Calculation of Geometrical Parameters of Geokhod Transmission With Hydraulic Cylinders

Developed analytical expressions for determining parameters of transmission hydraulic cylinders' arrangement are considered, as well as the conditions for internal arrangement of a required number of hydraulic cylinders

Calculation of Geometrical Parameters of Geokhod Transmission With Hydraulic Cylinders

Developed analytical expressions for determining parameters of transmission hydraulic cylinders' arrangement are considered, as well as the conditions for internal arrangement of a required number of hydraulic cylinders

Calculation of Free Interior Dimensions in Geokhod Transmission With Hydraulic Cylinders

Analytical expressions to specify overall dimensions of free interior in the geokhod, as well as its relation to design factors of a transmission and geokhod geometry are considered in the paper

DO POTOLKA PRYGAT’: Lexical and Grammar Changes of Idioms of Semantic Field of “Joy / Pleasure”

The features of the use of Russian idioms related to the semantic field of “Joy / Pleasure” are considered. Based on the analysis of idiomatic expressions (including speech formulas, the meaning of which contains a reference to the situation of communication), selected from lexicographic sources (ideographic dictionaries), the author identifies the main nominal components (somatisms, nouns “joy” and “pleasure” in their direct meanings, etc.), the elements of the figurative component (surface, container, physiological reactions, etc.) of the field of “Joy / Pleasure.” By analyzing examples of the use of phraseological units in the texts extracted from National Corpus of the Russian Language, the most typical lexical and grammatical changes in idioms are revealed, namely: syntactic transformations (inversion and topicalization), lexical modifications (component replacement), lexical and syntactic modifications (definition input). The author comes to the following conclusions: on the one hand, lexical and grammatical changes of idioms are directly caused by the semantics of idioms (for example, with such morphological modification as the change of verbal form); on the other hand, these changes themselves may cause the transformation of the meaning of the idiom for its actualization in the context. In addition, there is a tendency to generalization: on the basis of idioms of this semantic field there are phraseoschemes-intensifiers, which can also apply to other fields (in particular, to the field “Fear”)

Patterns of Pathomorphological Changes in Acute Necrotizing Pancreatitis

Acinar necrosis is the basic microscopic sign of acute necrotizing pancreatitis (ANP). Microcirculation disorder is one of the major factors in the pathogenesis and morphogenesis of ANP besides free radicals and damage of enzymatic origin. This study is dedicated to the description of microscopic changes in the pancreatic stroma in ANP, which leads to destruction of the exocrine pancreas with a putative mechanism of endocrine function preservation. This study has been carried out on histological samples of pancreas from 224 patients with ANP. Histological staining was performed with hematoxylin-eosin (H&E), Masson, Gomori methods, and PAS. Microscopy was performed with magnifications of 40×, 100×, and 400×. Vascular endothelial desquamation, stasis, and sludge are typical changes in microcirculation observed in early stages of ANP. Initially, parietal circular intravascular microthrombosis accompanied by endothelial desquamation as early as stromal swelling occurs with no detectable necrosis. Residual stroma appears between areas of necrosis and intact pancreatic tissue. Mucoid swelling is first seen in the perivascular spaces extending to the parenchyma and changing into fibrinoid imbibition causing further necrosis. Reticulin argyrophilic backbone surrounding the pancreatic acini and small ducts decompose. Pancreatic structures, which may be preserved in necrotic tissue, include nerves, major ducts, and Langerhans islets

Basin structure in the two-dimensional dissipative circle map

Fractal basin structure in the two-dimensional dissipative circle map is examined in detail. Numerically obtained basin appears to be riddling in the parameter region where two periodic orbits co-exist near a boundary crisis, but it is shown to consist of layers of thin bands.Comment: published in J. Phys. Soc. Jpn., 72, 1943-1947 (2003

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical manifestations of specific forms of pathology. Combined drugs that help normalize the central regulatory mechanisms of the development of somatic pathology, improve brain metabolism and hemodynamics, stabilize the cortical-subcortical relationships, the disorders of which lie at the base of many forms of neurological and psychosomatic pathology have been particularly popular in recent years. In this article we propose options for opti­mizing nootropic therapy with olatropyl, which is a combination of two "true" nootropics - gamma-aminobutyric acid (aminalone) and piracetam in one drug form. Such a combination allows one-stage implementation of a complex of multifaceted and diverse effects on the central nervous system characteristic of both piracetam and aminalone, but achieved through fundamentally different mechanisms of action of these agents. The mechanism of action of olatropil demonstrates the pronounced synergism of the monocomponents of the preparation. This combination allows to reduce the therapeutic dosages of each of the active substances by 2 times, which, in turn, leads to a decrease in the incidence and severity of possible side effects; leveling the exciting effect of piracetam and providing higher safety and efficacy. The drug is an effective tool for the therapy of various forms of cerebrovascular pathology, improving cognitive functions, mental activity, psychoemotional status, autonomic functions, favorably affecting the quality of life of patients. The uniqueness of the mechanism of action of olatropil, consisting in the occurrence of the fact of pharmacodynamic synergy in the combined use of piracetam and aminalone in a single dosage form, contributes to the enhancement of positive pharmacological effects and the leveling of a number of negative elements of pharmacodynamics of preparation constituents

Synergy of piracetam and aminalon in the cerebroprotective effect of olatropyl.

Optimization of pharmacotherapy of neurological and psychosomatic diseases led to the creation of com­bined medicines containing two or more components with different mechanisms of action, differently affecting the pathogenesis and clinical manifestations of specific forms of pathology. Combined drugs that help normalize the central regulatory mechanisms of the development of somatic pathology, improve brain metabolism and hemodynamics, stabilize the cortical-subcortical relationships, the disorders of which lie at the base of many forms of neurological and psychosomatic pathology have been particularly popular in recent years. In this article we propose options for opti­mizing nootropic therapy with olatropyl, which is a combination of two "true" nootropics - gamma-aminobutyric acid (aminalone) and piracetam in one drug form. Such a combination allows one-stage implementation of a complex of multifaceted and diverse effects on the central nervous system characteristic of both piracetam and aminalone, but achieved through fundamentally different mechanisms of action of these agents. The mechanism of action of olatropil demonstrates the pronounced synergism of the monocomponents of the preparation. This combination allows to reduce the therapeutic dosages of each of the active substances by 2 times, which, in turn, leads to a decrease in the incidence and severity of possible side effects; leveling the exciting effect of piracetam and providing higher safety and efficacy. The drug is an effective tool for the therapy of various forms of cerebrovascular pathology, improving cognitive functions, mental activity, psychoemotional status, autonomic functions, favorably affecting the quality of life of patients. The uniqueness of the mechanism of action of olatropil, consisting in the occurrence of the fact of pharmacodynamic synergy in the combined use of piracetam and aminalone in a single dosage form, contributes to the enhancement of positive pharmacological effects and the leveling of a number of negative elements of pharmacodynamics of preparation constituents