Implementing Advanced RBAC Administration Functionality with USE

Role-based access control (RBAC) is a powerful means for laying out and developing higher-level organizational policies such as separation of duty, and for simplifying the security management process. One of the important aspects of RBAC is authorization constraints that express such organizational policies. While RBAC has generated a great interest in the security community, organizations still seek a flexible and effective approach to impose role-based authorization constraints in their security-critical applications. In particular, today often only basic RBAC concepts have found their way into commercial RBAC products; specifically, authorization constraints are not widely supported. In this paper, we present an RBAC administration tool that can enforce certain kinds of role-based authorization constraints such as separation of duty constraints. The authorization constraint functionality is based upon the OCL validation tool USE. We also describe our practical experience that we gained on integrating OCL functionality into a prototype of an RBAC administration tool that shall be extended to a product in the future

Apolipoprotein B is regulated by gonadotropins and constitutes a predictive biomarker of IVF outcomes

International audienceAbstractBackgroundFollicular fluid (FF) is an important micro-environment influencing oocyte growth, its development competence, and embryo viability. The FF content analysis allows to identify new relevant biomarkers, which could be predictive of in vitro fertilization (IVF) outcomes. Inside ovarian follicle, the amount of FF components from granulosa cells (GC) secretion, could be regulated by gonadotropins, which play a major role in follicle development.MethodsThis prospective study included 61 female undergoing IVF or Intra-cytoplasmic sperm injection (ICSI) procedure. Apolipoprotein B (APOB) concentrations in follicular fluid and APOB gene and protein expression in granulosa cells from reproductively aged women undergoing an in vitro fertilization program were measured. The statistical analyses were performed according to a quartile model based on the amount of APOB level found in FF.ResultsAmounts of APOB were detected in human FF samples (mean ± SD: 244.6 ± 185.9 ng/ml). The odds of obtaining an oocyte in the follicle and a fertilized oocyte increased significantly when APOB level in FF was higher than 112 ng/ml [i.e., including in Quartile Q 2, Q3 and Q4] (p = 0.001; p < 0.001, respectively). The probabilities of obtaining an embryo and a top quality embryo on day 2, were significantly higher if APOB levels were within the ranges of 112 and 330 ng/ml (i.e. in Q2 and Q3) or 112 and 230 ng/ml (i.e. in Q2), respectively (p < 0.001; p = 0.047, respectively). In addition, our experiments in vitro indicated that APOB gene and protein expression, along with APOB content into culture were significantly under-expressed in GC upon stimulation with gonadotropins (follicular stimulating hormone: FSH and/or human chorionic gonadotropin: hCG).ConclusionWe are reporting a positive and statistically significant associations between APOB and oocyte retrieval, oocyte fertilization, and embryo quality. Using an experimental study component, the authors report significant reduced APOB expression and content for luteinized granulosa cells cultured in the presence of gonadotropins

Rôle de la protéine de transfert des phospholipides (PLTP) dans le système reproductif mâle

DIJON-BU Médecine Pharmacie (212312103) / SudocSudocFranceF