An optically pure P-alkene-ligated Ir(I) complex

The asymmetric unit of (P)-chloridobis[(S)-(+)-5-(3,5-dioxa-4-phosphacyclo­hepta­[2,1-a:3,4-a']dinaphthalen-4-yl)dibenz[b,f]azepine]iridium(I)-benzene-pentane (1/1/1), [IrCl(C34H22NO2P)2]·C6H6·C5H12, contains two formula units. The two symmetry-independent mol­ecules of the Ir complex have similar conformations and approximate C2 symmetry, with small deviations arising from slightly different puckering of the seven-membered di­oxa­phospha­cyclo­hepta­di­ene rings. The Ir atoms have trigonal-bipyramidal coordination geometry, with the P atoms in axial positions. The steric strain of the bidentate coordination of the P-alkene ligand through its P and alkene C atoms causes the N atom to have pyramidal geometry, compared with the trigonal-planar geometry observed in the free ligand. The coordination also results in an anti conformation of the binaphthyl and alkene groups within the P-alkene ligand

(Z)-4-(2,5-Di-tert-butyl­anilino)pent-3-en-2-one

In the crystal structure of the title ketoamine, C19H29NO, the bond lengths from the N atom through the alkene group to the ketone O atom show the presence of an extensively delocalized π-system. The dihedral angle between the plane of the phenyl ring and that of the alkene component is 63.45 (7)° due to steric hindrance exerted by the tert-butyl groups. The mol­ecule has a Z-configured alkene function, which is facilitated by an intra­molecular N—H⋯O hydrogen bond between the amine and ketone groups. The mol­ecules are linked into extended chains, which run parallel to the [010] direction, by a very weak C—H⋯O inter­action between the methyl substituent of the alkene group and the ketone O atom of a neighbouring mol­ecule

Chiral (SO)–N–(SO) Sulfoxide Pincer Complexes of Mg, Rh, and Ir: N–H Activation and Selective Sulfoxide Reduction upon Ligand Coordination

Multigram quantities of the optically pure amino−bis-sulfoxide ligand (S,S)-bis(4-tert-butyl-2-(ptolylsulfinyl) phenyl)amine ((S,S)-3) are accessible by in situ lithiation of bis(2-bromo-4-tert-butylphenyl)amine (1) followed by a nucleophilic displacement reaction with Andersen’s sulfinate 2. Deprotonation of (S,S)-3 with MgPh2 yields the magnesium amido−bis-sulfoxide salt (S,S)-4 quantitatively. Metathetical exchange of (S,S)-4 with [RhCl(COE)2]2 affords the optically pure pseudo-C2-symmetric Rh(I)−amido bissulfoxide pincer complex mer-(R,R)-[Rh(bis(4-(tert-butyl)-2- (p-tolylsulfinyl)phenyl)amide)(COE)] (mer-(R,R)-5). This complex reacts with 3 equiv of HCl to give the facial Rh(III) complex fac-(S,R,R)-[Rh(bis(4-(tert-butyl)-2-(p-tolylsulfinyl)- phenyl)amine)Cl3] (fac-(S,R,R)-6), in which one of the sulfoxide functions has been reduced to the sulfide and in which the resulting sulfoxide−sulfide−amine ligand is facially coordinated. The same complexes 5 and 6 form in a 1:2 ratio in a disproportionation reaction when [RhCl(COE)2]2 is treated with 2 equiv of neutral ligand 3. N−H activation is directly observed in the reaction of [IrCl(COE)2]2 with 3, affording the amido−hydrido−Ir(III) complex [Ir(bis(4-(tert-butyl)-2-(ptolylsulfinyl) phenyl)amide)(Cl)(H)(COE)] (8)

(E)-3-(1-Naphthyl­amino)­methyl­ene-(+)-camphor

In the crystal structure of the title ketoamine {systematic name: (E)-1,7,7-trimethyl-3-[(1-naphthyl­amino)­methyl­idene]bicyclo­[2.2.1]heptan-2-one}, C21H23NO, there are two independent mol­ecules in the asymmetric unit. Both mol­ecules have an E configuration about the alkene function. The main conformational difference between the mol­ecules is in the orientation of the plane of the naphthyl rings with respect to the camphor fragment. The torsion angle about the enamine C—N bond is 21.3 (7)° for mol­ecule A, but −24.4 (8)° for mol­ecule B. Inter­molecular N—H⋯O hydrogen bonds between the amino and ketone groups of adjacent independent mol­ecules sustain the crystal, and the resulting extended chains, containing an alternating sequence of the two independent mol­ecules, run parallel to the [001] direction and can be described by a graph-set motif of C 2 2(12)

Towards enantiopure macrocyclic trans-dinucleating hemilabile P-Alkene ligands: Syntheses, structures, and Chiral Pd-Complexes

Dibenzazepinyl dichlorophosphine 2 reacts with (R,R)-2,3-O-isopropylidene-threitol (3) in $Et2_O$ solution to afford gram-quantities of the enantiopure macrocylic phosphoramidite (all-R)-6, which may be seen as a formal dimer of classic phosphoramidite P-alkene hybrid ligands. Complexation experiments with $PdCl_2$ reveal highly selective formation of the trans-dinuclear complex (all-R)-11. The corresponding bulkier and rigidly trans-eclipsed 1,4-diol (S,S)-bis-hydroximethyl-9,10- dihydro-9,10-ethaneanthracene (4), does not favor macrocycle formation and exclusively leads to the new dibenzazepinyl phsophormaidite P-alkene ligand 7, which in Pd-catalyzed asymmetric allylic amination comes the well-known ‘privileged’ binol-derived P-alkene analogue 1 close in terms of enantioselection

Chiral amino-phosphine and amido-phosphine complexes of Ir and Mg. Catalytic applications in olefin hydroamination

The reactions of rac- and (S,S)-trans-9,10-dihydro-9,10-ethanoanthracene-11,12-diamine (ANDEN) with PClPh2 in the presence of NEt3 yield the chiral amino-phosphine ligands rac-6 and (S,S)-6, respectively, on multi-gram scales. Both forms of 6 react quantitatively with MgPh2 to afford the C2-symmetric, N-bound Mg amidophosphine complexes rac-7 and (S,S)-7. The former crystallizes as a racemic conglomerate, which is a rare occurrence. Mixing (S,S)- or rac-6 with [IrCl(COE)2]2 leads in both cases to the homochiral dinuclear chloro-bridged P-ligated aminophosphine iridium complexes (S,S,S,S)-9 and rac-9 in excellent yields. X-ray quality single crystals only grow as the racemic compound (or ‘true racemate’) rac-9 thanks to its lowered solubility. In the coordinating solvent CH3CN, rac-9 transforms in high yield into mononuclear Ir-complex rac-10. The crystal structures of compounds rac-6, (S,S)-7, rac-9, and rac-10 reveal the ambidentate nature of the P–N function: amide-coordination in the Mg-complex (S,S)-7 and P-chelation of the softer Ir(I) centres in complexes rac-9 and rac-10. Furthermore, the crystal structures show flexible, symmetry lowering seven-membered P-chelate rings in the Ir complexes and a surprising amount of deformation within the ANDEN backbone. The simulation of this deformation by DFT and SCF calculations indicates low energy barriers. (S,S)-7 and (S,S,S,S)-9 catalyze the intra- and intermolecular hydroamination of alkenes, respectively: 5 mol% of (S,S)-7 affords 2-methyl-4,4′-diphenylcyclopentyl amine quantitatively (7% ee), and 2.5 mol% of (S,S,S,S)-9 in the presence of 5.0 mol% co-catalyst (LDA, PhLi, or MgPh2) gives exo-(2-arylamino)bornanes in up to 68% yield and up to 16% ee

(4R)-3-Hydroxy-7-isopropyl-4-methyl-5,6-dihydrobenzofuran-2(4H)-one

In the title compound, alternatively called α-hydroxy-γ-alkylidenebutenolide, C12H16O3, two independent molecules (A and B) crystallize in the asymmetric unit in each of which the 5,6-dihydrobenzo ring has an envelope conformation. The torsion angle along the butadiene chain in the γ-alkylidenebutenolide core is −177.9 (2)° for molecule A and 179.9 (2)° for molecule B. In the crystal, O—H...O hydrogen bonds between hydroxyl and carbonyl groups of adjacent independent molecules form dimers with R22(10) loops

“Chiral-at-Metal” Hemilabile Nickel Complexes with a Latent d¹⁰-ML₂ Configuration: Receiving Substrates with Open Arms

Complexes with highly reactive stereogenic metal centers are of great interest to asymmetric synthesis. Thus, by reacting [Ni­(COD)₂] with 2 equiv of the P-alkene ligand (<i>S</i>)-<b>5</b> ((<i>S</i>)-(+)-<i>N</i>-(3,5-dioxa-4-phosphacyclohepta­[2,1-<i>a</i>;3,4-<i>a</i>′]­dinaphthalen-4-yl)­dibenz­[<i>b</i>,<i>f</i>]­azepine) or (<i>S</i>_<i>P</i><i>,S</i>_<i>C</i>)<i>-</i><b>6</b> ((2<i>S</i>,5<i>S</i>)-(-)-<i>N</i>-(aza-3-oxa-2-phosphabicyclo­[3.3.0]­octan-4-on-2-yl)­dibenz­[<i>b</i>,<i>f</i>]­azepine), the diastereomerically and enantiomerically pure tetrahedral complexes (Δ,<i>S,S</i>)-[Ni­(<b>5</b>-κ<i>P</i>,η²-alkene)₂] (<b>2a</b>) and (Δ,<i>S</i>_P<i>,S</i>_C<i>,S</i>_P<i>′</i><i>,S</i>_C<i>′</i>)-[Ni­(<b>6</b>-κ<i>P</i>,η²-alkene)₂] (<b>2b</b>) were obtained in almost quantitative yields on multigram scales. The Ni atoms showed in both cases stable Δ configurations. Even though these Ni(0) complexes were air stable in the solid state, once dissolved, complex <b>2a</b> readily activated CS₂, alkynes, and enones as the formal d¹⁰-ML₂ fragment [Ni­(<b>5</b>-κ<i>P</i>)₂] (<b>4</b>) to form adducts <b>8</b>–<b>11</b>. This is possible thanks to the decoordination of the hemilabile alkene arms of the P-alkene ligands, and the X-ray crystal structures of the CS₂ and 4-ethynyltoluene adducts confirmed the η² coordination modes of the substrates and the concomitant opening up of the alkene arms of ligand <b>5</b>. The coordination of α,β-unsaturated carbonyl compounds in complexes <b>11a</b>–<b>c</b> was reversible

1,2,4,5-Benzenetetracarboxylic acid: A versatile hydrogen bonding template for controlling the regioselective topochemical synthesis of head-to-tail photodimers from stilbazole derivatives

The crystal engineering of hydrogen bonded organic assemblies based on 1,2,4,5-benzenetetracarboxylic acid (H4bta) and stilbazole derivatives (1-10) is exploited to provide regio-controlled [2 + 2] photocycloadditions in the solid state. Single crystal X-ray diffraction analyses have revealed that all the arrays are built-up from the self-assembly of the (H2bta)2- dianion with two stilbazolium cations via O-H⋯O- and N+-H⋯O- charge-assisted H-bonding synthons: (4-Hstilbazolium+)2(H2bta2-). The dianion displays an interesting diversity of H-bonding motifs. Such structural flexibility allowed us to obtain four structure-types defined by the preferential formation of intramolecular or intermolecular hydrogen bonds between carboxylate-carboxylic groups. In these ionic assemblies two predominant structural H-bonding patterns were observed. The first pattern is characterised by the formation of intramolecular H-bonds in the dianion, leading to discrete assemblies based on ternary arrays. The second hydrogen pattern consists of 2-D hydrogen networks built-up from the self-assembly of anions via intermolecular H-bonds that are linked to the cations. Two additional examples, in which the dianion is self-assembled in two types of ribbons, were also observed. Another supramolecular feature predominant in all these arrays is the stacking of the cations in a head-to-tail fashion, which is controlled via cation-π interactions. These arrays are photoactive in the solid state upon UV-irradiation leading to the regioselective synthesis of rctt-cyclobutane head-to-tail-isomers in high to quantitative yield. In this work, the template tolerance either to steric or electronic effects by changing the number or positions of the supramolecular interactions exerted by distinctive functional groups was also explored. In addition, assemblies bearing 2-chloro (7 and 8) and 3-chloro-4-stilbazole (1 and 9) crystallize in two different crystalline forms, leading to novel examples of supramolecular isomers with similar solid state reactivity.Fil: Ortega Moreno, Gabriela Andreines. Instituto Venezolano de Investigaciones Científicas; Venezuela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Investigaciones en Tecnología Química. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Investigaciones en Tecnología Química; ArgentinaFil: Hernández, Jesús. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: González, Teresa. Instituto Venezolano de Investigaciones Científicas; VenezuelaFil: Dorta, Romano. Universitat Erlangen-Nuremberg; AlemaniaFil: Briceño, Alexander. Instituto Venezolano de Investigaciones Científicas; Venezuel