The drive system of the Major Atmospheric Gamma-ray Imaging Cherenkov Telescope

The MAGIC telescope is an imaging atmospheric Cherenkov telescope, designed to observe very high energy gamma-rays while achieving a low energy threshold. One of the key science goals is fast follow-up of the enigmatic and short lived gamma-ray bursts. The drive system for the telescope has to meet two basic demands: (1) During normal observations, the 72-ton telescope has to be positioned accurately, and has to track a given sky position with high precision at a typical rotational speed in the order of one revolution per day. (2) For successfully observing GRB prompt emission and afterglows, it has to be powerful enough to position to an arbitrary point on the sky within a few ten seconds and commence normal tracking immediately thereafter. To meet these requirements, the implementation and realization of the drive system relies strongly on standard industry components to ensure robustness and reliability. In this paper, we describe the mechanical setup, the drive control and the calibration of the pointing, as well as present measurements of the accuracy of the system. We show that the drive system is mechanically able to operate the motors with an accuracy even better than the feedback values from the axes. In the context of future projects, envisaging telescope arrays comprising about 100 individual instruments, the robustness and scalability of the concept is emphasized.Comment: 15 pages, 12 (10) figures, submitted to Astroparticle Physics, a high resolution version of the paper (particularly fig. 1) is available at http://publications.mppmu.mpg.de/2008/MPP-2008-101/FullText.pd

Entangling strings of neutral atoms in 1D atomic pipeline structures

We study a string of neutral atoms with nearest neighbor interaction in a 1D beam splitter configuration, where the longitudinal motion is controlled by a moving optical lattice potential. The dynamics of the atoms crossing the beam splitter maps to a 1D spin model with controllable time dependent parameters, which allows the creation of maximally entangled states of atoms by crossing a quantum phase transition. Furthermore, we show that this system realizes protected quantum memory, and we discuss the implementation of one- and two-qubit gates in this setup.Comment: 4 pages, REVTEX, revised version: improvements in introduction and figure

Entangled states of trapped ions allow measuring the magnetic field gradient of a single atomic spin

Using trapped ions in an entangled state we propose detecting a magnetic dipole of a single atom at distance of a few $\mu$m. This requires a measurement of the magnetic field gradient at a level of about 10$^{-13}$ Tesla/$\mu$m. We discuss applications e.g. in determining a wide variation of ionic magnetic moments, for investigating the magnetic substructure of ions with a level structure not accessible for optical cooling and detection,and for studying exotic or rare ions, and molecular ions. The scheme may also be used for measureing spin imbalances of neutral atoms or atomic ensembles trapped by optical dipole forces. As the proposed method relies on techniques well established in ion trap quantum information processing it is within reach of current technology.Comment: 4 pages, 2 fi

Quantum computations with atoms in optical lattices: marker qubits and molecular interactions

We develop a scheme for quantum computation with neutral atoms, based on the concept of "marker" atoms, i.e., auxiliary atoms that can be efficiently transported in state-independent periodic external traps to operate quantum gates between physically distant qubits. This allows for relaxing a number of experimental constraints for quantum computation with neutral atoms in microscopic potential, including single-atom laser addressability. We discuss the advantages of this approach in a concrete physical scenario involving molecular interactions.Comment: 15 pages, 14 figure

A single trapped atom in front of an oscillating mirror

We investigate the Wigner-Weisskopf decay of a two level atom in front of an oscillating mirror. This work builds on and extends previous theoretical and experimental studies of the effects of a static mirror on spontaneous decay and resonance fluorescence. The spontaneously emitted field is inherently non-stationary due to the time-dependent boundary conditions and in order to study its spectral distribution we employ the operational definition of the spectrum of non-stationary light due to the seminal work by Eberly and Wodkiewicz. We find a rich dependence of this spectrum as well as of the effective decay rates and level shifts on the mirror-atom distance and on the amplitude and frequency of oscillations of the mirror. The results presented here provide the basis for future studies of more complex setups, where the motion of the atom and/or the mirror are included as quantum degrees of freedom.Comment: 10 pages, 12 figures, contribution to the special issue in Optics Communications devoted to Krzysztof Wodkiewicz's memor

Genomic and Phenotypic Characterization of Clostridium botulinum Isolates from an Infant Botulism Case Suggests Adaptation Signatures to the Gut

In early life, the immature human gut microbiota is prone to colonization by pathogens that are usually outcompeted by mature microbiota in the adult gut. Colonization and neurotoxin production by a vegetative Clostridium botulinum culture in the gut of an infant can lead to flaccid paralysis, resulting in a clinical outcome known as infant botulism, a potentially life-threatening condition. Beside host factors, little is known of the ecology, colonization, and adaptation of C. botulinum to the gut environment. In our previous report, an infant with intestinal botulism was shown to be colonized by neurotoxigenic C. botulinum culture for 7 months. In an effort to gain ecological and evolutionary insights into this unusually long gut colonization by C. botulinum, we analyzed and compared the genomes of C. botulinum isolates recovered from the infant feces during the course of intoxication and isolates from the infant household dust. A number of observed mutations and genomic alterations pinpointed at phenotypic traits that may have promoted colonization and adaptation to the gut environment and to the host. These traits include motility, quorum-sensing, sporulation, and carbohydrate metabolism. We provide novel perspectives and suggest a tentative model of the pathogenesis of C. botulinum in infant botulism. IMPORTANCE While the clinical aspects of infant botulism and the mode of action of BoNT have been thoroughly investigated, little is known on the pathogenesis and adaptive mechanisms of C. botulinum in the gut. Here, we provide for the first time a comprehensive view on the genomic dynamics and plasticity of C. botulinum over time in a case of infant botulism. The genomic and phenotypic analysis of C. botulinum isolates collected during the disease course offers an unprecedented view of C. botulinum ecology, evolution, and pathogenesis and may be instrumental in developing novel strategies for prevention and treatment of toxicoinfectious botulism. While the clinical aspects of infant botulism and the mode of action of BoNT have been thoroughly investigated, little is known on the pathogenesis and adaptive mechanisms of C. botulinum in the gut. Here, we provide for the first time a comprehensive view on the genomic dynamics and plasticity of C. botulinum over time in a case of infant botulism.Peer reviewe

Dynamically stabilized decoherence-free states in non-Markovian open fermionic systems

Decoherence-free subspaces (DFSs) provide a strategy for protecting the dynamics of an open system from decoherence induced by the system-environment interaction. So far, DFSs have been primarily studied in the framework of Markovian master equations. In this work, we study decoherence-free (DF) states in the general setting of a non-Markovian fermionic environment. We identify the DF states by diagonalizing the non-unitary evolution operator for a two-level fermionic system attached to an electron reservoir. By solving the exact master equation, we show that DF states can be stabilized dynamically.Comment: 11 pages, 3 figures. Any comments are welcom

Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid

Botulinum neurotoxins (BoNTs), produced by the spore-forming bacterium Clostridium botulinum, cause botulism, a rare but fatal illness affecting humans and animals. Despite causing a life-threatening disease, BoNT is a multipurpose therapeutic. Nevertheless, as the most potent natural toxin, BoNT is classified as a Select Agent in the US, placing C. botulinum research under stringent governmental regulations. The extreme toxicity of BoNT, its impact on public safety, and its diverse therapeutic applications urge to devise safe solutions to expand C. botulinum research. Accordingly, we exploited CRISPR/Cas9-mediated genome editing to introduce inactivating point mutations into chromosomal bont/e gene of C. botulinum Beluga E. The resulting Beluga Ei strain displays unchanged physiology and produces inactive BoNT (BoNT/Ei) recognized in serological assays, but lacking biological activity detectable ex- and in vivo. Neither native single-chain, nor trypsinized di-chain form of BoNT/Ei show in vivo toxicity, even if isolated from Beluga Ei sub-cultured for 25 generations. Beluga Ei strain constitutes a safe alternative for the BoNT research necessary for public health risk management, the development of food preservation strategies, understanding toxinogenesis, and for structural BoNT studies. The example of Beluga Ei generation serves as template for future development of C. botulinum producing different inactive BoNT serotypes.Peer reviewe