2,187 research outputs found
Signatures of Pseudoscalar Photon Mixing in CMB Radiation
We model the effect of photon and ultra-light pseudoscalar mixing on the
propagation of electromagnetic radiation through the extragalactic medium. The
medium is modelled as a large number of magnetic domains, uncorrelated with one
another. We obtain an analytic expression for the different Stokes parameters
in the limit of small mixing angle. The different Stokes parameters are found
to increase linearly with the number of domains. We also verify this result by
direct numerical simulations. We use this formalism to estimate the effect of
pseudoscalar-photon mixing on the Cosmic Microwave Background (CMB)
polarization. We impose limits on the model parameters by the CMB observations.
We find that the currently allowed parameter range admits a CMB circular
polarization up to order .Comment: 17 pages, 5 figure
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways.
Perlecan Domain V (DV) promotes brain angiogenesis by inducing VEGF release from brain endothelial cells (BECs) following stroke. In this study, we define the specific mechanism of DV interaction with the α(5)β(1) integrin, identify the downstream signal transduction pathway, and further investigate the functional significance of resultant VEGF release. Interestingly, we found that the LG3 portion of DV, which has been suggested to possess most of DV\u27s angio-modulatory activity outside of the brain, binds poorly to α(5)β(1) and induces less BEC proliferation compared to full length DV. Additionally, we implicate DV\u27s DGR sequence as an important element for the interaction of DV with α(5)β(1). Furthermore, we investigated the importance of AKT and ERK signaling in DV-induced VEGF expression and secretion. We show that DV increases the phosphorylation of ERK, which leads to subsequent activation and stabilization of eIF4E and HIF-1α. Inhibition of ERK activity by U0126 suppressed DV-induced expression and secretion of VEGR in BECs. While DV was capable of phosphorylating AKT we show that AKT phosphorylation does not play a role in DV\u27s induction of VEGF expression or secretion using two separate inhibitors, LY294002 and Akt IV. Lastly, we demonstrate that VEGF activity is critical for DV increases in BEC proliferation, as well as angiogenesis in a BEC-neuronal co-culture system. Collectively, our findings expand our understanding of DV\u27s mechanism of action on BECs, and further support its potential as a novel stroke therapy
Chlamydia trachomatis from Australian Aboriginal people with trachoma are polyphyletic composed of multiple distinctive lineages.
Chlamydia trachomatis causes sexually transmitted infections and the blinding disease trachoma. Current data on C. trachomatis phylogeny show that there is only a single trachoma-causing clade, which is distinct from the lineages causing urogenital tract (UGT) and lymphogranuloma venerum diseases. Here we report the whole-genome sequences of ocular C. trachomatis isolates obtained from young children with clinical signs of trachoma in a trachoma endemic region of northern Australia. The isolates form two lineages that fall outside the classical trachoma lineage, instead being placed within UGT clades of the C. trachomatis phylogenetic tree. The Australian trachoma isolates appear to be recombinants with UGT C. trachomatis genome backbones, in which loci that encode immunodominant surface proteins (ompA and pmpEFGH) have been replaced by those characteristic of classical ocular isolates. This suggests that ocular tropism and association with trachoma are functionally associated with some sequence variants of ompA and pmpEFGH
The effect of Ku on telomere replication time is mediated by telomere length but is independent of histone tail acetylation
Peer reviewedPublisher PD
Planetary Candidates Observed by Kepler IV: Planet Sample From Q1-Q8 (22 Months)
We provide updates to the Kepler planet candidate sample based upon nearly
two years of high-precision photometry (i.e., Q1-Q8). From an initial list of
nearly 13,400 Threshold Crossing Events (TCEs), 480 new host stars are
identified from their flux time series as consistent with hosting transiting
planets. Potential transit signals are subjected to further analysis using the
pixel-level data, which allows background eclipsing binaries to be identified
through small image position shifts during transit. We also re-evaluate Kepler
Objects of Interest (KOI) 1-1609, which were identified early in the mission,
using substantially more data to test for background false positives and to
find additional multiple systems. Combining the new and previous KOI samples,
we provide updated parameters for 2,738 Kepler planet candidates distributed
across 2,017 host stars. From the combined Kepler planet candidates, 472 are
new from the Q1-Q8 data examined in this study. The new Kepler planet
candidates represent ~40% of the sample with Rp~1 Rearth and represent ~40% of
the low equilibrium temperature (Teq<300 K) sample. We review the known biases
in the current sample of Kepler planet candidates relevant to evaluating planet
population statistics with the current Kepler planet candidate sample.Comment: 12 pages, 8 figures, Accepted ApJ Supplemen
Computer Simulations of Supercooled Liquids and Glasses
After a brief introduction to the dynamics of supercooled liquids, we discuss
some of the advantages and drawbacks of computer simulations of such systems.
Subsequently we present the results of computer simulations in which the
dynamics of a fragile glass former, a binary Lennard-Jones system, is compared
to the one of a strong glass former, SiO_2. This comparison gives evidence that
the reason for the different temperature dependence of these two types of glass
formers lies in the transport mechanism for the particles in the vicinity of
T_c, the critical temperature of mode-coupling theory. Whereas the one of the
fragile glass former is described very well by the ideal version of
mode-coupling theory, the one for the strong glass former is dominated by
activated processes. In the last part of the article we review some simulations
of glass formers in which the dynamics below the glass transition temperature
was investigated. We show that such simulations might help to establish a
connection between systems with self generated disorder (e.g. structural
glasses) and quenched disorder (e.g. spin glasses).Comment: 37 pages of Latex, 11 figures, to appear as a Topical Review article
in J. Phys.: Condens. Matte
Discovery and Rossiter-McLaughlin Effect of Exoplanet Kepler-8b
We report the discovery and the Rossiter-McLaughlin effect of Kepler-8b, a
transiting planet identified by the NASA Kepler Mission. Kepler photometry and
Keck-HIRES radial velocities yield the radius and mass of the planet around
this F8IV subgiant host star. The planet has a radius RP = 1.419 RJ and a mass,
MP = 0.60 MJ, yielding a density of 0.26 g cm^-3, among the lowest density
planets known. The orbital period is P = 3.523 days and orbital semima jor axis
is 0.0483+0.0006/-0.0012 AU. The star has a large rotational v sin i of 10.5
+/- 0.7 km s^-1 and is relatively faint (V = 13.89 mag), both properties
deleterious to precise Doppler measurements. The velocities are indeed noisy,
with scatter of 30 m s^-1, but exhibit a period and phase consistent with the
planet implied by the photometry. We securely detect the Rossiter-McLaughlin
effect, confirming the planet's existence and establishing its orbit as
prograde. We measure an inclination between the projected planetary orbital
axis and the projected stellar rotation axis of lambda = -26.9 +/- 4.6 deg,
indicating a moderate inclination of the planetary orbit. Rossiter-McLaughlin
measurements of a large sample of transiting planets from Kepler will provide a
statistically robust measure of the true distribution of spin-orbit
orientations for hot jupiters in general.Comment: 26 pages, 8 figures, 2 tables; In preparation for submission to the
Astrophysical Journa
Circumstellar discs: What will be next?
This prospective chapter gives our view on the evolution of the study of
circumstellar discs within the next 20 years from both observational and
theoretical sides. We first present the expected improvements in our knowledge
of protoplanetary discs as for their masses, sizes, chemistry, the presence of
planets as well as the evolutionary processes shaping these discs. We then
explore the older debris disc stage and explain what will be learnt concerning
their birth, the intrinsic links between these discs and planets, the hot dust
and the gas detected around main sequence stars as well as discs around white
dwarfs.Comment: invited review; comments welcome (32 pages
Characteristics of Kepler Planetary Candidates Based on the First Data Set: The Majority are Found to be Neptune-Size and Smaller
In the spring of 2009, the Kepler Mission commenced high-precision photometry
on nearly 156,000 stars to determine the frequency and characteristics of small
exoplanets, conduct a guest observer program, and obtain asteroseismic data on
a wide variety of stars. On 15 June 2010 the Kepler Mission released data from
the first quarter of observations. At the time of this publication, 706 stars
from this first data set have exoplanet candidates with sizes from as small as
that of the Earth to larger than that of Jupiter. Here we give the identity and
characteristics of 306 released stars with planetary candidates. Data for the
remaining 400 stars with planetary candidates will be released in February
2011. Over half the candidates on the released list have radii less than half
that of Jupiter. The released stars include five possible multi-planet systems.
One of these has two Neptune-size (2.3 and 2.5 Earth-radius) candidates with
near-resonant periods.Comment: Paper to accompany Kepler's June 15, 2010 data release; submitted to
Astrophysical Journal Figures 1,2,& 3 revised. Improved labeling on all
figures. Slight changes to planet frequencies in result
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