64 research outputs found
DPD Linearization Complexity Reduction of Remote Radio Heads in C-RAN with Radio over Fiber Fronthaul
Radio-over-Fiber (RoF) is a suitable technology for efficiently developing the cloud-RAN concept in Fifth Generation (5G) deployments based on Long Term Evolution Advanced LTE-A. Distortion coming out from the radiofrequency (RF) power amplifier should be taken into account in order to achieve the desired performance at the base station. In this paper, a complexity reduction technique based on a variable degree polynomial predistorter is proposed. The obtained results show that it is possible to achieve a reduction of operations with a penalty of 1.6 dB in ACLR and negligible impact on the EVM
Minimization of Feedback Loop Distortions in Digital Predistortion of a Radio-Over-Fiber System with Optimization Algorithms
This article proposes the linearization of an intensity modulation/direct detection radio-over-fiber (RoF) link with feedback loop. The goal is to carry out the predistortion process in a real scenario, in which the output signals are a few kilometers far from the baseband unit (BBU). First, the feedback loop is considered ideal, so the output signals are captured at the remote radio head side. Then, the feedback loop is taken into account, and both the input and output signals are captured at the BBU side. Applying optimization algorithms, such as Fibonacci, Golden, or Powell, it is possible to seek the optimal attenuation value within only a few iterations, which minimizes the distortion of the feedback loop. Experiments are carried out in a RoF system with 10 and 25 km length fiber within the long-Term evolution (LTE) standard. Measured results show how with a proper choice of the attenuation it is possible to reach analogous results regarding to an ideal feedback loop in terms of adjacent channel power ratio, the output signal power and error vector magnitude
Efficiency enhancement by reconfigurable matching networks in LINC transmitters
This paper proposes the use of a transmitter based on a linear amplification with nonlinear components (LINC) architecture, in which the reconfigurable matching networks (RMNs) are included. By varying the RMN active cell number, it is possible to change the load impedance at the power amplifier (PA) output, improving the amplifier drain efficiency and therefore the efficiency of the whole system. A long-term evolution (LTE) downlink signal with a bandwidth of 1.4 MHz and a peak-to-average power ratio (PAPR) of 11.48 dB is applied in order to carry out the experiments. Results show that the use of the RMNs in a LINC architecture improves the efficiency at all tested frequencies, especially at 927 MHz reaching an enhancement of 36.50%. Regarding the distortion, the adjacent channel leakage ratio (ACLR) values increase in all cases, with an improvement of 3.5 dB at 958 MHz. Finally, in terms of error vector magnitude (EVM), the proposed architecture offers a value of 1.96% at 927 MHz
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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations
Meningiomas are the most common primary nervous system tumor. The tumor suppressor NF2 is disrupted in approximately half of meningiomas1 but the complete spectrum of genetic changes remains undefined. We performed whole-genome or whole-exome sequencing on 17 meningiomas and focused sequencing on an additional 48 tumors to identify and validate somatic genetic alterations. Most meningiomas exhibited simple genomes, with fewer mutations, rearrangements, and copy-number alterations than reported in other adult tumors. However, several meningiomas harbored more complex patterns of copy-number changes and rearrangements including one tumor with chromothripsis. We confirmed focal NF2 inactivation in 43% of tumors and found alterations in epigenetic modifiers among an additional 8% of tumors. A subset of meningiomas lacking NF2 alterations harbored recurrent oncogenic mutations in AKT1 (E17K) and SMO (W535L) and exhibited immunohistochemical evidence of activation of their pathways. These mutations were present in therapeutically challenging tumors of the skull base and higher grade. These results begin to define the spectrum of genetic alterations in meningiomas and identify potential therapeutic targets
First observations of separated atmospheric nu_mu and bar{nu-mu} events in the MINOS detector
The complete 5.4 kton MINOS far detector has been taking data since the beginning of August 2003 at a depth of 2070 meters water-equivalent in the Soudan mine, Minnesota. This paper presents the first MINOS observations of nuµ and [overline nu ]µ charged-current atmospheric neutrino interactions based on an exposure of 418 days. The ratio of upward- to downward-going events in the data is compared to the Monte Carlo expectation in the absence of neutrino oscillations, giving Rup/downdata/Rup/downMC=0.62-0.14+0.19(stat.)±0.02(sys.). An extended maximum likelihood analysis of the observed L/E distributions excludes the null hypothesis of no neutrino oscillations at the 98% confidence level. Using the curvature of the observed muons in the 1.3 T MINOS magnetic field nuµ and [overline nu ]µ interactions are separated. The ratio of [overline nu ]µ to nuµ events in the data is compared to the Monte Carlo expectation assuming neutrinos and antineutrinos oscillate in the same manner, giving R[overline nu ][sub mu]/nu[sub mu]data/R[overline nu ][sub mu]/nu[sub mu]MC=0.96-0.27+0.38(stat.)±0.15(sys.), where the errors are the statistical and systematic uncertainties. Although the statistics are limited, this is the first direct observation of atmospheric neutrino interactions separately for nuµ and [overline nu ]µ
Unique, dual-indexed sequencing adapters with UMIs effectively eliminate index cross-talk and significantly improve sensitivity of massively parallel sequencing
The impact of tumor profiling approaches and genomic data strategies for cancer precision medicine
Observation of Muon Neutrino Disappearance with the MINOS Detectors in the NuMI Neutrino Beam
This Letter reports results from the MINOS experiment based on its initial exposure to neutrinos from the Fermilab NuMI beam. The rates and energy spectra of charged current νμ interactions are compared in two detectors located along the beam axis at distances of 1 and 735 km. With 1.27×1020 120 GeV protons incident on the NuMI target, 215 events with energies below 30 GeV are observed at the Far Detector, compared to an expectation of 336±14 events. The data are consistent with νμ disappearance via oscillations with |Δm322|=2.74-0.26+0.44×10-3 eV2 and sin2(2θ23)>0.87 (68% C.L.)
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