ЧИСЛЕННОЕ МОДЕЛИРОВАНИЕ ХАРАКТЕРИСТИК ИСКРОВОГО РАЗРЯДА В ЖИДКОМ АЗОТЕ

In MHD approximation, a mathematical model of spark discharge in liquid nitrogen is worked out on the basis of data generalization pertaining to thermodynamical functions and mass-transfer coefficients in a wide parameter range. The results obtained are used for analysis of both integral and spatial-temporal discharge characteristics important for practical application.В магнитогидродинамическом приближении разработана математическая модель искрового разряда в жидком азоте на основании обобщения данных о термодинамических функциях и коэффициентах переноса вещества в широком диапазоне параметров. С использованием полученных результатов численного моделирования выполнен анализ важных для практического применения интегральных и пространственно-временных характеристик разряда.У магнітогідродинамічному наближенні розроблено математичну модель іскрового розряду в рідкому азоті на основі узагальнення даних про термодинамічні функції і коефіцієнти переносу речовини в широкому діапазоні параметрів. З використанням отриманих результатів чисельного моделювання виконано аналіз важливих для практичного використання інтегральних і просторово-часових характеристик розряду

A systematic approach to the use of digital art in the training of design and tourism specialists

The aim of the research is to conduct a systematic analysis of the impact of digital art on the training process of professionals in design and tourism within the context of contemporary economic and cultural dynamics. Methodology of the study encompasses literature review, empirical methods such as surveys and observations, exploration of practical experiences in digital technologies in design and tourism. A systematic analysis of world economic trends and their consequences for education and tourism were carried out. Applications of science art in the study of design are analyzed. The relevance of digital art and its applications in design are summarized. The conditions for the transformation of the design industry in the cybertopia paradigm are formulated. Scientific novelty implies the systematic categorization and generalization of modern approaches to employing digital art in professional training, alongside the development of strategies for integrating digital technologies into education. The modern design formula is proved and the urgency for developing its strategy for the design of tourist complexes is postulated. Conclusions of the research underscore the necessity of integrating digital art into education curricula in design and tourism to ensure the competitiveness of alumni at the job market. The importance of creating new teaching methodologies that foster the development of imaginative thinking and creative potential of future professionals is highlighted. From these findings, recommendations are given to enhance educational programs and the curriculum of "Architecture and design of tourist complexes" course was developed. The change of education due to digital civilization is postulated

WebQuest Technologies: Developing Communicative Sphere of Preschool Children with Down Syndrome

The article reveals the direction of remedial work, using the WebQuest as a means of developing communicative competence of the children with intellectual impairments in general and with Down syndrome in particular. Within the framework of the study of communicative competence of the children with Down syndrome, we have carried out a theoretical analysis of the literature of domestic and foreign scholars. Based on the analysis of literature sources, the structural components of the communicative sphere of senior preschool-age children with Down syndrome were identified and a diagnostic programme was developed. The study identified and described the peculiarities of the communicative sphere of the child with Down syndrome, namely: a low level of expressive speech, an insufficient level of interest in a joint activity, incomprehension of communication norms and incomprehension of cause-and-effect relationship in communicative situations. The aim of the forming experiment was to develop a methodology for enriching communicative competence of the senior preschool-age children with Down syndrome. The paper describes the specifics of the use of WebQuests for the formation of communication skills during a remedial and developmental process. "A Magic Forest" WebQuest technology, which was developed by us, includes tasks aimed at forming components of communicative competence, the lack of which was revealed during the ascertaining experiment, namely: the development of expressive speech, the development of interest in a joint activity, the development of an understanding of communication norms, understanding cause-and-effect relationship in communicative situations. The article presents the results of experimental verification of the effectiveness of the WebQuest technology in the development of communicative competence of the child with Down syndrome. Such a form of work as WebQuest actuates the cognitive activity of a child with intellectual impairments and makes a remedial and developmental process more effective, interesting, diverse, and modern

Социальное партнерство — фактор успешного развития академической библиотеки

Social partnership is recognized as one of the strategic directions of the library activities. The article analyses the experience of professional cooperation of the Branch of the State public scientific-technological library of the Siberian branch of the Russian Academy of Sciences (SPSTL SB RAS) with the organizations of different levels. The conducted research allowed to identify the main aspects of joint activities of the academic library with various institutions for the solution of practical problems. Classification of types of social partnership is proposed. It includes the following direcions: technology, content, organizational-methodological and socio-cultural. Technological aspect of partnership includes cooperation in the development and implementation of new software and hardware, tools and services, and technological processes in the library activities. Implementation of the content-type of cooperation is realized by combining the efforts of several organizations in the formation of information resources, websites and portals. The activities of the academic library for conducting information and training events for a particular audience can be attributed to organizational-methodological interaction. Social and cultural partnership includes the development of memorial libraries, thematic clubs and organization and conducting excursions. Each area of library interaction with individual organizations and institutions is supported by specific examples. The experience of the Branch of SPSTL SB RAS shows that by combining various types of social partnership the library achieves high results in its work.Социальное партнерство признается одним из стратегических направлений деятельности библиотеки. В статье проанализирован опыт профессионального сотрудничества Отделения Государственной публичной научно-технической библиотеки Сибирского отделения Российской академии наук (ГПНТБ СО РАН) с организациями разного уровня. Проведенное исследование позволило выявить основные аспекты совместной деятельности академической библиотеки с различными учреждениями для решения практических задач. Предложена классификация видов социального партнерства, включающая технологическое, контентное, организационно-методическое и социально-культурное направления. К технологическому виду партнерства относится сотрудничество по вопросам разработки и внедрения новых программно-технических средств и сервисов, технологических процессов в деятельность библиотеки. Путем объединения усилий нескольких организаций при формировании информационных ресурсов, веб-сайтов, порталов происходит реализация контентного вида сотрудничества. Деятельность академической библиотеки по проведению информационных и обучающих мероприятий для определенной аудитории можно отнести к организационно-методическому взаимодействию. Социально-культурное партнерство включает создание мемориальных библиотек, проведение экскурсий, развитие тематических клубов. Каждое направление взаимодействия библиотеки с отдельными организациями и учреждениями подкреплено конкретными примерами. Опыт Отделения ГПНТБ СО РАН показывает, что при сочетании различных видов социального партнерства библиотека достигает в работе высоких результатов

Итоги изучения информационного обеспечения научных организаций Сибирского региона, подведомственных ФАНО

The article offers the analysis of scientific resources provision for the Siberian region research institutions, members of the Federal Agency for Scientific Organizations (FASO Russia), the study being done in 2016. Identified were bottlenecks in the system of resources provision for Siberian research institutions and universities within the frameworks of grants of the Russian Foundation for Basic Research (RFBR) and the Russian Ministry of Education and Science. Presented is the data on provision by national and foreign information resources after the disintegration of the centralized library acquisitions system of the Russian Academy of Science, Siberian Branch. The level of the information resources provision is recognized insufficient. The authors identify future directions for the development of the newly emerging structure of the FASO organizations information provision system in the context of a competitive system of foreign e-resources subscriptions provision. The study concludes that under the conditions of the new type centralization of the resources provision process the system of subscription distributions has not been fully formed on regional and institutional levels.Представлены результаты анализа состояния обеспеченности научными ресурсами организаций Сибирского региона, подведомственных Федеральному агентству научных организаций (по данным 2016 г.). Выявлены проблемы организации процесса обеспечения ресурсами научных институтов и вузов Сибири за счёт грантов Российского фонда фундаментальных исследований и Министерства образования и науки РФ. Приведены данные об обеспеченности отечественными и зарубежными ресурсами (после разрушения системы централизованного комплектования) библиотечной системы Сибирского отделения Российской академии наук. Выявлена недостаточная обеспеченность зарубежными и отечественными ресурсами. Обозначены перспективы вновь складывающейся структуры информационного обеспечения научных организаций ФАНО в условиях развития конкурсной системы подписки на удалённый доступ к зарубежным ресурсам. Отмечено, что система подписки на региональном и ведомственном уровнях в настоящее время ещё не сложилась

Serine protease identification (in vitro) and molecular structure predictions (in silico) from a phytopathogenic fungus, Alternaria solani

Citation: Chandrasekaran, M., Chandrasekar, R., Sa, T., & Sathiyabama, M. (2014). Serine protease identification (in vitro) and molecular structure predictions (in silico) from a phytopathogenic fungus, Alternaria solani. Retrieved from http://krex.ksu.eduSerine proteases generally share a relatively high degree of sequence identity and play a major role in the diversity of biological processes. Here we focus on three-dimensional molecular architecture of serine proteases from Alernaria solani. The difference in flexibility of active binding pockets and electrostatic surface potential distribution of serine proteases in comparison with other fungal species is reported in this study. In this study we have purified a serine protease from the early blight pathogen, Alernaria solani. MALDI-TOF-MS/MS analysis revealed that protease produced by A. solani belongs to alkaline serine proteases. AsP is made up of 403 amino acid residues with molecular weight of 42.1kDa (Isoelectric point (pI)-6.51) and molecular formula C[subscript 1859]H[subscript 2930]N[subscript 516]O[subscript 595]S[subscript 4]. The follow-up research on the molecular structure prediction is used for assessing the quality of A. solani Protease (AsP). The AsP protein structure model was built based on its comparative homology with serine protease using the program, MODELER. AsP had 16 β-sheets and 10 α-helices, with Ser[superscript 350] (G347-G357), Asp[superscript 158] (D158-H169) and His[superscript 193] (H193-G203) in separate turn/coil structures. Biological metal binding region situated near the 6th-helix and His[superscript 193] residue is responsible for metal binding site. In addition, the calcium ion is coordinated by the carboxyl groups of Lys[superscript 84], Ile[superscript 85], Lys[superscript 86], Asp[superscript 87], Phe[superscript 88], Ala[superscript 89], Ala[superscript 90] (K84-A90) for first calcium (Ca[superscript 2+]) binding site and carbonyl oxygen atom of Lys[superscript 244], Gly[superscript 245], Arg[superscript 246], Thr[superscript 247], Lys[superscript 248], Lys[superscript 249], and Ala[superscript 250] (K244–A250), for second Ca[superscript 2+] binding site. Moreover, Ramachandran plot analysis of protein residues falling into most favored secondary structures were determined (83.3%). The predicted molecular 3D structural model was further verified using PROCHECK, ERRAT and VADAR servers to confirm the geometry and stereo-chemical parameters of the molecular structural design. The functional analysis of AsP 3D molecular structure predictions familiar in the current study may provide a new perspective in the understanding and identification of antifungal protease inhibitor designing

Genome Sequencing and Comparative Transcriptomics of the Model Entomopathogenic Fungi Metarhizium anisopliae and M. acridum

Metarhizium spp. are being used as environmentally friendly alternatives to chemical insecticides, as model systems for studying insect-fungus interactions, and as a resource of genes for biotechnology. We present a comparative analysis of the genome sequences of the broad-spectrum insect pathogen Metarhizium anisopliae and the acridid-specific M. acridum. Whole-genome analyses indicate that the genome structures of these two species are highly syntenic and suggest that the genus Metarhizium evolved from plant endophytes or pathogens. Both M. anisopliae and M. acridum have a strikingly larger proportion of genes encoding secreted proteins than other fungi, while ∼30% of these have no functionally characterized homologs, suggesting hitherto unsuspected interactions between fungal pathogens and insects. The analysis of transposase genes provided evidence of repeat-induced point mutations occurring in M. acridum but not in M. anisopliae. With the help of pathogen-host interaction gene database, ∼16% of Metarhizium genes were identified that are similar to experimentally verified genes involved in pathogenicity in other fungi, particularly plant pathogens. However, relative to M. acridum, M. anisopliae has evolved with many expanded gene families of proteases, chitinases, cytochrome P450s, polyketide synthases, and nonribosomal peptide synthetases for cuticle-degradation, detoxification, and toxin biosynthesis that may facilitate its ability to adapt to heterogenous environments. Transcriptional analysis of both fungi during early infection processes provided further insights into the genes and pathways involved in infectivity and specificity. Of particular note, M. acridum transcribed distinct G-protein coupled receptors on cuticles from locusts (the natural hosts) and cockroaches, whereas M. anisopliae transcribed the same receptor on both hosts. This study will facilitate the identification of virulence genes and the development of improved biocontrol strains with customized properties

On the solution of the Aleksidze problem

The nonlіnear boundary Alexіdze problem for Laplace’s equatіon postulates the gravіty analytіcal prolongatі on іn global areas. An algorіthm of іts solutіon іs poіnted out as a calculatіon of sіmple layer densіty from the Fred holm іntegral equatіon wіth the regularіzatіon of subіntegral derіvatіves of the dіsturbіng potentіal