Application of Artificial Fish Swarm Algorithm in Radial Basis Function Neural Network

Neural network is one of the branches with the most active research, development and application in computational intelligence and machine study. Radial basis function neural network (RBFNN) has achieved some success in more than one application field, especially in pattern recognition and functional approximation. Due to its simple structure, fast training speed and excellent generalization ability, it has been widely used. Artificial fish swarm algorithm (AFSA) is a new swarm intelligent optimization algorithm derived from the study on the preying behavior of fish swarm. This algorithm is not sensitive to the initial value and the parameter selection, but strong in robustness and simple and easy to realize and it also has parallel processing capability and global searching ability. This paper mainly researches the weight and threshold of AFSA in optimizing RBFNN. The simulation experiment proves that AFSA-RBFNN is significantly advantageous in global optimization capability and that it has outstanding global optimization ability and stability

Numerical integration of stochastic contact Hamiltonian systems via stochastic Herglotz variational principle

In this work we construct a stochastic contact variational integrator and its discrete version via stochastic Herglotz variational principle for stochastic contact Hamiltonian systems. A general structure-preserving stochastic contact method is devised, and the stochastic contact variational integrators are established. The implementation of this approach is validated by the numerical experiments.Comment: 24 pages,15 figure

HSV-1 miR-H6 Inhibits HSV-1 Replication and IL-6 Expression in Human Corneal Epithelial Cells In Vitro

HSV-1 infection in the cornea could lead to blindness. The infected cell polypeptide 4 (ICP4) of herpes simplex virus 1 (HSV-1) is a regulator of viral transcription that is required for productive infection. It has been previously demonstrated that miR-H6 encoded from HSV-1 genome targets ICP4 to help maintain latency. In this study, synthesized miR-H6 mimics were transfected into HSV-1-infected human cornea epithelial (HCE) cells. The inhibition of HSV-1 replication and viral ICP4 expression in miR-H6-transfected HCE was confirmed by plaque assay, immunofluorescence, and Western blot. Compared to nontransfection or mock, miR-H6 produced a low-titer HSV-1 and weak ICP4 expression. In addition, miR-H6 can decrease the interleukin 6 released into the medium, which was determined by ELISA. Taken together, the data suggests that miR-H6 targeting of ICP4 inhibits HSV-1 productive infection and decreases interleukin 6 production in HCE, and this may provide an approach to prevent HSV-1 lytic infection and inhibit corneal inflammation

Random Dynamics of the Stochastic Boussinesq Equations Driven by Lévy Noises

This paper is devoted to the investigation of random dynamics of the stochastic Boussinesq equations driven by Lévy noise. Some fundamental properties of a subordinator Lévy process and the stochastic integral with respect to a Lévy process are discussed, and then the existence, uniqueness, regularity, and the random dynamical system generated by the stochastic Boussinesq equations are established. Finally, some discussions on the global weak solution of the stochastic Boussinesq equations driven by general Lévy noise are also presented

Vectorial structure of a hard-edged-diffracted four-petal Gaussian beam in the far field

Based on the vector angular spectrum method and the stationary phase method and the fact that a circular aperture function can be expanded into a finite sum of complex Gaussian functions, the analytical vectorial structure of a four-petal Gaussian beam (FPGB) diffracted by a circular aperture is derived in the far field. The energy flux distributions and the diffraction effect introduced by the aperture are studied and illustrated graphically. Moreover, the influence of the f-parameter and the truncation parameter on the nonparaxiality is demonstrated in detail. In addition, the analytical formulas obtained in this paper can degenerate into un-apertured case when the truncation parameter tends to infinity. This work is beneficial to strengthen the understanding of vectorial properties of the FPGB diffracted by a circular aperture

Analytical vectorial structure of non-paraxial four-petal Gaussian beams in the far field

The analytical vectorial structure of non-paraxial four-petal Gaussian beams(FPGBs) in the far field has been studied based on vector angular spectrum method and stationary phase method. In terms of analytical electromagnetic representations of the TE and TM terms, the energy flux distributions of the TE term, the TM term, and the whole beam are derived in the far field, respectively. According to our investigation, the FPGBs can evolve into a number of small petals in the far field. The number of the petals is determined by the order of input beam. The physical pictures of the FPGBs are well illustrated from the vectorial structure, which is beneficial to strengthen the understanding of vectorial properties of the FPGBs

Evaluation of the Ribosomal Protein S1 Gene (rpsA) as a Novel Biomarker for Mycobacterium Species Identification

Objectives. To evaluate the resolution and reliability of the rpsA gene, encoding ribosomal protein S1, as a novel biomarker for mycobacteria species identification. Methods. A segment of the rpsA gene (565 bp) was amplified by PCR from 42 mycobacterial reference strains, 172 nontuberculosis mycobacteria clinical isolates, and 16 M. tuberculosis complex clinical isolates. The PCR products were sequenced and aligned by using the multiple alignment algorithm in the MegAlign package (DNASTAR) and the MEGA program. A phylogenetic tree was constructed by the neighbor-joining method. Results. Comparative sequence analysis of the rpsA gene provided the basis for species differentiation within the genus Mycobacterium. Slow-and rapid-growing groups of mycobacteria were clearly separated, and each mycobacterial species was differentiated as a distinct entity in the phylogenetic tree. The sequences discrepancy was obvious between M. kansasii and M. gastri, M. chelonae and M. abscessus, M. avium and M. intracellulare, and M. szulgai and M. malmoense, which cannot be achieved by 16S ribosomal DNA (rDNA) homologue genes comparison. 183 of the 188 (97.3%) clinical isolates, consisting of 8 mycobacterial species, were identified correctly by rpsA gene blast. Conclusions. Our study indicates that rpsA sequencing can be used effectively for mycobacteria species identification as a supplement to 16S rDNA sequence analysis

Right upper lobe segmentectomy and subsegmentectomy guided by classification pattern of peripheral segmental veins

BackgroundStudies have analyzed the simplified branching pattern of peripheral segmental veins and developed a standardized approach for intersegmental vein identification in the right upper lobe (RUL). However, the identification approach of intersubsegmental veins has not been reported. This study aimed to supplement the identification approach of intersubsegmental veins and the classification pattern of peripheral segmental veins by using three-dimensional computed tomography bronchography and angiography (3D-CTBA).Materials and methodsA total of 600 patients with ground glass opacity (GGO) who had undergone 3D-CTBA preoperatively at Hebei General Hospital between September 2020 and September 2022 were used for the retrospective study. We reviewed the anatomical variations of RUL veins in these patients using 3D-CTBA images.ResultsAccording to the anatomical position, the peripheral segmental veins structures of RUL were classified into five categories: “Iab type of anterior with central vein” (256/600, 42.7%), “Ib type of anterior with central vein” (166/600, 27.7%), “Central vein type” (38/600, 6.3%), “Anterior vein type” (81/600, 13.5%), “Right top pulmonary vein type” (57/600, 9.5%). The approach for intersegmental vein and intersubsegmental veins identification was divided into five types: anterior approach, posterobronchial approach, central vein approach, V2t approach, and intermediate bronchus posterior surface approach.ConclusionsThe classification pattern of peripheral segmental veins should find wide application. Further, approaches identifying intersegmental veins and intersubsegmental veins may help thoracic surgeons perform safe and accurate RUL segmentectomy

Mink is a highly susceptible host species to circulating human and avian influenza viruses

Pandemic influenza, typically caused by reassortment of human and avian influenza viruses, can result in severe or fatal infections in humans. Timely identification of potential pandemic viruses must be a priority in influenza virus surveillance. However, the range of host species responsible for the generation of novel pandemic influenza viruses remain unclear. In this study, we conducted serological surveys for avian and human influenza virus infections in farmed mink and determined the susceptibility of mink to prevailing avian and human virus subtypes. The results showed that farmed mink were commonly infected with human (H3N2 and H1N1/pdm) and avian (H7N9, H5N6, and H9N2) influenza A viruses. Correlational analysis indicated that transmission of human influenza viruses occurred from humans to mink, and that feed source was a probable route of avian influenza virus transmission to farmed mink. Animal experiments showed that mink were susceptible and permissive to circulating avian and human influenza viruses, and that human influenza viruses (H3N2 and H1N1/pdm), but not avian viruses, were capable of aerosol transmission among mink. These results indicate that farmed mink could be highly permissive “mixing vessels” for the reassortment of circulating human and avian influenza viruses. Therefore, to reduce the risk of emergence of novel pandemic viruses, feeding mink with raw poultry by-products should not be permitted, and epidemiological surveillance of influenza viruses in mink farms should be urgently implemented