Resistant starch as a dietary intervention to limit the progression of diabetic kidney disease

Diabetes is the leading cause of kidney disease, and as the number of individuals with diabetes increases there is a concomitant increase in the prevalence of diabetic kidney disease (DKD). Diabetes contributes to the development of DKD through a number of pathways, including inflammation, oxidative stress, and the gut-kidney axis, which may be amenable to dietary therapy. Resistant starch (RS) is a dietary fibre that alters the gut microbial consortium, leading to an increase in the microbial production of short chain fatty acids. Evidence from animal and human studies indicate that short chain fatty acids are able to attenuate inflammatory and oxidative stress pathways, which may mitigate the progression of DKD. In this review, we evaluate and summarise the evidence from both preclinical models of DKD and clinical trials that have utilised RS as a dietary therapy to limit the progression of DKD

The Spectra of Red Quasars

We measure the spectral properties of a representative sub-sample of 187 quasars, drawn from the Parkes Half-Jansky, Flat-radio-spectrum Sample (PHFS). Quasars with a wide range of rest-frame optical/UV continuum slopes are included in the analysis: their colours range from 2 < B-K < 7. The median H-beta and [O III] emission-line equivalent widths of the red quasar sub-sample are a factor of ten weaker than those of the blue quasar sub-sample. Both the colours and the emission-line equivalent widths of the red quasars can be explained by the addition of a featureless red synchrotron continuum component to an otherwise normal blue quasar spectrum. The relative strengths of the blue and red components span two orders of magnitude at rest-frame 500nm. The blue component is weaker relative to the red component in low optical luminosity sources. This suggests that the fraction of accretion energy going into optical emission from the jet is greater in low luminosity quasars. This synchrotron model does not, however, fit around 10% of the quasars, which have both red colours and high equivalent width emission-lines. We hypothesise that these red, strong-lined quasars have intrinsically weak Big Blue Bumps. There is no discontinuity in spectral properties between the BL Lac objects in our sample and the other quasars. The synchrotron emission component only dominates the spectrum at longer wavelengths, so existing BL Lac surveys will be biassed against high redshift objects.Comment: 22 pages, 12 figures, accepted for publication in PASA. Data tables and composite spectra from the paper can be found at http://msowww.anu.edu.au/~pfrancis

Laser induced fluorescence characterization of ions emitted from hollow cathodes

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76900/1/AIAA-1999-2862-539.pd

Supplementary data and analysis for estimating walleye selectivity

This document has been issued as VIMS Data Report 61 and provides data tables and results of exploratory analyses conducted as part of the complete data analysis for Myers et al. 2014 published in the Transactions of the American Fisheries Society. Estimates of size- and sex-specific selectivity of fishing gear are important for making informed management decisions. We distinguish between capture selectivity – the relative catchability of the components of the population – and harvest selectivity, which is the combined effects of capture selectivity and the decision to retain or release a fish of a given population component. We used short-term recaptures from three extensive tagging programs in Minnesota and Wisconsin to estimate directly the size- and sex- specific selectivity of angling for captured and for harvested walleye Sander vitreus, and of spear fishing for harvested walleye. Estimates were obtained using generalized linear models with an information-theoretic approach to determining the significance of individual and interactive effects of length and sex on selectivity. The primary conclusions of this research are presented in Myers et al. 2014. Residual analyses for the models presented in the manuscript, results of unpublished exploratory analyses, and the complete data set used to conduct the analyses are presented in this supplementary document. Through this data report, interested readers can repeat the analyses conducted in Myers et al. 2014, as well as see the results of additional analyses not presented in the primary publication

Search for Nanosecond Near-infrared Transients around 1280 Celestial Objects

Stars and planetary system

Myeloma cells down‐regulate adiponectin in bone marrow adipocytes via TNF‐alpha

Multiple myeloma is caused by abnormal plasma cells that accumulate in the bone marrow and interact with resident cells of the bone microenvironment to drive disease progression and development of an osteolytic bone disease. Bone marrow adipocytes (BMAds) are emerging as having important endocrine functions that can support myeloma cell growth and survival. However, how BMAds respond to infiltrating tumor cells remains poorly understood. Using the C57BL/KaLwRij murine model of myeloma, bone marrow adiposity was found to be increased in early stage myeloma with BMAds localizing along the tumor‐bone interface at later stages of disease. Myeloma cells were found to uptake BMAd‐derived lipids in vitro and in vivo, although lipid uptake was not associated with the ability of BMAds to promote myeloma cell growth and survival. However, BMAd‐derived factors were found to increase myeloma cell migration, viability, and the evasion of apoptosis. BMAds are a major source of adiponectin, which is known to be myeloma‐suppressive. Myeloma cells were found to downregulate adiponectin specifically in a model of BMAds but not in white adipocytes. The ability of myeloma cells to downregulate adiponectin was dependent at least in part on TNF‐α. Collectively our data support the link between increased bone marrow adiposity and myeloma progression. By demonstrating how TNF‐α downregulates BMAd‐derived adiponectin, we reveal a new mechanism by which myeloma cells alter the bone microenvironment to support disease progression. © 2019 The Authors. Journal of Bone and Mineral Research published by American Society for Bone and Mineral Research

Preliminary Results on HAT-P-4, TrES-3, XO-2, and GJ 436 from the NASA EPOXI Mission

EPOXI (EPOCh + DIXI) is a NASA Discovery Program Mission of Opportunity using the Deep Impact flyby spacecraft. The EPOCh (Extrasolar Planet Observation and Characterization) Science Investigation will gather photometric time series of known transiting exoplanet systems from January through August 2008. Here we describe the steps in the photometric extraction of the time series and present preliminary results of the first four EPOCh targets.Comment: 4 pages, 2 figures. To appear in the Proceedings of the 253rd IAU Symposium: "Transiting Planets", May 2008, Cambridge, M

Proceedings of the 2022 Santa Fe Bone Symposium : Current concepts in the care of patients with osteoporosis and metabolic bone diseases

The 22nd Annual Santa Fe Bone Symposium (SFBS) was a hybrid meeting held August 5-6, 2022, with in-person and virtual attendees. Altogether, over 400 individuals registered, a majority of whom attended in-person, representing many states in the USA plus 7 other countries. The SFBS included 10 plenary presentations, 2 faculty panel discussions, satellite symposia, Bone Health & Osteoporosis Foundation Fracture Liaison Service Boot Camp, and a Project ECHO workshop, with lively interactive discussions for all events. Topics of interest included fracture prevention at different stages of life; how to treat and when to change therapy; skeletal health in cancer patients; advanced imaging to assess bone strength; the state of healthcare in the USA; osteosarcopenia; vitamin D update; perioperative bone health care; new guidelines for managing primary hyperparathyroidism; new concepts on bone modeling and remodeling; and an overview on the care of rare bone diseases, including hypophosphatasia, X-linked hypophosphatemia, tumor induced osteomalacia, osteogenesis imperfecta, fibrodysplasia ossificans progressiva, and osteopetrosis. The SFBS was preceded by the Santa Fe Fellows Workshop on Osteoporosis and Metabolic Bone Diseases, a collaboration of the Endocrine Fellows Foundation and the Osteoporosis Foundation of New Mexico. From the Workshop, 4 participating fellows were selected to give oral presentations at the bone symposium. These proceedings represent the clinical highlights of 2022 SFBS presentations and the discussions that followed, all with the aim of optimizing skeletal health and minimizing the consequences of fragile bones