Modeling Quantum Optical Components, Pulses and Fiber Channels Using OMNeT++

Quantum Key Distribution (QKD) is an innovative technology which exploits the laws of quantum mechanics to generate and distribute unconditionally secure cryptographic keys. While QKD offers the promise of unconditionally secure key distribution, real world systems are built from non-ideal components which necessitates the need to model and understand the impact these non-idealities have on system performance and security. OMNeT++ has been used as a basis to develop a simulation framework to support this endeavor. This framework, referred to as "qkdX" extends OMNeT++'s module and message abstractions to efficiently model optical components, optical pulses, operating protocols and processes. This paper presents the design of this framework including how OMNeT++'s abstractions have been utilized to model quantum optical components, optical pulses, fiber and free space channels. Furthermore, from our toolbox of created components, we present various notional and real QKD systems, which have been studied and analyzed.Comment: Published in: A. F\"orster, C. Minkenberg, G. R. Herrera, M. Kirsche (Eds.), Proc. of the 2nd OMNeT++ Community Summit, IBM Research - Zurich, Switzerland, September 3-4, 201

Fluorination Enables a Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones

This is the peer reviewed version of the following article: Yang, M., Orsi, D. L., & Altman, R. A. (2015). Fluorination Enables a Ligand-Controlled Regiodivergent Palladium-Catalyzed Decarboxylative Allylation Reaction to Access α,α-Difluoroketones. Angewandte Chemie (International Ed. in English), 54(8), 2361–2365. http://doi.org/10.1002/anie.201410039, which has been published in final form at doi.org/10.1002/anie.201410039. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.α,α-Difluoroketones possess unique physicochemical properties that are useful for developing therapeutics and probes for chemical biology. In order to access the α-allyl-α,α-difluoroketone substructure, complementary Pd-catalyzed decarboxylative allylation reactions were developed to provide linear and branched α-allyl-α,α-difluoroketones. For these orthogonal processes, the regioselectivity was uniquely controlled by fluorination of the substrate and the structure of ligand

HAVE WE REACHED PEAK DESIGN THINKING? Are we entering a new paradigm for how it is used within practice and business?

Design Thinking has gained recognition as an acclaimed process for generating innovative, human centred solutions at a social and business level. It has also gained notoriety amongst many designers, who claim that its success as an exported element of the design process has resulted in its commodification, and led to it becoming a diluted series of processes that lack criticality. As design disciplines and the role of designers continue to evolve, we should reflect on design thinking’s original context and understand its progression into a non-design world. Our hypothesis is that design thinking has reached a ‘peak’ in contemporary practice, and as the term 'design' is further adapted and conformed to suit a business function, this conversational will elicit a constructive debate on the future of design thinking and its positioning within design and non-design industries. Has Design Thinking’s commodification and consumption as a step by step road map to innovation reduced it to a mainstream approach? Can we use the undoubted successes of design thinking as a catalyst for future design research? It is anticipated that through analysis and discussion, this conversation will inform the conceptualisation of enhanced methodological frameworks that aim to support innovation across divergent industry practices

Patient-Reported Outcomes Measurement Information System physical function correlates with Toronto Extremity Salvage Score in an orthopaedic oncology population

Background: The National Institute of Health\u27s Patient-Reported Outcomes Measurement Information System (PROMIS) uses computerised-adaptive testing to reduce survey burden and improve sensitivity. PROMIS is being used across medical and surgical disciplines but has not been studied in orthopaedic oncology. Questions/purposes: The aim of the study was to compare PROMIS measures with upper extremity (UE) and lower extremity (LE) Toronto Extremity Salvage Score (TESS) by assessing the following: (1) responder burden, (2) correlation between scores and (3) floor/ceiling effects. Patients and methods: This cross-sectional trial analysed all 97 adult patients treated surgically for a bone or soft tissue tumour at a tertiary institution between November 2015 and March 2016. TESS (UE or LE) and PROMIS (Physical Function, Pain Interference and Depression) surveys were administered preoperatively. Pearson correlations between each PROMIS domain and TESS were calculated, as were floor/ceiling effects of each outcome measure. Results: (1) Completion of three PROMIS questionnaires required a mean total of 16.8 (+/- 5.8 standard deviation) questions, compared with 31 and 32 questions for the LE and UE TESS questionnaires, respectively. (2) The PROMIS Physical Function scores demonstrated a strong positive correlation with the LE TESS (r = 0.84; 95% confidence interval [CI], 0.72-0.91; p \u3c 0.001) and moderate positive correlation with the UE TESS (r = 0.64; 95% CI, 0.34-0.83; p = 0.055). The PROMIS Depression scores demonstrated a weak negative correlation with both the LE TESS (r = -0.38; 95% CI, -0.61 to -0.10; p = 0.010) and with UE TESS (r = -0.38; 95% CI, -0.67 to -0.01; p = 0.055). The PROMIS Pain Interference scores demonstrated a strong negative correlation with the LE TESS (r = -0.71; 95% CI, -0.83 to -0.52; p \u3c 0.001) and a moderate negative correlation with the UE TESS (r = -0.62; 95% CI, -0.81 to -0.30; p = 0.001). (3) The UE TESS had a range of scores from 16 to 100 with a 27% ceiling effect and no floor effect, and the LE TESS had a range from 10 to 98 with no floor or ceiling effect. There was no floor or ceiling effect for any PROMIS measures. Conclusions: In an orthopaedic oncology population, the PROMIS Physical Function and Pain Interference scores correlate with the TESS and have the benefit of reduced survey burden and ceiling effect. The PROMIS Depression scores may provide additional information regarding patient outcomes not captured by the TESS. Level of Evidence: Level III. The translational potential of this article: Patient reported outcome measures asses patients\u27 symptoms, function and health-related quality of life and are designed to capture more clinical information than can be gathered by objective medial testing alone. As reimbursements and the understanding of patient outcomes are becoming tied to performance on PROMIS measures, it is an important step to establish how PROMIS measures correlate and compare to traditional legacy measures

Agreement between methods of measurement with multiple observations per individual

Limits of agreement provide a straightforward and intuitive approach to agreement between different methods for measuring the same quantity. When pairs of observations using the two methods are independent, i.e., on different subjects, the calculations are very simple and straightforward. Some authors collect repeated data, either as repeated pairs of measurements on the same subject, whose true value of the measured quantity may be changing, or more than one measurement by one or both methods of an unchanging underlying quantity. In this paper we describe methods for analysing such clustered observations, both when the underlying quantity is assumed to be changing and when it is not

Optical Identification of Cepheids in 19 Host Galaxies of Type Ia Supernovae and NGC 4258 with the Hubble Space Telescope

We present results of an optical search for Cepheid variable stars using the Hubble Space Telescope (HST) in 19 hosts of Type Ia supernovae (SNe Ia) and the maser-host galaxy NGC 4258, conducted as part of the SH0ES project (Supernovae and H0 for the Equation of State of dark energy). The targets include 9 newly imaged SN Ia hosts using a novel strategy based on a long-pass filter that minimizes the number of HST orbits required to detect and accurately determine Cepheid properties. We carried out a homogeneous reduction and analysis of all observations, including new universal variability searches in all SN Ia hosts, that yielded a total of 2200 variables with well-defined selection criteria -- the largest such sample identified outside the Local Group. These objects are used in a companion paper to determine the local value of H0 with a total uncertainty of 2.4%.Comment: ApJ, in press. v2 adds missing co-author to arXiv metadata and text in acknowledgment

Overview of Instruments for Investigating Dust Interactions on Small Solar System Bodies by Landers and Rovers

Small Solar System bodies such as asteroids, comets and Mars\u27 moons Phobos and Deimos have relatively unknown regolith environments. It is hypothesized that dust preserved in the regolith on the surfaces will have similar mechanical properties to lunar dust because of similar formation processes from micrometeoric bombardment, low relative gravity for slow settling times, and virtually no weathering because there is no atmosphere

Barchan-Parabolic Dune Pattern Transition From Vegetation Stability Threshold

Many dune fields exhibit a downwind transition from forward-pointing barchan dunes to stabilized, backward-pointing parabolic dunes, accompanied by an increase in vegetation. A recent model predicts this pattern transition occurs when dune surface erosion/deposition rates decrease below a threshold of half the vegetation growth rate. We provide a direct test using a unique data set of repeat topographic surveys across White Sands Dune Field and find strong quantitative support for the model threshold. We also show the threshold hypothesis applied to a barchan dune results naturally in its curvature inversion, as the point of threshold crossing progresses from the horns to the crest. This simple, general threshold framework can be an extremely useful tool for predicting the response of dune landscapes to changes in wind speed, sediment supply, or vegetation growth rate. Near the threshold, a small environmental change could result in a drastic change in dune pattern and activity

Association of Systemic Inflammation With Retinal Vascular Caliber in Patients With AIDS.

PurposeTo evaluate relationships among retinal vascular caliber and biomarkers of systemic inflammation in patients with AIDS.MethodsA total of 454 participants with AIDS had retinal vascular caliber (central retinal artery equivalent and central retinal vein equivalent) determined from enrollment retinal photographs by reading center graders masked to clinical and biomarker information. Cryopreserved plasma specimens were assayed for inflammatory biomarkers, including C-reactive protein (CRP), IL-6, interferon-γ inducible protein (IP)-10, kynurenine/tryptophan (KT) ratio, and intestinal fatty acid binding protein (I-FABP).ResultsIn the simple linear regression of retinal vascular caliber on plasma biomarkers, elevated CRP, IL-6, and IP-10 were associated with retinal venular dilation, and elevated KT ratio with retinal arteriolar narrowing. In the multiple linear regression, including baseline characteristics and plasma biomarkers, AMD was associated with dilation of retinal arterioles (mean difference: 9.1 μm; 95% confidence interval [CI] 5.2, 12.9; P < 0.001) and venules (mean difference, 10.9 μm; 95% CI, 5.3, 16.6; P < 0.001), as was black race (P < 0.001). Hyperlipidemia was associated with retinal venular narrowing (mean difference, -7.5 μm; 95% CI, -13.7, -1.2; P = 0.02); cardiovascular disease with arteriolar narrowing (mean difference, -5.2 μm; 95% CI, -10.3, -0.1; P = 0.05); age with arteriolar narrowing (slope, -0.26 μm/year; 95% CI, -0.46, -0.06; P = 0.009); and IL-6 with venular dilation (slope, 5.3 μm/standard deviation log10[plasma IL-6 concentration]; 95% CI, 2.7, 8.0; P < 0.001).ConclusionsThese data suggest that retinal vascular caliber is associated with age, race, AMD, hyperlipidemia, cardiovascular disease, and selected biomarkers of systemic inflammation