as a meaning theory, and the process of radical interpretation, by which one can in theory construct such a properly constrained truth theory based on purely behavioral evidence. My second aim is to add to the critical analysis of Davidson’s proposals. I do this by focusing on one particular issue that arises during the process of radical interpretation. During radical interpretation, certain ambiguities can arise for the interpreter that, if unresolved, would prove fatal to the project. I argue that we can resolve these ambiguities via Davidson’s own triangulation thesis – the idea that communication between two individuals is necessary for these speakers’ utterances to be meaningful. The communication provides a constraint on what a speaker can be taken to be talking about, or meaning, which resolves the problematic ambiguities. Finally, I seek to strengthen the position that triangulation can solve the ambiguity problem by defending it against three objections

    A Hedonic Analysis of the Value of Parks and Green Spaces in the Dublin Area [on housing market]. ESRI WP331. November 2009

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    We use a hedonic house price model to estimate the value of green spaces and parks to homeowners in the Dublin area. Using a dataset of house sales between 2001 and 2006 and combining it with available data on the location of green spaces in Dublin it is possible to assess the different values assigned to green areas by homeowners. We find that the value of green space depends first of all on how far from the property it is located. We also find a difference in the values assigned to open access parks and green spaces. For every 10% increase in the share of green space and park area near a house, its average price increases by 7% to 9%. We also attempted to identify different individual parks and rank them according to their value, however due to spatial multicollinearity the results were mixed

    A quantitative content analysis of UK newsprint coverage of proposed legislation to prohibit smoking in private vehicles carrying children

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    This project was funded by Cancer Research UK (MC_U130085862) and the Scottish School of Public Health Research. Cancer Research UK and the Scottish School of Public Health Research were not involved in the collection, analysis, and interpretation of data, writing of the manuscript or the decision to submit the manuscript for publication. Shona Hilton, Karen Wood and Chris Patterson were funded by the UK Medical Research Council as part of the Understandings and Uses of Public Health Research programme (MC_UU_12017/6) at the MRC/CSO Social and Public Health Sciences Unit, University of Glasgow. Thanks to Josh Bain and Alan Pollock for coding assistance.Peer reviewedPublisher PD

    Galactorrhea associated with juvenile systemic lupus erythematosus: a review of the role of prolactin

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    This case report is based on the clinical observation of a patient with juvenile systemic lupus erythematosus (SLE) who developed transient galactorrhea. The subsequent literature review documented an interesting association between prolactin and rheumatic diseases and in particular, hyperprolactinemia and SLE. The discussion that follows the case report explores this relationship and proposes a hypothesis regarding why this patient with juvenile SLE developed galactorrhea

    2014 Iowa Land Value Survey: Overview

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    This briefing paper includes background information on the Iowa land value survey, including historic information, an analysis of highest/lowest land values and changes from last year’s survey

    A Hedonic Analysis of the Value of Rail Transport in the Greater Dublin Area. ESRI WP264. November 2008

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    We use a hedonic house price model to estimate the value of transport networks to homeowners in the Dublin area. Using a dataset of house sales between 2001 and 2006 and combining it with available geographical information system data on the train and tram lines in Dublin, it is possible to assess the values assigned to different transport links by homeowners. We find that the value of transport depends on how far from the property it is located and is also affected by the availability of alternative transport options in the area. There are differences in the values assigned to recently constructed tramlines compared to the traditional rapid transit train stations. The study also takes into account house characteristics and other environmental amenities

    Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages

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    Abstract Background Interleukin-33 is a member of the IL-1 cytokine family whose functions are mediated and modulated by the ST2 receptor. IL-33-ST2 expression and interactions have been explored in mouse macrophages but little is known about the effect of IL-33 on human macrophages. The expression of ST2 transcript and protein levels, and IL-33-mediated effects on M1 (i.e. classical activation) and M2 (i.e. alternative activation) chemokine marker expression in human bone marrow-derived macrophages were examined. Results Human macrophages constitutively expressed the membrane-associated (i.e. ST2L) and the soluble (i.e. sST2) ST2 receptors. M2 (IL-4 + IL-13) skewing stimuli markedly increased the expression of ST2L, but neither polarizing cytokine treatment promoted the release of sST2 from these cells. When added to naïve macrophages alone, IL-33 directly enhanced the expression of CCL3. In combination with LPS, IL-33 blocked the expression of the M2 chemokine marker CCL18, but did not alter CCL3 expression in these naive cells. The addition of IL-33 to M1 macrophages markedly increased the expression of CCL18 above that detected in untreated M1 macrophages. Similarly, alternatively activated human macrophages treated with IL-33 exhibited enhanced expression of CCL18 and the M2 marker mannose receptor above that detected in M2 macrophages alone. Conclusions Together, these data suggest that primary responses to IL-33 in bone marrow derived human macrophages favors M1 chemokine generation while its addition to polarized human macrophages promotes or amplifies M2 chemokine expression.http://deepblue.lib.umich.edu/bitstream/2027.42/78250/1/1471-2172-11-52.xmlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78250/2/1471-2172-11-52.pdfPeer Reviewe
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