Loop Equations and the Topological Phase of Multi-Cut Matrix Models

We study the double scaling limit of mKdV type, realized in the two-cut Hermitian matrix model. Building on the work of Periwal and Shevitz and of Nappi, we find an exact solution including all odd scaling operators, in terms of a hierarchy of flows of $2\times 2$ matrices. We derive from it loop equations which can be expressed as Virasoro constraints on the partition function. We discover a ``pure topological" phase of the theory in which all correlation functions are determined by recursion relations. We also examine macroscopic loop amplitudes, which suggest a relation to 2D gravity coupled to dense polymers.Comment: 24p

Fahrenheit 451: Tempreture Rising

Fahrenheit 451 is acknowledged by many theorists as one of the most symbolic dystopias of the twentieth century, and although the novel has been analyzed extensively with a focus on the influence of mass communication, no study has addressed the hyperreal factors of television in Bradbury\u27s world. Bradbury has expressed his concern about the influence television has on the masses, not only in his fictional dystopia, but in American society today. Television\u27s capability of mass-producing simulacra promotes hyperreality, which results in a distortion of meaning and implosion of reality. This study will use Jean Baudrillard\u27s theory of hyperreality as a frame to examine the influence television has on the world of Fahrenheit 451 and compare it to television\u27s influence in post-modern America, specifically the post-9/11 era. It will address the medium of entertainment, primarily reality TV, to examine how television is used to distort meaning in human relationships, spirituality, and history in both societies. It will also examine how media corporations have taken on many qualities of entertainment programs. The study will also include an analysis of how television has influenced the social and political factors in both societies, and entertain Baudrillard\u27s claim that America can go beyond the imaginary of science fictions novels like Fahrenheit 45

Bayesian Spatiotemporal Pattern and Eco-climatological Drivers of Striped Skunk Rabies in the North Central Plains

Citation: Raghavan, R. K., Hanlon, C. A., Goodin, D. G., Davis, R., Moore, M., Moore, S., & Anderson, G. A. (2016). Bayesian Spatiotemporal Pattern and Eco-climatological Drivers of Striped Skunk Rabies in the North Central Plains. Plos Neglected Tropical Diseases, 10(4), 16. doi:10.1371/journal.pntd.0004632Striped skunks are one of the most important terrestrial reservoirs of rabies virus in North America, and yet the prevalence of rabies among this host is only passively monitored and the disease among this host remains largely unmanaged. Oral vaccination campaigns have not efficiently targeted striped skunks, while periodic spillovers of striped skunk variant viruses to other animals, including some domestic animals, are routinely recorded. In this study we evaluated the spatial and spatio-temporal patterns of infection status among striped skunk cases submitted for rabies testing in the North Central Plains of US in a Bayesian hierarchical framework, and also evaluated potential eco-climatological drivers of such patterns. Two Bayesian hierarchical models were fitted to point-referenced striped skunk rabies cases [n = 656 (negative), and n = 310 (positive)] received at a leading rabies diagnostic facility between the years 2007-2013. The first model included only spatial and temporal terms and a second covariate model included additional covariates representing eco-climatic conditions within a 4km(2) home-range area for striped skunks. The better performing covariate model indicated the presence of significant spatial and temporal trends in the dataset and identified higher amounts of land covered by low-intensity developed areas [Odds ratio (OR) = 3.41; 95% Bayesian Credible Intervals (CrI) = 2.08, 3.85], higher level of patch fragmentation (OR = 1.70; 95% CrI = 1.25, 2.89), and diurnal temperature range (OR = 0.54; 95% CrI = 0.27, 0.91) to be important drivers of striped skunk rabies incidence in the study area. Model validation statistics indicated satisfactory performance for both models; however, the covariate model fared better. The findings of this study are important in the context of rabies management among striped skunks in North America, and the relevance of physical and climatological factors as risk factors for skunk to human rabies transmission and the space-time patterns of striped skunk rabies are discussed

Enantioselective Construction of Acyclic Quaternary Carbon Stereocenters: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully-Substituted Amide Enolates

We report a divergent and modular protocol for the preparation of acyclic molecular frameworks containing newly created quaternary carbon stereocenters. Central to this approach is a sequence composed of a (1) regioselective and -retentive preparation of allyloxycarbonyl-trapped fully substituted stereodefined amide enolates and of a (2) enantioselective palladium-catalyzed decarboxylative allylic alkylation reaction using a novel bisphosphine ligand

A Content Analysis of How Engineering is Assessed in Published Curricula

A Content Analysis of How Engineering is Assessed in Published Curricula (Fundamental) The purpose of this proposal is to present research findings concerning how and what about engineering is commonly assessed in well-known engineering or integrated STEM published curriculum. Two of the major shifts brought about by Next Generation Science Standards (NGSS) are an increased emphasis in students’ capabilities to perform higher-level reasoning skills and integrate content understanding into science practices. At the same time, NGSS has made engineering integration into science education a priority, and it is an exciting time of reform as schools are exploring curriculum resources and teachers are being trained in engineering design. When engineering is a part of science instruction, there must also be corresponding measurement of student learning, yet many teachers who are new to engineering are also unfamiliar with the process of assessing design practices. In addition, teachers must grapple with how to assess higher order skills, including how students use science to make design decisions. Evidence of higher levels of learning beyond memorizing content or identifying facts is the goal of engineering assessment, and NGSS provides general patterns of thought and behavior that students may exhibit at each grade level related to defining problems, developing solutions, and optimizing results which demonstrate learning. However, these guidelines are very broad and do not clearly recommend ways to go about assessing these practices in the classroom. It is imperative that teachers are provided with the means to properly assess student learning of both content and engineering practices. As part of a larger goal of developing an integrated STEM curriculum for grades 4 – 8, this content analysis addresses the need for questioning how engineering is commonly assessed in elementary engineering or integrated STEM curricula. By examining current STEM assessments with two frameworks, this study investigates the following research questions: (1) What aspects of engineering are being assessed in common engineering or integrated STEM curricular units? (2) What level of cognitive demand is being referenced by these assessments? Using a purposeful sampling strategy, the authors reviewed 15 engineering curricula units published by 3 different publishing companies. To address the research questions, assessment tasks were coded based on the Task Analysis Guide in Science (TAGS) framework and alignment to the engineering process of design (POD). Preliminary results show that the majority of integrated STEM assessment items are testing students on memorized engineering practice, and very few are referencing higher levels of cognitive demand. These results indicate that the more complex thinking that students use during engineering classroom learning is being overlooked by subsequent assessment. In addition, a large proportion of assessment items are dedicated to learning background information about the problem and planning solution ideas, compared with other steps in the design process. The full paper will discuss conclusions and implications of the study

Probing Trends in Enantioinduction via Substrate Design: Palladium-Catalyzed Decarboxylative Allylic Alkylation of α-Enaminones

Herein, we report the palladium-catalyzed decarboxylative asymmetric allylic alkylation of α-enaminones. In addition to serving as valuable synthetic building blocks, we exploit the α-enaminone scaffold and its derivatives as probes to highlight structural and electronic factors that govern enantioselectivity in this asymmetric alkylation reaction. Utilizing the (S)-t-BuPHOX ligand in a variety of nonpolar solvents, the alkylated products are obtained in up to 99% yield and 99% enantiomeric excess

N=1 gauge superpotentials from supergravity

We review the supergravity derivation of some non-perturbatively generated effective superpotentials for N=1 gauge theories. Specifically, we derive the Veneziano-Yankielowicz superpotential for pure N=1 Super Yang-Mills theory from the warped deformed conifold solution, and the Affleck-Dine-Seiberg superpotential for N=1 SQCD from a solution describing fractional D3-branes on a C^3 / Z_2 x Z_2 orbifold.Comment: LaTeX, iopart class, 8 pages, 3 figures. Contribution to the proceedings of the workshop of the RTN Network "The quantum structure of space-time and the geometric nature of fundamental interactions", Copenhagen, September 2003; v2: published version with minor clarification

Three-dimensional ring current decay model

This work is an extension of a previous ring current decay model. In the previous work, a two-dimensional kinetic model was constructed to study the temporal variations of the equatorially mirroring ring current ions, considering charge exchange and Coulomb drag losses along drift paths in a magnetic dipole field. In this work, particles with arbitrary pitch angle are considered. By bounce averaging the kinetic equation of the phase space density, information along magnetic field lines can be inferred from the equator. The three-dimensional model is used to simulate the recovery phase of a model great magnetic storm, similar to that which occurred in early February 1986. The initial distribution of ring current ions (at the minimum Dst) is extrapolated to all local times from AMPTE/CCE spacecraft observations on the dawnside and duskside of the inner magnetosphere spanning the L value range L = 2.25 to 6.75. Observations by AMPTE/CCE of ring current distributions over subsequent orbits during the storm recovery phase are compared to model outputs. In general, the calculated ion fluxes are consistent with observations, except for H(+) fluxes at tens of keV, which are always overestimated. A newly invented visualization idea, designated as a chromogram, is used to display the spatial and energy dependence of the ring current ion differential flux. Important features of storm time ring current, such as day-night asymmetry during injection and drift hole on the dayside at low energies (less than 10 keV), are manifested in the chromogram representation. The pitch angle distribution is well fit by the function, J(sub o)(1 + Ay(sup n)), where y is sine of the equatorial pitch angle. The evolution of the index n is a combined effect of charge exchange loss and particle drift. At low energies (less than 30 keV), both drift dispersion and charge exchange are important in determining n

Differential expression of type X collagen in a mechanically active 3-D chondrocyte culture system: a quantitative study

OBJECTIVE: Mechanical loading of cartilage influences chondrocyte metabolism and gene expression. The gene encoding type X collagen is expressed specifically by hypertrophic chondrocytes and up regulated during osteoarthritis. In this study we tested the hypothesis that the mechanical microenvironment resulting from higher levels of local strain in a three dimensional cell culture construct would lead to an increase in the expression of type X collagen mRNA by chondrocytes in those areas. METHODS: Hypertrophic chondrocytes were isolated from embryonic chick sterna and seeded onto rectangular Gelfoam sponges. Seeded sponges were subjected to various levels of cyclic uniaxial tensile strains at 1 Hz with the computer-controlled Bio-Stretch system. Strain distribution across the sponge was quantified by digital image analysis. After mechanical loading, sponges were cut and the end and center regions were separated according to construct strain distribution. Total RNA was extracted from the cells harvested from these regions, and real-time quantitative RT-PCR was performed to quantify mRNA levels for type X collagen and a housing-keeping gene 18S RNA. RESULTS: Chondrocytes distributed in high (9%) local strain areas produced more than two times type X collagen mRNA compared to the those under no load conditions, while chondrocytes located in low (2.5%) local strain areas had no appreciable difference in type X collagen mRNA production in comparison to non-loaded samples. Increasing local strains above 2.5%, either in the center or end regions of the sponge, resulted in increased expression of Col X mRNA by chondrocytes in that region. CONCLUSION: These findings suggest that the threshold of chondrocyte sensitivity to inducing type X collagen mRNA production is more than 2.5% local strain, and that increased local strains above the threshold results in an increase of Col X mRNA expression. Such quantitative analysis has important implications for our understanding of mechanosensitivity of cartilage and mechanical regulation of chondrocyte gene expression