''Διερευνώντας το φαινόμενο της μετανάστευσης των νέων του νότου : οι επιλογές κατοίκησης"

Εθνικό Μετσόβιο Πολυτεχνείο. Μεταπτυχιακή εργασία. Διεπιστημονικό - Διατμηματικό Πρόγραμμα Μεταπτυχιακών Σπουδών (Δ.Π.Μ.Σ.) "Αρχιτεκτονική - Σχεδιασμός του Χώρου : Πολεοδομία - Χωροταξία (Κατ. Β')

Shelley and Berkeley: The Platonic Connection

[Δεν διατίθεται περίληψη / no abstract available

Long non‐coding RNAs in development and disease: Conservation to mechanisms

Our genomes contain the blueprint of what makes us human and many indications as to why we develop disease. Until the last 10 years, most studies had focussed on protein‐coding genes, more specifically DNA sequences coding for proteins. However, this represents less than 5% of our genomes. The other 95% is referred to as the ‘dark matter’ of our genomes, our understanding of which is extremely limited. Part of this ‘dark matter’ includes regions that give rise to RNAs that do not code for proteins. A subset of these non‐coding RNAs are long non‐coding RNAs (lncRNAs), which in particular are beginning to be dissected and their importance to human health revealed. To improve our understanding and treatment of disease it is vital that we understand the molecular and cellular function of lncRNAs, and how their misregulation can contribute to disease. It is not yet clear what proportion of lncRNAs is actually functional; conservation during evolution is being used to understand the biological importance of lncRNA. Here, we present key themes within the field of lncRNAs, emphasising the importance of their roles in both the nucleus and the cytoplasm of cells, as well as patterns in their modes of action. We discuss their potential functions in development and disease using examples where we have the greatest understanding. Finally, we emphasise why lncRNAs can serve as biomarkers and discuss their emerging potential for therapy

DATING THE BRONZE AGE OF SOUTHEAST ASIA. WHY DOES IT MATTER?

We have dated human bone, freshwater shell, charcoal and rice grains from key sites in mainland Southeast Asia in order to establish the chronological scaffolding for later prehistory (ca 2500 BC-AD 500). In a recent report on the metal remains from the site of Ban Chiang, however, this chronology has been challenged. Here, we respond to these claims and show that they are unfounded and misleading. We maintain the integrity of the Bayesian-modelled radiocarbon results that identify the arrival of the first rice and millet farmers in mainland Southeast Asia towards the end of the 3rd millennium BC, with the first evidence for the casting of bronze by about 1100 BC. Social change that followed the establishment of metallurgy was rapid and profound.