In which shell-type SNRs should we look for gamma-rays and neutrinos from p-p collisions?

We present a simple analytic model for the various contributions to the non-thermal emission from shell type SNRs, and show that this model's results reproduce well the results of previous detailed calculations. We show that the \geq 1 TeV gamma ray emission from the shell type SNRs RX J1713.7-3946 and RX J0852.0-4622 is dominated by inverse-Compton scattering of CMB photons (and possibly infra-red ambient photons) by accelerated electrons. Pion decay (due to proton-proton collisions) is shown to account for only a small fraction, \lesssim10^-2, of the observed flux, as assuming a larger fractional contribution would imply nonthermal radio and X-ray synchrotron emission and thermal X-ray Bremsstrahlung emission that far exceed the observed radio and X-ray fluxes. Models where pion decay dominates the \geq 1 TeV flux avoid the implied excessive synchrotron emission (but not the implied excessive thermal X-ray Bremsstrahlung emission) by assuming an extremely low efficiency of electron acceleration, K_ep \lesssim 10^-4 (K_ep is the ratio of the number of accelerated electrons and the number of accelerated protons at a given energy). We argue that observations of SNRs in nearby galaxies imply a lower limit of K_ep \gtrsim 10^-3, and thus rule out K_ep values \lesssim 10^-4 (assuming that SNRs share a common typical value of K_ep). It is suggested that SNRs with strong thermal X-ray emission, rather than strong non-thermal X-ray emission, are more suitable candidates for searches of gamma rays and neutrinos resulting from proton-proton collisions. In particular, it is shown that the neutrino flux from the SNRs above is probably too low to be detected by current and planned neutrino observatories (Abridged).Comment: 13 pages, 1 figure, accepted for publication in JCAP, minor revision

Modeling the power flow in normal conductor-insulator-superconductor junctions

Normal conductor-insulator-superconductor (NIS) junctions promise to be interesting for x-ray and phonon sensing applications, in particular due to the expected self-cooling of the N electrode by the tunneling current. Such cooling would enable the operation of the active element of the sensor below the cryostat temperature and at a correspondingly higher sensitivity. It would also allow the use of MS junctions as microcoolers. At present, this cooling has not been realized in large area junctions (suitable for a number of detector applications). In this article, we discuss a detailed modeling of the heat flow in such junctions; we show how the heat flow into the normal electrode by quasiparticle back-tunneling and phonon absorption from quasiparticle pair recombination can overcompensate the cooling power. This provides a microscopic explanation of the self-heating effects we observe in our large area NIS junctions. The model suggests a number of possible solutions

Population III Generated Cosmic Rays and the Production of Li6

We calculate the evolution of Li6 generated from cosmic rays produced by an early population of massive stars. The computation is performed in the framework of hierarchical structure formation and is based on cosmic star formation histories constrained to reproduce the observed star formation rate at redshift z \la 6, the observed chemical abundances in damped Lyman alpha absorbers and in the intergalactic medium, and to allow for an early reionization of the Universe at z\sim 11 by Pop III stars as indicated by the third year results released by WMAP. We show that the pregalactic production of the Li6 isotope in the IGM via these Pop III stars can account for the Li6 plateau observed in metal poor halo stars without additional over-production of Li7. Our results depend on the efficiency of cosmic rays to propagate out of minihalos and the fraction of supernovae energy deposited in cosmic rays. We also compute the cosmic ray heating of the IGM gas. In general, we find somewhat high temperatures (of order 10^5 K) implying that the cosmic rays production of Li6 may be required to be confined to the so-called warm-hot IGM.Comment: 9 pages 8 figure

Nonlinear shock acceleration beyond the Bohm limit

We suggest a physical mechanism whereby the acceleration time of cosmic rays by shock waves can be significantly reduced. This creates the possibility of particle acceleration beyond the knee energy at ~10^15eV. The acceleration results from a nonlinear modification of the flow ahead of the shock supported by particles already accelerated to the knee momentum at p ~ p_*. The particles gain energy by bouncing off converging magnetic irregularities frozen into the flow in the shock precursor and not so much by re-crossing the shock itself. The acceleration rate is thus determined by the gradient of the flow velocity and turns out to be formally independent of the particle mean free path (m.f.p.). The velocity gradient is, in turn, set by the knee-particles at p ~ p_* as having the dominant contribution to the CR pressure. Since it is independent of the m.f.p., the acceleration rate of particles above the knee does not decrease with energy, unlike in the linear acceleration regime. The reason for the knee formation at p ~ p_* is that particles with $p > p_*$ are effectively confined to the shock precursor only while they are within limited domains in the momentum space, while other particles fall into ``loss-islands'', similar to the ``loss-cone'' of magnetic traps. This structure of the momentum space is due to the character of the scattering magnetic irregularities. They are formed by a train of shock waves that naturally emerge from unstably growing and steepening magnetosonic waves or as a result of acoustic instability of the CR precursor. These losses steepen the spectrum above the knee, which also prevents the shock width from increasing with the maximum particle energy.Comment: aastex, 13 eps figure

Upregulation of CD36, a Fatty Acid Translocase, Promotes Colorectal Cancer Metastasis by Increasing MMP28 and Decreasing E-Cadherin Expression

Altered fatty acid metabolism continues to be an attractive target for therapeutic intervention in cancer. We previously found that colorectal cancer (CRC) cells with a higher metastatic potential express a higher level of fatty acid translocase (CD36). However, the role of CD36 in CRC metastasis has not been studied. Here, we demonstrate that high expression of CD36 promotes invasion of CRC cells. Consistently, CD36 promoted lung metastasis in the tail vein model and GI metastasis in the cecum injection model. RNA-Seq analysis of CRC cells with altered expression of CD36 revealed an association between high expression of CD36 and upregulation of MMP28, a novel member of the metallopeptidase family of proteins. Using shRNA-mediated knockdown and overexpression of CD36, we confirmed that CD36 regulates MMP28 expression in CRC cells. siRNA-mediated knockdown of MMP28 decreases invasion of CRC cells, suggesting that MMP28 regulates the metastatic properties of cells downstream of CD36. Importantly, high expression of MMP28 leads to a significant decrease in active E-cadherin and an increase in the products of E-cadherin cleavage, CTF1 and CTF2. In summary, upregulation of CD36 expression promotes the metastatic properties of CRC via upregulation of MMP28 and an increase in E-cadherin cleavage, suggesting that targeting the CD36–MMP28 axis may be an effective therapeutic strategy for CRC metastasis

Shock Acceleration of Cosmic Rays - a critical review

Motivated by recent unsuccessful efforts to detect the predicted flux of TeV gamma-rays from supernova remnants, we present a critical examination of the theory on which these predictions are based. Three crucial problems are identified: injection, maximum achievable particle energy and spectral index. In each case significant new advances in understanding have been achieved, which cast doubt on prevailing paradigms such as Bohm diffusion and single-fluid MHD. This indicates that more realistic analytical models, backed by more sophisticated numerical techniques should be employed to obtain reliable predictions. Preliminary work on incorporating the effects of anomalous transport suggest that the resulting spectrum should be significantly softer than that predicted by conventional theory.Comment: 8 pages, invited review presented at the 17th ECRS, Lodz, July 2000; to appear in Journal of Physics G: Nuclear and Particle Physic

A field study of team working in a new human supervisory control system

This paper presents a case study of an investigation into team behaviour in an energy distribution company. The main aim was to investigate the impact of major changes in the company on system performance, comprising human and technical elements. A socio-technical systems approach was adopted. There were main differences between the teams investigated in the study: the time of year each control room was studied (i.e. summer or winter),the stage of development each team was in (i.e. 10 months), and the team structure (i.e. hierarchical or heterarchical). In all other respects the control rooms were the same: employing the same technology and within the same organization. The main findings were: the teams studied in the winter months were engaged in more `planning’ and `awareness’ type of activities than those studies in the summer months. Newer teams seem to be engaged in more sharing of information than older teams, which maybe indicative of the development process. One of the hierarchical teams was engaged in more `system-driven’ activities than the heterarchical team studied at the same time of year. Finally, in general, the heterarchical team perceived a greater degree of team working culture than its hierarchical counterparts. This applied research project confirms findings from laboratory research and emphasizes the importance of involving ergonomics in the design of team working in human supervisory control

Simulating cosmic rays in clusters of galaxies - II. A unified scheme for radio halos and relics with predictions of the gamma-ray emission

The thermal plasma of galaxy clusters lost most of its information on how structure formation proceeded as a result of dissipative processes. In contrast, non-equilibrium distributions of cosmic rays (CR) preserve the information about their injection and transport processes and provide thus a unique window of current and past structure formation processes. This information can be unveiled by observations of non-thermal radiative processes, including radio synchrotron, hard X-ray, and gamma-ray emission. To explore this, we use high-resolution simulations of a sample of galaxy clusters spanning a mass range of about two orders of magnitudes, and follow self-consistent CR physics on top of the radiative hydrodynamics. We model CR electrons that are accelerated at cosmological structure formation shocks and those that are produced in hadronic interactions of CRs with ambient gas protons. We find that CR protons trace the time integrated non-equilibrium activities of clusters while shock-accelerated CR electrons probe current accretion and merging shock waves. The resulting inhomogeneous synchrotron emission matches the properties of observed radio relics. We propose a unified model for the generation of radio halos. Giant radio halos are dominated in the centre by secondary synchrotron emission with a transition to the synchrotron radiation emitted from shock-accelerated electrons in the cluster periphery. This model is able to explain the observed correlation of mergers with radio halos, the larger peripheral variation of the spectral index, and the large scatter in the scaling relation between cluster mass and synchrotron emission. Future low-frequency radio telescopes (LOFAR, GMRT, MWA, LWA) are expected to probe the accretion shocks of clusters. [abridged]Comment: 32 pages, 19 figures, small changes to match the version to be published by MNRAS, full resolution version available at http://www.cita.utoronto.ca/~pfrommer/Publications/CRs_non-thermal.pd

A Compton-vetoed germanium detector with increased sensitivity at low energies

The difficulty to directly detect plutonium in spent nuclear fuel due to the high Compton background of the fission products motivates the design of a Gamma detector with improved sensitivity at low energies. We have built such a detector by operating a thin high-purity Ge detector with a large scintillator Compton veto directly behind it. The Ge detector is thin to absorb just the low-energy Pu radiation of interest while minimizing Compton scattering of high energy radiation from the fission products. The subsequent scintillator is large so that forward scattered photons from the Ge detector interact in it at least once to provide an anti-coincidence veto for the Ge detector. For highest sensitivity, additional material in the line-of-sight is minimized, the radioactive sample is kept thin, and its radiation is collimated. We will discuss the instrument design, and demonstrate the feasibility of the approach with a prototype that employs two large CsI scintillator vetoes. Initial spectra of a thin Cs-137 calibration source show a background suppression of a factor of {approx}2.5 at {approx}100 keV, limited by an unexpectedly thick 4 mm dead layer in the Ge detector

105110^{51} Ergs: The Evolution of Shell Supernova Remnants

This paper reports on a workshop hosted by the University of Minnesota, March 23-26, 1997. It addressed fundamental dynamical issues associated with the evolution of shell supernova remnants and the relationships between supernova remnants and their environments. The workshop considered, in addition to classical shell SNRs, dynamical issues involving X-ray filled composite remnants and pulsar driven shells, such as that in the Crab Nebula. Approximately 75 participants with wide ranging interests attended the workshop. An even larger community helped through extensive on-line debates prior to the meeting. Each of the several sessions, organized mostly around chronological labels, also addressed some underlying, general physical themes: How are SNR dynamics and structures modified by the character of the CSM and the ISM and vice versa? How are magnetic fields generated in SNRs and how do magnetic fields influence SNRs? Where and how are cosmic-rays (electrons and ions) produced in SNRs and how does their presence influence or reveal SNR dynamics? How does SNR blast energy partition into various components over time and what controls conversion between components? In lieu of a proceedings volume, we present here a synopsis of the workshop in the form of brief summaries of the workshop sessions. The sharpest impressions from the workshop were the crucial and under-appreciated roles that environments have on SNR appearance and dynamics and the critical need for broad-based studies to understand these beautiful, but enigmatic objects. \\Comment: 54 pages text, no figures, Latex (aasms4.sty). submitted to the PAS