225 research outputs found
Bose-Einstein condensate collapse: a comparison between theory and experiment
We solve the Gross-Pitaevskii equation numerically for the collapse induced
by a switch from positive to negative scattering lengths. We compare our
results with experiments performed at JILA with Bose-Einstein condensates of
Rb-85, in which the scattering length was controlled using a Feshbach
resonance. Building on previous theoretical work we identify quantitative
differences between the predictions of mean-field theory and the results of the
experiments. Besides the previously reported difference between the predicted
and observed critical atom number for collapse, we also find that the predicted
collapse times systematically exceed those observed experimentally. Quantum
field effects, such as fragmentation, that might account for these
discrepancies are discussed.Comment: 4 pages, 2 figure
A Connection between Twistors and Superstring Sigma Models on Coset Superspaces
We consider superstring sigma models that are based on coset superspaces G/H
in which H arises as the fixed point set of an order-4 automorphism of G. We
show by means of twistor theory that the corresponding first-order system,
consisting of the Maurer-Cartan equations and the equations of motion, arises
from a dimensional reduction of some generalised self-dual Yang-Mills equations
in eight dimensions. Such a relationship might help shed light on the explicit
construction of solutions to the superstring equations including their hidden
symmetry structures and thus on the properties of their gauge theory duals.Comment: v3: 16 pages, typos fixed and minor clarifications adde
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A randomised controlled trial of treatments of childhood anxiety disorder in the context of maternal anxiety disorder: clinical and cost-effectiveness outcomes
Background: This study evaluated whether clinical and economic outcomes from CBT for child anxiety disorders in the context of maternal anxiety disorders are improved by adding treatment focused on (i) maternal anxiety disorders, or (ii) mother-child interactions. Methods: 211 children (7 â 12 years, 85% White British, 52% female) with a primary anxiety disorder, whose mothers also had a current anxiety disorder, were randomised to receive (i) child-focused CBT with non-specific control interventions (CCBT+Con), (ii) CCBT with CBT for the maternal anxiety disorder (CCBT+MCBT), or (iii) CCBT with an intervention targeting the mother-child interaction (CCBT+MCI). A cost-utility analysis from a societal perspective was conducted using mother/child combined Quality Adjusted Life Years (QALYs). [Trial registration: https://doi.org/10.1186/ISRCTN19762288]. Results: MCBT was associated with immediate reductions in maternal anxiety compared to the non-specific control; however, after children had also received CCBT, maternal outcomes in the CCBT+MCI and CCBT+Con arms improved and CCBT+MCBT was no longer superior. Neither CCBT+MCBT nor CCBT+MCI conferred a benefit over CCBT+Con in terms of child anxiety disorder diagnoses post-treatment [primary outcome] (adj RR: 1.22 (95% CI 0.88, 1.67), p = .23; adj RR: 1.21 (95% CI 0.88, 1.65), p = .24 respectively) or global improvement ratings (adj RR 1.25 (95% CI 0.99, 1.57), p = .06; adj RR 1.18 (95% CI 0.93, 1.50), p = .17) or six and 12 months later. No significant differences between the groups were found on the main economic outcome measures (child/mother combined QALY mean difference: CCBT+MCBT vs CCBT+Con: -0.04 (95% CI -0.12, 0.04), p = 0.29; CCBT+MCI vs CCBT+Con: 0.02 (95% CI -0.05, -0.09), p = 0.54). CCBT+MCI was associated with non-significantly higher costs than CCBT (mean difference: ÂŁ154 (95% CI -ÂŁ1239, ÂŁ1547), p = 0.83) but, when taking into account sampling uncertainty, it may be cost-effective compared with CCBT alone. Conclusions: Good outcomes were achieved for children and their mothers across treatment arms. There was no evidence of significant clinical benefit from supplementing CCBT with either CBT for the maternal anxiety disorder or treatment focussed on mother-child interactions, but the addition of MCI (and not MCBT) may be cost-effective. Keywords: Child; anxiety; mother; parent-child interaction; CBT
Light propagation in non-trivial QED vacua
Within the framework of effective action QED, we derive the light cone
condition for homogeneous non-trivial QED vacua in the geometric optics
approximation. Our result generalizes the ``unified formula'' suggested by
Latorre, Pascual and Tarrach and allows for the calculation of velocity shifts
and refractive indices for soft photons travelling through these vacua.
Furthermore, we clarify the connection between the light velocity shift and the
scale anomaly. This study motivates the introduction of a so-called effective
action charge that characterizes the velocity modifying properties of the
vacuum. Several applications are given concerning vacuum modifications caused
by, e.g., strong fields, Casimir systems and high temperature.Comment: 13 pages, REVTeX, 3 figures, to appear in Phys. Rev.
Quantum Corrections to Dilute Bose Liquids
It was recently shown (A. Bulgac. Phys. Rev. Lett. {\bf 89}, 050402 (2002))
that an entirely new class of quantum liquids with widely tunable properties
could be manufactured from bosons (boselets), fermions (fermilets) and their
mixtures (ferbolets) by controlling their interaction properties by the means
of a Feshbach resonance. We extend the previous mean--field analysis of these
quantum liquids by computing the lowest order quantum corrections to the ground
state energy and the depletion of the Bose--Einstein condensate and by
estimating higher order corrections as well. We show that the quantum
corrections are relatively small and controlled by the diluteness parameter
, even though strictly speaking in this case there is no
low density expansion.Comment: final published version, typos corrected, updated references and
added one referenc
Statistical Survey of Type III Radio Bursts at Long Wavelengths Observed by the Solar TErrestrial RElations Observatory (STEREO)/Waves Instruments: Radio Flux Density Variations with Frequency
We have performed a statistical study of Type III radio bursts observed
by Solar TErrestrial RElations Observatory (STEREO)/Waves between May 2007 and
February 2013. We have investigated the flux density between kHz and
MHz. Both high- and low-frequency cutoffs have been observed in of
events suggesting an important role of propagation. As already reported by
previous authors, we observed that the maximum flux density occurs at MHz on
both spacecraft. We have developed a simplified analytical model of the flux
density as a function of radial distance and compared it to the STEREO/Waves
data.Comment: published in Solar Physic
Model study on the photoassociation of a pair of trapped atoms into an ultralong-range molecule
Using the method of quantum-defect theory, we calculate the ultralong-range
molecular vibrational states near the dissociation threshold of a diatomic
molecular potential which asymptotically varies as . The properties of
these states are of considerable interest as they can be formed by
photoassociation (PA) of two ground state atoms. The Franck-Condon overlap
integrals between the harmonically trapped atom-pair states and the
ultralong-range molecular vibrational states are estimated and compared with
their values for a pair of untrapped free atoms in the low-energy scattering
state. We find that the binding between a pair of ground-state atoms by a
harmonic trap has significant effect on the Franck-Condon integrals and thus
can be used to influence PA. Trap-induced binding between two ground-state
atoms may facilitate coherent PA dynamics between the two atoms and the
photoassociated diatomic molecule.Comment: 11 pages, 4 figures, to appear in Phys. Rev. A (September, 2003
Spectral method for the time-dependent Gross-Pitaevskii equation with a harmonic trap
We study the numerical resolution of the time-dependent Gross-Pitaevskii
equation, a non-linear Schroedinger equation used to simulate the dynamics of
Bose-Einstein condensates. Considering condensates trapped in harmonic
potentials, we present an efficient algorithm by making use of a spectral
Galerkin method, using a basis set of harmonic oscillator functions, and the
Gauss-Hermite quadrature. We apply this algorithm to the simulation of
condensate breathing and scissors modes.Comment: 23 pages, 5 figure
A systematic review of whether COVID-19 randomized controlled trials reported on demographic and clinical characteristics
Purpose: We aim to assess the reporting of key patient-level demographic and clinical characteristics among COVID-19 related randomized controlled trials (RCTs). Methods: We queried English-language articles from PubMed, Web of Science, clinicaltrials.gov, and the CDC library of gray literature databases using keywords of âcoronavirus,â âcovid,â âclinical trialâ and ârandomized controlled trialâ from January 2020 to June 2021. From the search, we conducted an initial review to rule-out duplicate entries, identify those that met inclusion criteria (i.e., had results), and exclude those that did not meet the definition of an RCT. Lastly, we abstracted the demographic and clinical characteristics reported on within each RCT. Results: From the initial 43 627 manuscripts, our final eligible manuscripts consisted of 149 RCTs described in 137 articles. Most of the RCTs (113/149) studied potential treatments, while fewer studied vaccines (29), prophylaxis strategies (5), and interventions to prevent transmission among those infected (2). Study populations ranged from 10 to 38 206 participants (median = 100, IQR: 60â300). All 149 RCTs reported on age, 147 on sex, 50 on race, and 110 on the prevalence of at least one comorbidity. No RCTs reported on income, urban versus rural residence, or other indicators of socioeconomic status (SES). Conclusions: Limited reporting on race and other markers of SES make it difficult to draw conclusions about specific external target populations without making strong assumptions that treatment effects are homogenous. These findings highlight the need for more robust reporting on the clinical and demographic profiles of patients enrolled in COVID-19 related RCTs
Development and external validation study of a melanoma risk prediction model incorporating clinically assessed naevi and solar lentigines
Background:
Melanoma risk prediction models could be useful for matching preventive interventions to patientsâ risk.
Objectives:
To develop and validate a model for incident firstâprimary cutaneous melanoma using clinically assessed risk factors.
Methods:
We used unconditional logistic regression with backward selection from the Australian Melanoma Family Study (461 cases and 329 controls) in which age, sex and city of recruitment were kept in each step, and we externally validated it using the Leeds Melanoma CaseâControl Study (960 cases and 513 controls). Candidate predictors included clinically assessed wholeâbody naevi and solar lentigines, and selfâassessed pigmentation phenotype, sun exposure, family history and history of keratinocyte cancer. We evaluated the predictive strength and discrimination of the model risk factors using odds per ageâ and sexâadjusted SD (OPERA) and the area under curve (AUC), and calibration using the HosmerâLemeshow test.
Results:
The final model included the number of naevi â„ 2 mm in diameter on the whole body, solar lentigines on the upper back (a sixâlevel scale), hair colour at age 18 years and personal history of keratinocyte cancer. Naevi was the strongest risk factor; the OPERA was 3·51 [95% confidence interval (CI) 2·71â4·54] in the Australian study and 2·56 (95% CI 2·23â2·95) in the Leeds study. The AUC was 0·79 (95% CI 0·76â0·83) in the Australian study and 0·73 (95% CI 0·70â0·75) in the Leeds study. The HosmerâLemeshow test Pâvalue was 0·30 in the Australian study and < 0·001 in the Leeds study.
Conclusions:
This model had good discrimination and could be used by clinicians to stratify patients by melanoma risk for the targeting of preventive interventions.
What's already known about this topic?
Melanoma risk prediction models may be useful in prevention by tailoring interventions to personalized risk levels.
For reasons of feasibility, time and cost many melanoma prediction models use selfâassessed risk factors. However, individuals tend to underestimate their naevus numbers.
What does this study add?
We present a melanoma risk prediction model, which includes clinicallyâassessed wholeâbody naevi and solar lentigines, and selfâassessed risk factors including pigmentation phenotype and history of keratinocyte cancer.
This model performs well on discrimination, the model's ability to distinguish between individuals with and without melanoma, and may assist clinicians to stratify patients by melanoma risk for targeted preventive interventions
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