Protons at the Gate DEG/ENaC Ion Channels Help Us Feel and Remember

AbstractThe DEG/ENaC ion channel family contributes to channels of striking functional diversity. Neuronally expressed family members include the C. elegans degenerins that mediate touch and are thought to be mechanically gated, and the mammalian ASICs, which are gated by protons. ASICs affect a range of sensory functions that includes perception of gentle touch, harsh touch, heat, sour taste, and pain. Family member ASIC1 is now implicated in long-term potentiation, suggesting that minute fluxes in synaptic pH may activate ASICs to enhance learning

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

In many organisms, dietary restriction appears to extend lifespan, at least in part, by down-regulating the nutrient-sensor TOR (Target Of Rapamycin). TOR inhibition elicits autophagy, the large-scale recycling of cytoplasmic macromolecules and organelles. In this study, we asked whether autophagy might contribute to the lifespan extension induced by dietary restriction in C. elegans. We find that dietary restriction and TOR inhibition produce an autophagic phenotype and that inhibiting genes required for autophagy prevents dietary restriction and TOR inhibition from extending lifespan. The longevity response to dietary restriction in C. elegans requires the PHA-4 transcription factor. We find that the autophagic response to dietary restriction also requires PHA-4 activity, indicating that autophagy is a transcriptionally regulated response to food limitation. In spite of the rejuvenating effect that autophagy is predicted to have on cells, our findings suggest that autophagy is not sufficient to extend lifespan. Long-lived daf-2 insulin/IGF-1 receptor mutants require both autophagy and the transcription factor DAF-16/FOXO for their longevity, but we find that autophagy takes place in the absence of DAF-16. Perhaps autophagy is not sufficient for lifespan extension because although it provides raw material for new macromolecular synthesis, DAF-16/FOXO must program the cells to recycle this raw material into cell-protective longevity proteins

Upcycling of low value end-of-life cathode material into next generation cathode materials

The increase in the use of electric vehicles (EVs) will ultimately lead to an increase in the number of end-of-life lithium-ion batteries (LIBs) that need to be recycled. A particular challenge concerns how to deal with low value cathodes, such as LiMn2O4 (LMO). To this end, this paper investigates recycling cathode material from an end-of-life Gen 1 Nissan Leaf (2011 model, 40 000 miles) which contains a mixture of spinel (LMO) and a Ni-rich layered oxide (LO). Citric acid was employed to selectively leach LMO into solution while leaving the remaining LO as a solid. The citric acid also acts as a delamination agent to remove the remaining LO from the Al current collector. The LMO was then recovered from solution and upcycled to form new cathode materials. Ni-doping of the solution allowed the synthesis of the high voltage cathode LiMn1.5Ni0.5O4 (LMNO) which is attracting commercial interest. Disordered rocksalt compounds Li4Mn2O5 and Li2MnO2.25F were also synthesised and gave high specific discharge capacities of 293 and 279 mA h g−1 respectively. This proof of concept work demonstrates a method to upcycle end-of-life cathode material into next generation cathode materials

The phylogeny of Heliconia (Heliconiaceae) and the evolution of floral presentation

© 2016 Elsevier Inc. Heliconia (Heliconiaceae, order Zingiberales) is among the showiest plants of the Neotropical rainforest and represent a spectacular co-evolutionary radiation with hummingbirds. Despite the attractiveness and ecological importance of many Heliconia, the genus has been the subject of limited molecular phylogenetic studies. We sample seven markers from the plastid and nuclear genomes for 202 samples of Heliconia. This represents ca. 75% of accepted species and includes coverage of all taxonomic subgenera and sections. We date this phylogeny using fossils associated with other families in the Zingiberales; in particular we review and evaluate the Eocene fossil Ensete oregonense. We use this dated phylogenetic framework to evaluate the evolution of two components of flower orientation that are hypothesized to be important for modulating pollinator discrimination and pollen placement: resupination and erect versus pendant inflorescence habit. Our phylogenetic results suggest that the monophyletic Melanesian subgenus Heliconiopsis and a small clade of Ecuadorian species are together the sister group to the rest of Heliconia. Extant diversity of Heliconia originated in the Late Eocene (39 Ma) with rapid diversification through the Early Miocene, making it the oldest known clade of hummingbird-pollinated plants. Most described subgenera and sections are not monophyletic, though closely related groups of species, often defined by shared geography, mirror earlier morphological cladistic analyses. Evaluation of changes in resupination and inflorescence habit suggests that these characters are more homoplasious than expected, and this largely explains the non-monophyly of previously circumscribed subgenera, which were based on these characters. We also find strong evidence for the correlated evolution of resupination and inflorescence habit. The correlated model suggests that the most recent common ancestor of all extant Heliconia had resupinate flowers and erect inflorescences. Finally, we note our nearly complete species sampling and dated phylogeny allow for an assessment of taxonomic history in terms of phylogenetic diversity. We find approximately half of the currently recognized species, corresponding to half of the phylogenetic diversity, have been described since 1975, highlighting the continued importance of basic taxonomic research and conservation initiatives to preserve both described and undiscovered species of Heliconia

Childhood Obesity in Florida: A Narrative Review on Current Trends and Interventions

We examine current research on childhood obesity (CO) trends and intervention strategies in Florida. The fiscal, emotional, and health-related costs related to general obesity are staggering. Unfortunately, CO-related publicity, research, policy, and interventions have not been entirely successful in addressing the problem. Florida ranks 35thnationally in prevalence of CO. Data from the Centers for Disease Control and Prevention (CDC) 2013 report a statistically significant decrease in Florida\u27s rate of CO among 2-4 year-olds participating in Florida’s Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) from 2008-2011. Whereas Florida still has significant room for improvement on the issue of CO, its relatively low CO prevalence indicates a step in the right direction. Information provided herein provides valuable insight, resource information, and motivation to healthcare providers, particularly registered dietitian nutritionists (RDNs). As nutrition experts employed in various areas of society, RDNs are advantageously situated to contribute significantly to the CO solution. Florida appears to benefit from interdisciplinary collaborations among healthcare facilities, schools, faith-based organizations, governmental agencies, and grassroots programs that may play a major role in the current fight against CO