2,794 research outputs found
Landau-Ginzburg Description of D-branes on ALE Spaces
We study the Landau-Ginzburg (LG) mirror theory of the non-linear sigma model
on the ALE space obtained by resolving the singularity of the
orbifold . In the LG description, the data of the BPS
spectrum and the lines of marginal stability are encoded in the special
Lagrangian submanifolds of the mirror manifold . Our LG
description is quite simple as compared with the quiver gauge theory analysis
near the orbifold point. Furthermore our mirror analysis can be applied to any
point on the moduli space of .Comment: 24 pages, 6 figures, reference added, typos correcte
Eight Dimensional Noncommutative Instantons and D0-D8 Bound States with B-field
We construct some classes of instanton solutions of eight dimensional
noncommutative ADHM equations generalizing the solutions of eight dimensional
commutative ADHM equations found by Papadopoulos and Teschendorff, and
interpret them as supersymmetric - bound states in a NS -field.
Especially, we consider the - system with anti-self-dual -field
preserving 3/16 of supercharges. This system and self-duality conditions are
related with the group which is a subgroup of the eight dimensional
rotation group SO(8).Comment: 13 page
Stability and BPS branes
We define the concept of Pi-stability, a generalization of mu-stability of
vector bundles, and argue that it characterizes N=1 supersymmetric brane
configurations and BPS states in very general string theory compactifications
with N=2 supersymmetry in four dimensions.Comment: harvmac, 18 p
Flying Beyond the Stall: The X-31 and the Advent of Supermaneuverability
This is the story of a unique research airplane-unique because the airplane and the programs that supported it did things that have never been done before or since. The major purpose of this book is to tell the story of NASA's role in the X-31 program. In order to do this, though, it is necessary to put NASA's participation in perspective with the other phases of the program, namely the genesis of the concept, the design and fabrication of the aircraft, the initial flight testing done without NASA participation, the flight testing done with NASA participation, and the subsequent Navy X-31 Vectoring ESTOL (extreme short takeoff and landings) Control Operation Research (VECTOR) program
Stability conditions and Stokes factors
Let A be the category of modules over a complex, finite-dimensional algebra.
We show that the space of stability conditions on A parametrises an
isomonodromic family of irregular connections on P^1 with values in the Hall
algebra of A. The residues of these connections are given by the holomorphic
generating function for counting invariants in A constructed by D. Joyce.Comment: Very minor changes. Final version. To appear in Inventione
Comorbidity and Quality of Life in Adults with Hair Pulling Disorder
Hair pulling disorder (HPD; trichotillomania) is thought to be associated with significant psychiatric comorbidity and functional impairment. However, few methodologically rigorous studies of HPD have been conducted, rendering such conclusions tenuous. The following study examined comorbidity and psychosocial functioning in a well-characterized sample of adults with HPD (N=85) who met DSM-IV criteria, had at least moderate hair pulling severity, and participated in a clinical trial. Results revealed that 38.8% of individuals with HPD had another current psychiatric diagnosis and 78.8% had another lifetime (present and/or past) psychiatric diagnosis. Specifically, HPD showed substantial overlap with depressive, anxiety, addictive, and other body-focused repetitive behavior disorders. The relationships between certain comorbidity patterns, hair pulling severity, current mood and anxiety symptoms, and quality of life were also examined. Results showed that current depressive symptoms were the only predictor of quality of life deficits. Implications of these findings for the conceptualization and treatment of HPD are discussed
A Note on Fluxes in Six-Dimensional String Theory Backgrounds
We study the structure of warped compactifications of type IIB string theory
to six space-time dimensions. We find that the most general four-manifold
describing the internal dimensions is conformal to a Kahler manifold, in
contrast with the heterotic case where the four-manifold must be conformally
Calabi-Yau.Comment: 22 pages, phyzz
A Conserved HPD Sequence of the J-domain Is Necessary for YDJ1 Stimulation of Hsp70 ATPase Activity at a Site Distinct from Substrate Binding
The 46-kDa protein YDJ1 is one of several known yeast homologues of the Escherichia coli DnaJ protein. Like all J homologues, it shares homology with the highly conserved NH2-terminal "J-domain" of DnaJ. A component of the DnaK (Hsp70) chaperone machinery that mediates protein folding, DnaJ is necessary for survival at elevated temperatures. It stimulates ATP hydrolysis by DnaK and effects the release of DnaK-bound polypeptides. Previous genetic and biochemical studies indicate that the J-domain is necessary for these functions. Using peptides corresponding to J-domain sequence, we show that a peptide containing the highly conserved His-Pro-Asp sequence at positions 34-36 in the J-domain competes off YDJ1 stimulation of Hsp70 ATPase activity. Inhibitory concentrations of peptide do not prevent binding of folding substrates, therefore YDJ1 must interact with Hsp70 at a site distinct from that for substrate binding. This interaction is critical for Hsp70 activity, since a mutant YDJ1 protein harboring a H34Q change (ydj1Q34) stimulates neither Hsp70 ATPase nor substrate release. The importance of the proper function of this region of the protein is supported by the poor growth and temperature-sensitive phenotype of yeast expressing ydj1Q34
Association of combination statin and antihypertensive therapy with reduced Alzheimer’s disease and related dementia risk
Background Hyperlipidemia and hypertension are modifiable risk factors for Alzheimer's disease and related dementias (ADRD). Approximately 25% of adults over age 65 use both antihypertensives (AHTs) and statins for these conditions. While a growing body of evidence found statins and AHTs are independently associated with lower ADRD risk, no evidence exists on simultaneous use for different drug class combinations and ADRD risk. Our primary objective was to compare ADRD risk associated with concurrent use of different combinations of statins and antihypertensives. Methods In a retrospective cohort study (2007-2014), we analyzed 694,672 Medicare beneficiaries in the United States (2,017,786 person-years) who concurrently used both statins and AHTs. Using logistic regression adjusting for age, socioeconomic status and comorbidities, we quantified incident ADRD diagnosis associated with concurrent use of different statin molecules (atorvastatin, pravastatin, rosuvastatin, and simvastatin) and AHT drug classes (two renin-angiotensin system (RAS)-acting AHTs, angiotensin converting enzyme inhibitors (ACEIs) or angiotensin-II receptor blockers (ARBs), vs non-RAS-acting AHTs). Findings Pravastatin or rosuvastatin combined with RAS-acting AHTs reduce risk of ADRD relative to any statin combined with non-RAS-acting AHTs: ACEI+pravastatin odds ratio (OR) = 0.942 (CI: 0.899-0.986, p = 0.011), ACEI+rosuvastatin OR = 0.841 (CI: 0.794-0.892, p< 0.001), ARB+pravastatin OR = 0.794 (CI: 0.748-0.843, p< 0.001), ARB+rosuvastatin OR = 0.818 (CI: 0.765-0.874, p< 0.001). ARBs combined with atorvastatin and simvastatin are associated with smaller reductions in risk, and ACEI with no risk reduction, compared to when combined with pravastatin or rosuvastatin. Among Hispanics, no combination of statins and RAS-acting AHTs reduces risk relative to combinations of statins and non-RAS-acting AHTs. Among blacks using ACEI+rosuvastatin, ADRD odds were 33% lower compared to blacks using other statins combined with non-RAS-acting AHTs (OR = 0.672 (CI: 0.5480.825, p<0.001)). Conclusion Among older Americans, use of pravastatin and rosuvastatin to treat hyperlipidemia is less common than use of simvastatin and atorvastatin, however, in combination with RAS-acting AHTs, particularly ARBs, they may be more effective at reducing risk of ADRD. The number of Americans with ADRD may be reduced with drug treatments for vascular health that also confer effects on ADRD.Open access journalThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
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