Low-dimensional space- and time-coupled power system control policies driven by high-dimensional ensemble weather forecasts

Many predictive control problems can be solved at lower cost if the practitioner is able to make use of a high-dimensional forecast of exogenous uncertain quantities. For example, power system operators must accommodate significant short-term uncertainty in renewable energy infeeds. These are predicted using sophisticated numerical weather models, which produce an ensemble of scenarios for the evolution of atmospheric conditions. We describe a means of incorporating such forecasts into a multistage optimization framework able to make use of spatial and temporal correlation information. We derive an optimal procedure for reducing the size of the look-ahead problem by generating a low-dimensional representation of the uncertainty, while still retaining as much information as possible from the raw forecast data. We then demonstrate application of this technique to a model of the Great Britain grid in 2030, driven by the raw output of a real-world high-dimensional weather forecast from the U.K. Met Office. We also discuss applications of the approach beyond power systems

\u3cem\u3eIn vivo\u3c/em\u3e Imaging of Human Retinal Microvasculature Using Adaptive Optics Scanning Light Ophthalmoscope Fluorescein Angiography

The adaptive optics scanning light ophthalmoscope (AOSLO) allows visualization of microscopic structures of the human retina in vivo. In this work, we demonstrate its application in combination with oral and intravenous (IV) fluorescein angiography (FA) to the in vivo visualization of the human retinal microvasculature. Ten healthy subjects ages 20 to 38 years were imaged using oral (7 and/or 20 mg/kg) and/or IV (500 mg) fluorescein. In agreement with current literature, there were no adverse effects among the patients receiving oral fluorescein while one patient receiving IV fluorescein experienced some nausea and heaving. We determined that all retinal capillary beds can be imaged using clinically accepted fluorescein dosages and safe light levels according to the ANSI Z136.1-2000 maximum permissible exposure. As expected, the 20 mg/kg oral dose showed higher image intensity for a longer period of time than did the 7 mg/kg oral and the 500 mg IV doses. The increased resolution of AOSLO FA, compared to conventional FA, offers great opportunity for studying physiological and pathological vascular processes

Student Wellness Center & SMART Lab: A Student Life & Educational Studies Partnership

The Office of Student Life Student Wellness Center at The Ohio State University defines wellness as an active, ongoing process which involves becoming aware of and taking steps toward a healthier, happier, successful life. To that end, we have partnered with the Department of Educational Studies in the College of Education and Human Ecology to implement wellness programs and engage in wellness-related research for the benefit of Ohio State students. The Wellness Coaching program proposes a new approach to health promotion by orienting programs and services toward a holistic model of wellness that aspires to help students maximize their potential across nine dimensions (career, creative, emotional, environmental, financial, intellectual, physical, social, and spiritual). The mission of the Stress Management and Resiliency Training lab is to teach and research the efficacy of stress management and resiliency skills to our clients. We provide a number of coaching, computer mediated learning, and group activity services for this purpose. These two services share a space on the fourth floor of the Physical Activities and Educational Services building, located at 305 Annie and John Glenn Ave., providing opportunities for collaboration and partnership. In the spirit of community engagement, we plan to present a poster to show the variety of ways the rare partnership between an academic department and student life office can benefit students through increased services and engaged research. Our staff is comprised of graduate students from different disciplines bringing unique skills and expertise to accomplish our goals: Mackenzie Hogan serves as the graduate administrative associate for the wellness coaching program at Ohio State. She earned her B.A. in community leadership with a minor in education from Ohio State and is currently working on completing her master's in higher education and student affairs. Mackenzie previously worked full-time for the university in the Office of the President. Damon Drew serves as the graduate teaching associate for the Stress Management and Resiliency Training laboratory. He earned his master's of education in clinical mental health counseling from the University of Louisville. He has worked as a clinical counselor in community, school, university, and hospital settings. Blake Marble serves as the associate director of the Student Life Student Wellness Center. In this role, he provides leadership by working with staff and students to create a campus environment that promotes and supports student success and well-being. Blake has served in a variety of roles since joining the Student Life Student Wellness Center team in July 2013, most recently in a leadership capacity addressing high-risk behaviors and enhancing peer education efforts at Ohio State. Blake received his B.S. in exercise science and M.Ed. in administration of higher education from Auburn University.AUTHOR AFFILIATION: Damon Drew, Graduate Teaching Associate, Department of Educational Studies, [email protected] (Corresponding Author); Blake Marble, Associate Director, Student Life Wellness Center; Mackenzie Hogan, Graduate Administrative Associate, Student Life Student Wellness Center.The Office of Student Life Student Wellness Center and Department of Educational Studies have partnered to provide wellness services to Ohio State students. The Wellness Coaching program at Ohio State proposes a new approach to health promotion by orienting programs and services toward a holistic model of wellness that aspires to help students maximize their potential across nine dimensions (career, creative, emotional, environmental, financial, intellectual, physical, social, and spiritual). The Stress Management and Resiliency Training Lab provides a number of coaching, computer-mediated learning and group-activity services for this purpose. These two services share a space on the fourth floor of the Physical Activities and Educational Services building, which provides opportunities for collaboration and partnership. It is our hope that academic departments and student life offices can use this information to partner and provide more services to students

\u3cem\u3eIn vivo\u3c/em\u3e Imaging of Human Cone Photoreceptor Inner Segments

Purpose. An often overlooked prerequisite to cone photoreceptor gene therapy development is residual photoreceptor structure that can be rescued. While advances in adaptive optics (AO) retinal imaging have recently enabled direct visualization of individual cone and rod photoreceptors in the living human retina, these techniques largely detect strongly directionally-backscattered (waveguided) light from normal intact photoreceptors. This represents a major limitation in using existing AO imaging to quantify structure of remnant cones in degenerating retina. Methods. Photoreceptor inner segment structure was assessed with a novel AO scanning light ophthalmoscopy (AOSLO) differential phase technique, that we termed nonconfocal split-detector, in two healthy subjects and four subjects with achromatopsia. Ex vivo preparations of five healthy donor eyes were analyzed for comparison of inner segment diameter to that measured in vivo with split-detector AOSLO. Results. Nonconfocal split-detector AOSLO reveals the photoreceptor inner segment with or without the presence of a waveguiding outer segment. The diameter of inner segments measured in vivo is in good agreement with histology. A substantial number of foveal and parafoveal cone photoreceptors with apparently intact inner segments were identified in patients with the inherited disease achromatopsia. Conclusions. The application of nonconfocal split-detector to emerging human gene therapy trials will improve the potential of therapeutic success, by identifying patients with sufficient retained photoreceptor structure to benefit the most from intervention. Additionally, split-detector imaging may be useful for studies of other retinal degenerations such as AMD, retinitis pigmentosa, and choroideremia where the outer segment is lost before the remainder of the photoreceptor cell

Tangled up in Tanglegrams

Tanglegrams are graphs consisting of two rooted binary plane trees with the same number of leaves and a perfect matching between the two leaf sets. A Tanglegram drawing is a special way of drawing a Tanglegram; and a Tanglegram is called planar if it has a drawing such that the matching edges do not cross. In this thesis, we will discuss various results related to the construction and planarity of Tanglegrams, as well as demonstrate how to construct all the Tanglegrams of size 4 by looking at two types of rooted binary trees - Caterpillar and Complete Binary Trees. After augmenting a Tanglegram with an edge between its roots, we will prove that the Tanglegram crossing number of the original Tanglegram is greater than or equal to the crossing number of the augmented Tanglegram taken as a graph. We will show that the removal of a matching edge from a Tanglegram of size n ≥3 decreases the Tanglegram crossing number by at most n − 3, and give a family of 1-edge panar Tanglegrams (one for every n ≥3) of size n with Tangle crossing number n − 3, showing that the previous statement is sharp. We will also discuss various conditions on the nonplanarity of Tanglegrams

Photoreceptor Inner Segment Morphology in Best Vitelliform Macular Dystrophy

PURPOSE To characterize outer retina structure in best vitelliform macular dystrophy (BVMD) and to determine the effect of macular lesions on overlying and adjacent photoreceptors. METHODS Five individuals with BVMD were followed prospectively with spectral domain optical coherence tomography and confocal and nonconfocal split-detector adaptive optics scanning light ophthalmoscopy (AOSLO). The AOSLO cone photoreceptor mosaic images were obtained within and around retinal lesions. Cone density was measured inside and outside lesions. In 2 subjects, densities were compared with published measurements acquired ∼2.5 years before. One subject was imaged 3 times over a 5-month period. RESULTS The AOSLO imaging demonstrated that photoreceptor morphology within BVMD retinal lesions was highly variable depending on the disease stage, with photoreceptor structure present even in advanced disease. The AOSLO imaging was repeatable even in severe disease over short-time and long-time intervals. Photoreceptor density was normal in retinal areas immediately adjacent to lesions and stable over ∼2.5 years. Mobile disk-like structures possibly representing subretinal macrophages were also observed. CONCLUSION Combined confocal and nonconfocal split-detector AOSLO imaging reveals substantial variability within clinical lesions in all stages of BVMD. Longitudinal cellular photoreceptor imaging could prove a powerful tool for understanding disease progression and monitoring emerging therapeutic treatment response in inherited degenerations such as BVMD