401 research outputs found
Today's Children, Tomorrow's America: Six Experts Face the Facts
Compiles essays about trends in family structure; how federal, state, and local budget deficits and projected cuts affect child poverty rates and health; and their long-term implications of reduced investment in children. Includes policy recommendations
Using co-occurrence network structure to extract synonymous gene and protein names from MEDLINE abstracts
BACKGROUND: Text-mining can assist biomedical researchers in reducing information overload by extracting useful knowledge from large collections of text. We developed a novel text-mining method based on analyzing the network structure created by symbol co-occurrences as a way to extend the capabilities of knowledge extraction. The method was applied to the task of automatic gene and protein name synonym extraction. RESULTS: Performance was measured on a test set consisting of about 50,000 abstracts from one year of MEDLINE. Synonyms retrieved from curated genomics databases were used as a gold standard. The system obtained a maximum F-score of 22.21% (23.18% precision and 21.36% recall), with high efficiency in the use of seed pairs. CONCLUSION: The method performs comparably with other studied methods, does not rely on sophisticated named-entity recognition, and requires little initial seed knowledge
Effect of cytokine growth factors on the prevention of acute wound failure
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73237/1/j.1067-1927.2004.012109.x.pd
A simple model for the vibrational modes in honeycomb lattices
The classical lattice dynamics of honeycomb lattices is studied in the
harmonic approximation. Interactions between nearest neighbors are represented
by springs connecting them. A short and necessary introduction of the lattice
structure is presented. The dynamical matrix of the vibrational modes is then
derived, and its eigenvalue problem is solved analytically. The solution may
provide deeper insight into the nature of the vibrational modes. Numerical
results for the vibrational frequencies are presented. To show that how
effective our method used for the case of honeycomb lattice is, we also apply
it to triangular and square lattice structures. A few suggested problems are
listed in the concluding section.Comment: 9 pages, 12 figures, submitted to American Journal of Physic
Electron-Phonon Scattering in Metallic Single-Walled Carbon Nanotubes
Electron scattering rates in metallic single-walled carbon nanotubes are
studied using an atomic force microscope as an electrical probe. From the
scaling of the resistance of the same nanotube with length in the low and high
bias regimes, the mean free paths for both regimes are inferred. The observed
scattering rates are consistent with calculations for acoustic phonon
scattering at low biases and zone boundary/optical phonon scattering at high
biases.Comment: 4 pages, 5 figure
Phonon and plasmon excitation in inelastic electron tunneling spectroscopy of graphite
The inelastic electron tunneling spectrum (IETS)of highly oriented pyrolitic
graphite (HOPG) has been measured with scanning tunneling spectroscopy (STS) at
6K. The observed spectral features are in very good agreement with the
vibrational density of states (vDOS) of graphite calculated from first
principles. We discuss the enhancement of certain phonon modes by
phonon-assisted tunneling in STS based on the restrictions imposed by the
electronic structure of graphite. We also demonstrate for the first time the
local excitation of surface-plasmons in IETS which are detected at an energy of
40 meV.Comment: PRB rapid communication, submitte
Risk Factors for Urinary Complications After Renal Transplantation
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73788/1/j.1600-6143.2007.01790.x.pd
The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus
Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. This article reviews the evidence for the involvement of chemokine receptors in FIV infection and contrasts these findings with similar studies on the primate lentiviruses HIV and SIV (simian immunodeficiency virus)
Studying the local character of Raman features of single-walled carbon nanotubes along a bundle using TERS
Here, we show that the Raman intensity of the G-mode in tip-enhanced Raman spectroscopy (TERS) is strongly dependent on the height of the bundle. Moreover, using TERS we are able to position different single-walled carbon nanotubes along a bundle, by correlating the observed radial breathing mode (RBM) with the AFM topography at the measuring point. The frequency of the G- mode behaves differently in TERS as compared to far-field Raman. Using the RBM frequency, the diameters of the tubes were calculated and a very good agreement with the G--mode frequency was observed
Amine functionalization of cholecyst-derived extracellular matrix with generation 1 PAMAM dendrimer
This document is the unedited author's version of a Submitted Work that was subsequently accepted for publication in Biomacromolecules, copyright © American Chemical Society after peer review. To access the final edited and published work, see http://pubs.acs.org/doi/pdf/10.1021/bm701055k.A method to functionalize cholecyst-derived extracellular matrix (CEM) with free amine groups was established in an attempt to improve its potential for tethering of bioactive molecules. CEM was incorporated with Generation-1 polyamidoamine (G1 PAMAM) dendrimer by using N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide and N-hydroxysuccinimide cross-linking system. The nature of incorporation of PAMAM dendrimer was evaluated using shrink temperature measurements, Fourier transform infrared (FTIR) assessment, ninhydrin assay, and swellability. The effects of PAMAM incorporation on mechanical and degradation properties of CEM were evaluated using a uniaxial mechanical test and collagenase degradation assay, respectively. Ninhydrin assay and FTIR assessment confirmed the presence of increasing free amine groups with increasing quantity of PAMAM in dendrimer-incorporated CEM (DENCEM) scaffolds. The amount of dendrimer used was found to be critical in controlling scaffold degradation, shrink temperature, and free amine content. Cell culture studies showed that fibroblasts seeded on DENCEM maintained their metabolic activity and ability to proliferate in vitro. In addition, fluorescence cell staining and scanning electron microscopy analysis of cell-seeded DENCEM showed preservation of normal fibroblast morphology and phenotype
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