SÍNDROME METABÓLICA NA GRAVIDEZ COMO FACTOR PREDITIVO DE OUTCOMES OBSTÉTRICOS E NEONATAIS ADVERSOS

O reconhecimento da Síndrome Metabólica (SM) durante a gravidez poderá ajudar a identificar um conjunto de mulheres que não só terão um risco aumentado para desenvolver complicações cardiovasculares e metabólicas mais tardiamente na vida, mas também, potencialmente, estarão em risco de desenvolver uma patologia relacionada com a gravidez. A implementação do rastreio da SM, na segunda metade da gravidez, poderá permitir identificar grávidas de alto risco e definir estratégias de intervenção adequadas. Este trabalho teve como objectivos (i) Determinar a prevalência de SM em gestações normais e complicadas; (ii) Avaliar o impacto do diagnóstico de SM na ocorrência de outcomes obstétricos e neonatais adversos

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein-coupled receptor lysosomal sorting.

The sorting of G protein-coupled receptors (GPCRs) to lysosomes is critical for proper signaling and cellular responses. We previously showed that the adaptor protein ALIX regulates lysosomal degradation of protease-activated receptor-1 (PAR1), a GPCR for thrombin, independent of ubiquitin-binding ESCRTs and receptor ubiquitination. However, the mechanisms that regulate ALIX function during PAR1 lysosomal sorting are not known. Here we show that the mammalian α-arrestin arrestin domain-containing protein-3 (ARRDC3) regulates ALIX function in GPCR sorting via ubiquitination. ARRDC3 colocalizes with ALIX and is required for PAR1 sorting at late endosomes and degradation. Depletion of ARRDC3 by small interfering RNA disrupts ALIX interaction with activated PAR1 and the CHMP4B ESCRT-III subunit, suggesting that ARRDC3 regulates ALIX activity. We found that ARRDC3 is required for ALIX ubiquitination induced by activation of PAR1. A screen of nine mammalian NEDD4-family E3 ubiquitin ligases revealed a critical role for WWP2. WWP2 interacts with ARRDC3 and not ALIX. Depletion of WWP2 inhibited ALIX ubiquitination and blocked ALIX interaction with activated PAR1 and CHMP4B. These findings demonstrate a new role for the α-arrestin ARRDC3 and the E3 ubiquitin ligase WWP2 in regulation of ALIX ubiquitination and lysosomal sorting of GPCRs

Rancang Bangun Collaborative System Pemasaran Hotel Secara On-line Dengan Pendekatan Mediator Based

One important aspect of the development of information and communication technology in the economic field is marketing through the Internet. The development of marketing through the Internet network since the last decade very rapidly. Transactions that occur very tempting. That\u27s why up a snowball effect, thus attracting businesses to leverage the Internet as a new marketing channels. This research was conducted to develop a marketing medium collaborative hotels. The approach used mediatore based. The methodology used in this collaborative media development is waterfall with steps Analysis, design, coding and testing. The results of this research is a collaborative media hotel marketing on-line has been implemented according to specifications that have been formulated in the SRS

The psychological determinants of internet gaming disorder: vulnerability to stress, psychological well-being, and comorbidity

INTRODUCTION: A variety of psychological determinants, such as vulnerability to stress, low levels of psychological well-being and several comorbidities, have been hypothesized to play a role in the development, and maintenance of Internet Gaming Disorder (IGD). However, evidence has been insufficient to sustain an overarching model of the causal pathways leading to IGD. OBJECTIVES: . This study aimed to depict a model of the causal links between vulnerability to stress, psychological well-being, and symptoms of common mental disorders (e.g., depression, generalized anxiety, phobic anxiety, obsessive-compulsive disorder, somatization, and hostility). METHODS: . A community-based sample of Portuguese gamers (N = 153; Mage = 21.92; 15.29% female) completed measures of IGD (IGDS9-SF), mental health (SCL-90-R), psychological well-being (EBEP), and vulnerability to stress (23QVS). A machine learning algorithm – Greedy Fast Causal Inference – was used to infer a model of the causal pathways linking those psychological determinants to IGD. RESULTS: . Hostility and psychological well-being were directly involved with a subgroup of IGD symptoms (i.e., gaming used as escape, tolerance, withdrawal, and loss of control). Stress vulnerability and symptoms of mental disorders were only indirectly implicated in the causal pathways leading to IGD. CONCLUSIONS: . It is likely that several psychological factors implicated in the causal pathways leading to IGD, have not been yet identified. Future research should directly test specific models of the causal pathways involved in the development and maintenance of IGD symptoms. DISCLOSURE: No significant relationships

Meningkatkan Kemampuan Literasi Matematis Mahasiswa melalui Bahan Ajar Berbasis Keterampilan Metakognisi

Kemampuan literasi matematis adalah kemampuan menerapkan konsep matematika dalam berbagai konteks, melakukan penalaran secara matematis dan menggunakan konsep, prosedur, serta fakta untuk menggambarkan, atau menjelaskan suatu kejadian. Seseorang jika mampu bernalar dan menganalisis melalui pengetahuan dan keterampilan matematikanya dalam penyelesaian masalah matematika maka ia memiliki kemampaun literasi yang baik. Diperlukan bahan ajar yang tepat untuk melibatkan kemampuan literasi seseorang. Bahan ajar yang melibatkan keterampilan metakognisi agar melibatkan kesadaran dalam memikirkan tentang proses berpikir. Tujuan penelitian adalah (1) mendeskripsikan kemampuan literasi; (2) mendeskripsikan bahan ajar yang melibatkat keterampilan metakognisi; (3) mendeskripsikan peningkatan kemampuan literasi matematis mahasiswa melalui bahan ajar berbasis keterampilan metakognisi. Subjek penelitian adalah mahasiswa STKIP Persada Khatulistiwa pada Prodi PGSD semester IV kelas B8 yang berjumlah 26 orang. Pengumpulan data dilakukan dengan metode tes dan observasi. Analisis data dilakukan dengan uji gain dan uji korelasi. Diperoleh kesimpulan bahwa (1) terdapat peningkatan kemampuan literasi matematis mahasiswa setelah diterapkannya pembelajaran dengan bahan ajar berbasis keterampilan metakognisi; (2) diperoleh kontribusi yang sedang antara bahan ajar berbasis keterampilan metakognisi dalam peningkatan kemampuan literasi matematis mahasiswa

Analisis Faktor-faktor yang Mempengaruhi Rendahnya Prestasi Belajar Siswa pada Mata Pelajaran Matematika di SD Negeri 04 Bati Tahun Pelajaran 2016/2017

Tujuan penelitian ini adalah untuk mengetahui prestasi belajar siswa dan faktor-faktor yang mempengaruhi rendahnya prestasi belajar siswa pada mata pelajaran matematika di Sekolah Dasar Negeri 04 Bati. Penelitian ini merupakan penelitian Survei dengan metode menggunakan pendekatan kuantitatif dengan analisis data menggunakan analisis faktor eksploratori dan analisis deskriptif. Jumlah populasi 115 orang siswa yang terdiri dari 60 orang laki-laki dan 55 orang perempuan. Sampel dalam penelitian ini adalah sebanyak 74 orang siswa. Pengumpulan data dilakukan dengan pedoman observasi, angket, wawancara dan dokumentasi. Hasil penelitian yaitu prestasi belajar siswa pada mata pelajaran matematika di Sekolah Dasar Negeri 04 Bati Tahun Pelajaran 2016/2017 kategori rendah, serta ditemukannya 7 (tujuh) faktor yang mempengaruhi rendahnya prestasi belajar siswa yaitu: (1) faktor fasilitas sekolah, (2) keluarga, (3) psikologis siswa, (4) kemampuan siswa, (5) interaksi siswa, (6) media elektronik, (7) kedisplinan siswa. Faktor yang memberi kontribusi paling besar adalah faktor fasilitas sekolah yaitu sebesar 20,759%, kontribusi terkecil diberikan oleh faktor kedisplinan siswa yaitu sebesar 4,719% dari keseluruhan kontribusi yang diberikan oleh seluruh faktor yang besarnya 68,6%

Pengaruh Angka Melek Huruf dan Angka Harapan Hidup terhadap Jumlah Penduduk Miskin di Propinsi Sumatera Barat

Poverty is a condition in which a person or family is unable to meet basic needs such as food, clothing, housing, education, and health. This study aimed to examine the effect of: (1) educational views of the literacy rate of the number of poor people, (2) health as seen from the amount of the life expectancy of the poor population and (3) the number of literacy rate and the number of digits life expectancy simultaneously to the number of poor people in the provinces of West Sumatra.The type of study is a quantitative and associative research, this study conducted in West Sumatra province. The data used in this study is a secondary data, the type of annual time series data from 2005 to 2011 were obtained from the BPS (Central Bureau of Statistics). The research variables are the number of poor is seen from the number of literacy rate and life expectancy the number of West Sumatra. The analysis model used is multiple linear regression analysis.Results of this study indicate that (1) literacy rate and a significant negative effect on the number of poor people in the provinces of West Sumatra, (sig = 0.004 <0.05) with the level of influence of -2.909 percent. (2) the life expectancy significantly and negatively related to the number of poor people in the provinces of West Sumatra, (Sig = 0.000 <0.05) with the level of influence of -4.353 percent (3) literacy rate and life expectancy significantly positive effect on the number of poor people in the provinces of West Sumatra together (sig = 0.000 <α = 0,05). Contribution together of independent variables to the dependent variable was used by 33.70 percent